1994
DOI: 10.1016/0264-410x(94)90039-6
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HI antibody kinetics in adult volunteers immunized repeatedly with inactivated trivalent influenza vaccine in 1990–1992

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1995
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Cited by 48 publications
(16 citation statements)
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“…GMT and fold increase were also similar among groups and were higher for the pandemic H1N1 vaccine strain than for the other vaccine strains, consistent with the higher changes in antibody titers with first-time exposure than with repeated exposure to the same influenza antigen [36,37]. No differences were found when we compared heroin and methadone users to controls.…”
Section: Discussionsupporting
confidence: 70%
“…GMT and fold increase were also similar among groups and were higher for the pandemic H1N1 vaccine strain than for the other vaccine strains, consistent with the higher changes in antibody titers with first-time exposure than with repeated exposure to the same influenza antigen [36,37]. No differences were found when we compared heroin and methadone users to controls.…”
Section: Discussionsupporting
confidence: 70%
“…All hemophiliac children involved in the present study had previously been vaccinated against influenza in the epidemic season 1993–94, so immunization in autumn 1996–97 was their second vaccination. In spite of this fact, the humoral immune response to influenza vaccine observed in these patients did not weaken, as many authors suggest [26–29]. This is clearly seen when the results of this study are compared with data obtained in our previous investigation on seroconversion in once‐immunized hemophiliac children [30].…”
Section: Discussionsupporting
confidence: 63%
“…This increase in the initial anti-vaccine titer, however, has been shown to reduce the overall vaccine-induced B cell response and correlate with the generation of plasmablast and memory B cells [36]. This suppressive effect of pre-vaccination antibodies to vaccination-induced antibody response can be explained, at least in part, by immune complex formation [37] and reduction of the effective antigen concentration to stimulate B/T cells. Alternatively, higher levels of pre-vaccination antibodies might have blocked the general activation of B cells upon vaccination [22], or they might have masked viral epitopes in the vaccine, preventing binding and activation of memory B cells recognizing that particular epitope [36].…”
Section: Discussionmentioning
confidence: 99%