Hibernoma-like brown fat in the bone marrow: report of a unique case

Thorns, Christoph; Schardt, Christof; Katenkamp, D.; Kähler, C.; Merz, Hartmut; Feller, Alfred C.

doi:10.1007/s00428-007-0559-4

Cited by 29 publications

(22 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The existence of BAT in bone marrow (BM), which attenuates with aging and diabetes, was reported in mice (Krings et al, 2012). Also, a nontumorous infiltration of BAT in human BM was reported in a case of essential hyperthrombocythemia (Thorns et al, 2008). A functional link between BM fat and hematopoiesis was first reported by Dexter et al (Dexter et al, 1977), who showed that BM adipocytes with mitochondria-attached multilocular lipid droplets were essential for the maintenance of colony-forming units-spleen (CFU-S), a short-term repopulating hematopoietic progenitor cell (HPC) distinct from hematopoietic stem cell (HSC).…”

Section: Introductionmentioning

confidence: 99%

Production of Functional Classical Brown Adipocytes from Human Pluripotent Stem Cells using Specific Hemopoietin Cocktail without Gene Transfer

et al. 2012

View full text Add to dashboard Cite

Brown adipose tissue is attracting much attention due to its antiobestic effects; however, its development and involvement in metabolic improvement remain elusive. Here we established a method for a high-efficiency (>90%) differentiation of human pluripotent stem cells (hPSCs) into functional classical brown adipocytes (BAs) using specific hemopoietin cocktail (HC) without exogenous gene transfer. BAs were not generated without HC, and lack of a component of HC induced white adipocyte (WA) marker expressions. hPSC-derived BA (hPSCdBA) showed respiratory and thermogenic activation by β-adrenergic receptor (AdrRβ) stimuli and augmented lipid and glucose tolerance, whereas human multipotent stromal cell-derived WA (hMSCdWA) improved lipid but inhibited glucose metabolism. Cotransplantation of hPSCdBA normalized hMSCdWA-induced glucose intolerance. Surprisingly, hPSCdBAs expressed various hemopoietin genes, serving as stroma for myeloid progenitors. Moreover, AdrRβ stimuli enhanced recovery from chemotherapy-induced myelosuppression. Our study enhances our understanding of BA, identifying roles in metabolic and hemogenic regulation.

show abstract

Section: Introductionmentioning

confidence: 99%

Production of Functional Classical Brown Adipocytes from Human Pluripotent Stem Cells using Specific Hemopoietin Cocktail without Gene Transfer

et al. 2012

View full text Add to dashboard Cite

show abstract

“…35 This idea is also supported by the fact that so-called hibernomas, rare and benign tumors consisting of brown adipocytes, can develop in bone marrow. 36,37 Recently, it was shown that MAT has a distinct phenotype resembling both WAT and BAT. 38 The authors showed that MAT expresses several BAT-selective genes including Prdm16, Dio2 and Pgc1α at similar levels as in the interscapular BAT depot.…”

Section: Bat and Thermogenic Adipocytesmentioning

confidence: 99%

Brown adipose tissue and bone

Lidell

Enerbäck

2015

Int J Obes Supp

View full text Add to dashboard Cite

ME Lidell and S EnerbäckBrown adipose tissue (BAT) is capable of transforming chemically stored energy, in the form of triglycerides, into heat. Recent studies have shown that metabolically active BAT is present in a large proportion of adult humans, where its activity correlates with a favorable metabolic status. Hence, the tissue is now regarded as an interesting target for therapies against obesity and associated diseases such as type 2 diabetes, the hypothesis being that an induction of BAT would be beneficial for these disease states. Apart from the association between BAT activity and a healthier metabolic status, later studies have also shown a positive correlation between BAT volume and both bone cross-sectional area and bone mineral density, suggesting that BAT might stimulate bone anabolism. The aim of this review is to give the reader a brief overview of the BAT research field and to summarize and discuss recent findings regarding BAT being a potential player in bone metabolism.

show abstract

“…Nishio et al (2012) developed an alternative approach to reprogram hES and IPS cells into functional brown adipocytes both in vitro and in vivo with an efficiency of O90% without utilizing exogenous gene transfer. The protocol was initially discovered by observations that conditions which were established to differentiate cells of the haematopoietic lineage resulted in the production of significant numbers of brown adipocytes (Thorns et al 2008, Krings et al 2012. They employed a haemopoietic cocktail (HC) composed of KIT ligand (KITGL), fms-related tyrosine kinase 3 ligand (FLT3LG), interleukin 6 (IL6), and VEGF along with the previously reported BAT inducer BMP7 (Tseng et al 2008).…”

Section: Brown Adipocytes Differentiated From Hes and Ips Cellsmentioning

confidence: 99%

Adipogenesis: new insights into brown adipose tissue differentiation

Carobbio

Rosen

Vidal-Puig

2013

Journal of Molecular Endocrinology

View full text Add to dashboard Cite

Confirmation of the presence of functional brown adipose tissue (BAT) in humans has renewed interest in investigating the potential therapeutic use of this tissue. The finding that its activity positively correlates with decreased BMI, decreased fat content, and augmented energy expenditure suggests that increasing BAT mass/activity or browning of white adipose tissue (WAT) could be a strategy to prevent or treat obesity and its associated morbidities. The challenge now is to find a safe and efficient way to develop this idea. Whereas BAT has being widely studied in murine models both in vivo and in vitro, there is an urgent need for human cellular models to investigate BAT physiology and functionality from a molecular point of view. In this review, we focus on the latest insights surrounding BAT development and activation in rodents and humans. Then, we discuss how the availability of murine models has been essential to identify BAT progenitors and trace their lineage. Finally, we address how this information can be exploited to develop human cellular models for BAT differentiation/activation. In this context, human embryonic stem and induced pluripotent stem cells-based cellular models represent a resource of great potential value, as they can provide a virtually inexhaustible supply of starting material for functional genetic studies, -omics based analysis and validation of therapeutic approaches. Moreover, these cells can be readily genetically engineered, opening the possibility of generating patient-specific cellular models, allowing the investigation of the influence of different genetic backgrounds on BAT differentiation in pathological or in physiological states.

show abstract

Hibernoma-like brown fat in the bone marrow: report of a unique case

Cited by 29 publications

References 7 publications

Production of Functional Classical Brown Adipocytes from Human Pluripotent Stem Cells using Specific Hemopoietin Cocktail without Gene Transfer

Production of Functional Classical Brown Adipocytes from Human Pluripotent Stem Cells using Specific Hemopoietin Cocktail without Gene Transfer

Brown adipose tissue and bone

Adipogenesis: new insights into brown adipose tissue differentiation

Contact Info

Product

Resources

About