Hh‐Gli signaling pathway activity in oral and oropharyngeal squamous cell carcinoma

Abstract

The signaling pathway is activated in SCC and inducible in vitro by Shh protein.

The Hedgehog signaling pathway in ovarian teratoma is stimulated by Sonic Hedgehog which induces internalization of Patched

“…For negative control, slides were treated in the same way omitting the primary antibody step. For positive control, parallel staining was performed on squamous cell carcinoma slides which were positive for Ptch, Smo, Gli1 and Shh in our previous study (25).…”

LOH of PTCH1 region in BCC and ovarian carcinoma microsatellite vs HRM analysis

“…CGTTACCAGCCGAGGCCATGTT '3 (33). Samples that were uninformative were further typed for three additional STR markers (D9S196, D9S287 and D9S180) (17).…”

Molecular genetics of head and neck cancer (Review)

“…However, EGFR expression rates are lower in laryngeal tumors versus squamous cell carcinoma of the oral cavity or oropharynx (2). Several autocrine ligands, including TGFα and amphiregulin, activate the EGFR receptor, forming a dimer, which causes ATP-dependent autophosphorylation of the intracellular tyrosine residues (23). Upon phosphorylation, EGFR can trigger several downstream pathways, including PI3-K/Akt, sending anti-apoptotic signals, and MAPK/ERK, regulating cell proliferation, tumor induced neovascularization, invasion and metastasis (2).…”

“…The Hh signaling pathway is composed of 2 receptor complexes, patched (Ptch) and smoothened (Smo) (23). Once the Hh protein binds to the Ptch receptor, the normal inhibition on Smo is released, thus activating the pathway (24).…”

“…Hedgehog (Hh), a secreted protein, is involved in a number of embryonic developmental processes and maintaining stem and progenitor cells (23). The Hh signaling pathway is composed of 2 receptor complexes, patched (Ptch) and smoothened (Smo) (23).…”