HHV8-positive, EBV-positive Hodgkin lymphoma-like large B-cell lymphoma and HHV8-positive intravascular large B-cell lymphoma

Ferry, Judith A.; Sohani, Aliyah R.; Longtine, Janina A.; Schwartz, Robert A.; Harris, Nancy L.

doi:10.1038/modpathol.2009.36

Cited by 61 publications

(49 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We demonstrated in our case the presence of KSHV/HHV-8 and EBV infection, as reported in other cases [1,4,5,9,13]. Apart from the association of KSHV/HHV-8 with KS, this virus also associates with 3 distinct lymphoproliferative diseases, mainly in HIV infection/AIDS patients: primary effusion lymphoma [2], multi-centric Castleman’s disease [14], and multicentric Castleman’s disease – associated plasmablastic lymphoma [6].…”

Section: Discussionsupporting

confidence: 90%

“…KSHV/HHV-8 was also identified in HIV-negative patients with a rare entity known as germinotropic lymphoproliferative disorder [3], and in extracavitary solid disuse large cell lymphomas with PEL-like morphology [5,15]. Subsequently, B-lineage lymphomas with a post-germinal-center immunophenotype were also described in association with KSHV/HHV-8 [4]. …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Simultaneous presentation of Kaposi sarcoma and HHV8-associated large B-cell lymphoma in the same lymph node: A rare diagnosis in an HIV-negative patient

et al. 2013

View full text Add to dashboard Cite

Patient: Female, 18Final Diagnosis: Simultanous presentation of Kaposi Sarcoma and LymphomaSymptoms: —Medication: —Clinical Procedure: —Specialty: OncologyObjectiveRare diseaseBackground:KSHV/HHV-8 is associated with Kaposi’s sarcoma (KS) as well as with a few categories of lymphoproliferative diseases, mostly occurring in patients with HIV infection/AIDS. Although the association between lymphomas and Kaposi’s sarcoma has been described, the simultaneous presence of the 2 entities within the same organ is rare and mainly associated with HIV/ AIDS.Case Report:We report a case of simultaneous occurrence of Kaposi‘s sarcoma and large B-cell lymphoma in the same lymph node in a 18-year-old African woman who was HIV-negative. We found concurrent infection with Kaposi’s sarcoma herpes virus (KSHV) and Epstein-Barr virus (EBV), confirmed by PCR amplification of DNA obtained from distinct tumor areas selected in the paraffin block.Conclusions:The possibility of occurrence of 2 lesions with distinct features in the same organ may be unexpected for pathologists performing fine-needle aspiration cytology (FNAC) evaluation but must be considered, even in HIV-negative individuals, despite its rare occurrence, as was demonstrated by this case.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Simultaneous presentation of Kaposi sarcoma and HHV8-associated large B-cell lymphoma in the same lymph node: A rare diagnosis in an HIV-negative patient

et al. 2013

View full text Add to dashboard Cite

show abstract

“…They were completely devoid of lineage specific antigens; however, they demonstrated immunostaining with plasma cell reactive antibodies [13]. Also, cases of HHV8-positive large B-cell lymphoma with varying histological features including appearance suggestive of classical Hodgkin’s lymphoma in an immunocompetent patient and showing features of intravascular large B-cell lymphoma in an HIV-positive patient have been reported, expanding the spectrum of lymphoproliferative disorders that can be associated with HHV8 [14]. …”

Section: Discussionmentioning

confidence: 99%

KSHV-associated and EBV-associated Germinotropic Lymphoproliferative Disorder

Bhavsar

Lee

Perner

et al. 2017

American Journal of Surgical Pathology

View full text Add to dashboard Cite

We report two cases of Kaposi sarcoma associated herpesvirus (KSHV) - and Epstein Barr Virus (EBV)-associated germinotropic lymphoproliferative disorder (GLPD). Both cases arose in patients from regions endemic for KSHV, Cape Verde and the Democratic Republic of the Congo, presenting as localized lymphadenopathy. The affected lymph nodes showed colonization of the follicles by clusters of large atypical plasmablasts, but also showed regressive changes with vascular proliferation and interfollicular plasmacytosis, both reminiscent of HHV8-positive multicentric Castleman disease (MCD). The atypical plasmablasts showed dual positivity for HHV-8 and EBV, being positive for LANA and viral IL-6, as well as EBER by in-situ hybridization. They showed a Latency I phenotype, being negative for LMP1, EBNA2 and BZLF-1. The plasmablasts were negative for immunoglobulin light chains, and in one case with successful DNA amplification had a polyclonal immunoglobulin rearrangement pattern. GLPD is a rare disorder, with only 6 cases reported in the literature. We demonstrate for the first time the expression of HHV-8 viral IL-6 and provide evidence for Latency I phenotype for EBV. Additionally, one case progressed to an EBV-positive diffuse large B-cell lymphoma, but interestingly was negative for KSHV/HHV-8, likely indicative of tumor derived from an independent clone.

show abstract

“…20 Prevalence of somatic mutations varies widely between cases of IVLBCL, with one study demonstrating complementarity determining region 2 and framework region 3 to have 74.7% to 99.4% homology to their closest germline genes. 20 Although isolated cases of viral infections of IVLBCL cells have been reported (ie, Epstein-Barr virus [EBV] and human herpesvirus 8), 21,22 to our knowledge, a causal relationship between infectious agents and IVLBCL has not yet been demonstrated. Active infections by EBV, cytomegalovirus, herpes simplex virus types 1 and 2, vesicular stomatitis virus, human herpesvirus 6, and human T-cell lymphotropic virus type 1 have been effectively ruled out as a mandatory prerequisite for disease development.…”

Section: Cytogenetics and Molecular Geneticsmentioning

confidence: 99%

Intravascular Large B-Cell Lymphoma

Orwat

Batalis²

2012

Archives of Pathology &Amp; Laboratory Medicine

108

View full text Add to dashboard Cite

A rare type of diffuse large B-cell lymphoma, intravascular large B-cell lymphoma primarily affects the middle-aged to elderly population, with a slight predominance in men. By the time of presentation, most patients have advanced, disseminated disease, and often the diagnosis is made at autopsy. Patients may present with any of a myriad of symptoms, with any tissue potentially being infiltrated. Central nervous system and cutaneous involvement is common, as is the presence of B symptoms including fever, weight loss, and night sweats. Morphologically, growth of neoplastic cells is restricted to the lumen of small vessels. The cells are large, with 1 or more prominent nucleoli, scant cytoplasm, and frequent mitotic figures, and are commonly positive for cluster of differentiation markers 79a, 20, and 19, as well as MUM1/IRF4 and Bcl-2. Intravascular large B-cell lymphoma is aggressive, and without treatment is rapidly fatal.

show abstract

HHV8-positive, EBV-positive Hodgkin lymphoma-like large B-cell lymphoma and HHV8-positive intravascular large B-cell lymphoma

Cited by 61 publications

References 28 publications

Simultaneous presentation of Kaposi sarcoma and HHV8-associated large B-cell lymphoma in the same lymph node: A rare diagnosis in an HIV-negative patient

Simultaneous presentation of Kaposi sarcoma and HHV8-associated large B-cell lymphoma in the same lymph node: A rare diagnosis in an HIV-negative patient

KSHV-associated and EBV-associated Germinotropic Lymphoproliferative Disorder

Intravascular Large B-Cell Lymphoma

Contact Info

Product

Resources

About