Hibiclens Keratitis

Hamed, Latif M.; Ellis, Forrest D.; Boudreault, Ghislain; Wilson, Fred M.; Helveston, Eugene M.

doi:10.1016/0002-9394(87)90292-3

Cited by 52 publications

(14 citation statements)

References 23 publications

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“…Such a layer has been found in the rabbit [2], We think this is the most likable explanation. Four of our five patients developed secundary glaucoma.…”

Section: Discussionsupporting

confidence: 55%

Toxic keratopathy due to the accidental use of chlorhexidine, cetrimide and cialit

et al. 1995

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Abstract. Due to economical reasons some ophthalmologists are using an irrigating solution made by the hospital pharmacy instead of the commercially available solutions. These irrigat ing solutions come in bottles which are identical to the ones used for other solutions. During the last three years bottles were accidentally mixed up five times. Consequently, bottles containing solutions such as Chlorhexidine, cetrimide, chlorhexidine/cetrimide and cialit solutions were used during cataract surgery. This resulted in immediate corneal edema which, in its turn result ed in a bullous keratopathy. Four patients underwent a penetrating keratoplasty. In one patient the cornea was covered with a conjunctival flap. Light microscopy of the corneas included epithelial edema, loss o f keratocytes, and a disrupted and sometimes absent endothelial cell layer.

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“…Such a layer has been found in the rabbit [2], We think this is the most likable explanation. Four of our five patients developed secundary glaucoma.…”

Section: Discussionsupporting

confidence: 55%

Toxic keratopathy due to the accidental use of chlorhexidine, cetrimide and cialit

et al. 1995

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“…8,64,65 Quinolones, such as norfloxacin and ciprofloxacin, should be avoided in pregnancy because of studies showing cartilaginous damage in infants born to animals who have received these drugs during pregnancy. [71][72][73][74][75] Hexachlorophene is generally not recommended in pregnant patients due to reports of teratogenic effects and central nervous system (CNS) toxicity in the fetus. 66 Hemolytic anemia has also been reported in a fetus born to a mother homozygous for glucose-6-phosphate dehydrogenase (G6PD) deficiency who was taking sulfisoxazole.…”

Section: Antibiotics and Antiseptics In The Pregnant Patientmentioning

confidence: 99%

Dermatologic Surgery and the Pregnant Patient

Richards

Stasko

2002

Dermatologic Surgery

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background. Because of concerns about potential harm to the mother or fetus, dermatologic surgeons are frequently hesitant to perform cutaneous surgery on pregnant patients. objective. To review the relevant physiologic changes during pregnancy, appropriate preparation for and timing of procedures, and drug safety. methods. A literature review was performed of dermatologic and nondermatologic journals discussing physiology, surgery, and drug safety in the pregnant patient. results. Special positioning is required for the pregnant patient during surgery. Low doses of most local anesthetics with epinephrine as well as nitrous oxide less than 50% are safe to use during pregnancy. Sedatives and opioids are potential teratogens and should be avoided. Safe antibiotics to use during skin surgery in pregnancy include penicillins, cephalosporins, and nonestolate erythromycin. If necessary, lymph node dissections under general anesthesia in the pregnant melanoma patient should occur during the second trimester. conclusion. With appropriate preparation, safe and successful cutaneous surgery can be performed on the pregnant patient. Respiratory ChangesBy term, there is an increase in tidal volume and minute respiration to 30-40% due to increased fetal K.A. Richards, MD and T. Stasko, MD have indicated no significant interest with commercial supporters.

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“…Hamed et al described similar findings in three experimental eyes of albino rabbits, which were exposed to Hibiclens. 4 All three experimental eyes showed nearly total denudation of the corneal epithelium and stromal edema. Histopathologic examination in the three eyes showed epithelial sloughing almost to Bow- man's membrane.…”

Section: Discussionmentioning

confidence: 98%

“…Hamed et al also described two cases of keratitis after accidental ocular exposure to Hibiclens during fascial skin preparation before surgery. 4 One patient was undergoing a cataract extraction. She was noted to have a large corneal epithelial defect on the first postoperative day.…”

Section: Discussionmentioning

confidence: 99%