HHV-6 in AIDS

Griffiths, Paul; Emery, Vincent C.; Lee, C.; Johnson, Margaret; McLaughlin, James E.

doi:10.1016/s0140-6736(94)90218-6

Cited by 8 publications

(2 citation statements)

References 4 publications

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“…However, if HHV-6 interstitial pneumonitis is an immunopathological condition, as has been proposed for HCMV (Grundy et al, 1987), it would require a functional immune system, which is defective in AIDS patients with low CD4 cell counts. This has to be taken into consideration when analysing the relationship of HHV-6 viral load and pneumonitis in such a patient group (Griffiths et al, 1994). Although we found higher HHV-6 loads in the lungs of AIDS patients compared to controls, no cases of interstitial pneumonitis occurred.…”

Section: ! Iiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiii IIImentioning

confidence: 68%

Quantification of Human Herpesvirus 6 in Immunocompetent Persons and Post-mortem Tissues from AIDS Patients by PCR

Clark

Ait‐Khaled

Wheeler

et al. 1996

Journal of General Virology

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Section: ! Iiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiii IIImentioning

confidence: 68%

Quantification of Human Herpesvirus 6 in Immunocompetent Persons and Post-mortem Tissues from AIDS Patients by PCR

Clark

Ait‐Khaled

Wheeler

et al. 1996

Journal of General Virology

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“…For HCMV, it has been proposed that interstitial pneumonitis may be due to direct effects of viral replication in the lungs, to immunopathologic effects initiated in response to HCMV infection, or to a combination of these mechanisms (reviewed in reference 65). According to Griffiths et al (205), HHV-6 is not necessarily an etiologic agent of pneumonitis (or of bone marrow suppression) in immunodeficient patients. They noted that Koch's postulates have not been fulfilled and suggested that the HHV-6 load in the lungs has not been shown to correlate with pneumonitis.…”

Section: Disease In Immunocompromised Hostsmentioning

confidence: 99%

Human herpesvirus 6.

Braun

Dominguez

Pellett

1997

Clinical Microbiology Reviews

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“Cytomegalovirus disease” in renal allograft recipients: Is human herpesvirus 7 a co-factor for disease progression?

et al. 1996

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Fifty-six renal allograft recipients were studied prospectively for 3 months or longer after transplant. The polymerase chain reaction (PCR) was used to screen peripheral blood leucocyte (PBL) specimens for CMV, human herpesvirus 6 (HHV6) and human herpesvirus 7 (HHV7) DNA (DNAemia) in 67 healthy controls and in serial (fortnightly) PBL specimens from the 56 allograft recipients. None of the healthy controls had detectable CMV DNAemia, although HHV6 and HHV7 DNAemia was found in 7% and 9% of individuals respectively. In contrast, DNAemia due to CMV, HHV6 and HHV7 was found in 50%, 36% and 39% of patients respectively, at some time during the post-transplant period. Of the 28 patients who had CMV DNAemia, eight developed "CMV disease". The risk of progression to "CMV disease" was increased in patients with concurrent DNAemia to all three viruses (relative risk 3.7; 95% CI 1.3-10.5). The relative risk of "CMV disease" for patients with concurrent CMV and HHV7 was also increased (RR = 3.5; 95% CI = 1.1-11.6), while the association between CMV and HHV6 was inconclusive (RR = v2.1; 95% CI = 0.7-6.6). The first 26 patients recruited to the study also had serial serum samples tested for antibody responses to the three viruses. "CMV disease" was associated with rising antibody titres to HHV7 (Fisher's exact test, P = 0.02), and weakly so with HHV6 (P = 0.07). It is concluded that in patients with CMV DNAemia, concurrent infection/reactivation HHV7 (and possibly HHV6) is associated with an increased risk of progression to "CMV disease".

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HHV-6 in AIDS

Cited by 8 publications

References 4 publications

Quantification of Human Herpesvirus 6 in Immunocompetent Persons and Post-mortem Tissues from AIDS Patients by PCR

Quantification of Human Herpesvirus 6 in Immunocompetent Persons and Post-mortem Tissues from AIDS Patients by PCR

Human herpesvirus 6.

“Cytomegalovirus disease” in renal allograft recipients: Is human herpesvirus 7 a co-factor for disease progression?

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