HGG-25. Targeting the Epigenetic Modifier Hmga2 in Dipg and High Grade Gliomas Inhibits Proliferation, Invasion and Tumorigenicity

Kaur, Harpreet; Guo, Huizi; Akhtarkhavari, Sepehr; Eberhart, Charles G.; Raabe, Eric H.

doi:10.1093/neuonc/noz036.119

Cited by 2 publications

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“…These cells are assumed to persist in tumor tissues as a distinct population that may trigger relapse. HMGA2 has been shown to be involved in cancer stemness in different types of cancers [ 126 , 127 , 128 , 129 ]. Our recent study demonstrated that HMGA2 and CD133 positively correlate in breast tumors.…”

Section: Hmga2 Induce Cancer Proliferationmentioning

confidence: 99%

“…HMGA2 directly binds to the SOX2 promotor and regulates the expression of this gene, which encodes an important cancer stem cell marker [ 132 ]. In addition, another study demonstrated the positive regulatory role of HMGA2 on the SOX2 function in anaplastic astrocytoma side population cells [ 129 ]. A recent study indicated that the lin-28B-let-7-HMGA2 signaling axis controls the high self-renewal potential of fetal hematopoietic stem cells [ 18 ].…”

Section: Hmga2 Induce Cancer Proliferationmentioning

confidence: 99%

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HMGA2 as a Critical Regulator in Cancer Development

Mansoori

Mohammadi

Ditzel

et al. 2021

Genes

119

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The high mobility group protein 2 (HMGA2) regulates gene expression by binding to AT-rich regions of DNA. Akin to other DNA architectural proteins, HMGA2 is highly expressed in embryonic stem cells during embryogenesis, while its expression is more limited at later stages of development and in adulthood. Importantly, HMGA2 is re-expressed in nearly all human malignancies, where it promotes tumorigenesis by multiple mechanisms. HMGA2 increases cancer cell proliferation by promoting cell cycle entry and inhibition of apoptosis. In addition, HMGA2 influences different DNA repair mechanisms and promotes epithelial-to-mesenchymal transition by activating signaling via the MAPK/ERK, TGFβ/Smad, PI3K/AKT/mTOR, NFkB, and STAT3 pathways. Moreover, HMGA2 supports a cancer stem cell phenotype and renders cancer cells resistant to chemotherapeutic agents. In this review, we discuss these oncogenic roles of HMGA2 in different types of cancers and propose that HMGA2 may be used for cancer diagnostic, prognostic, and therapeutic purposes.

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