Hibiscus sabdariffa L.: phytoconstituents, nutritive, and pharmacological applications

Salem, Mohamed A.; Zayed, Ahmed; Beshay, Magy E.; Mesih, Mirna M. Abdel; Khayal, Reem F. Ben; George, Fady A.; Ezzat, Shahira M.

doi:10.1007/s13596-020-00542-7

Cited by 19 publications

(21 citation statements)

References 99 publications

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“…Due to the high content of pharmacologically active compounds and thus good healing properties, roselle has been well known and widely used in traditional medicine for thousands of years [ 2 , 3 ]. In addition to its medical use, roselle is widely used in the culinary arts as a source of nutrients or as a natural dye that is used in the food and textile industries [ 4 , 5 , 6 ]. Today it is cultivated almost everywhere in the tropics and subtropics; in Mexico, India, Saudi Arabia, China, Vietnam, Sudan, Egypt, Malaysia, Indonesia, the Philippines, and Nigeria [ 7 ].…”

Section: Hibiscus Sabdariffa —Characteristicmentioning

confidence: 99%

“…Roselle is widely used as a source of nutrients and natural dyes in the food industry [ 4 , 5 ]. Many parts of roselle can be consumed, but the calyces are the most popular in culinary products [ 10 ].…”

Section: Hibiscus Sabdariffa —Characteristicmentioning

confidence: 99%

“…Fresh or dried, they are also used in the production of ice cream, jams, wine, chocolate, and fermented beverages or as an additive to improve the taste of other beverages. The calyces can also be pickled [ 4 , 5 , 10 , 11 , 12 ]. Aqueous preparations such as decoction or infusions are generally regarded as safe and can be consumed as hot or cold drinks.…”

Section: Hibiscus Sabdariffa —Characteristicmentioning

confidence: 99%

“…These low-calorie drinks possess little carbohydrates and are characterized by a high acid content, thus are sour in taste. To soothe this taste, many additives such as fruits or sweeteners may be mixed with roselle-containing drinks [ 5 , 10 ]. The reports regarding the nutritional value of the roselle calyces differ.…”

Section: Hibiscus Sabdariffa —Characteristicmentioning

confidence: 99%

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Hibiscus sabdariffa in Diabetes Prevention and Treatment—Does It Work? An Evidence-Based Review

Jamrozik

Borymska

Kaczmarczyk-Sedlak

2022

Foods

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Diabetes is currently a global health problem that is already reported as an epidemic. This metabolic disease, characterized by a disturbance in the carbohydrate, protein, and lipid metabolism, is often accompanied by disorders of several organs. Its treatment is expensive and often difficult to control. Therefore, it seems necessary to search for new drugs and solutions to facilitate therapy and reduce treatment costs. Herbal medicines are becoming more and more popular. Hibiscus sabdariffa (roselle) is a plant that grows wild in a tropical climate. It has been used in folk medicine for thousands of years. Thanks to the numerous active compounds, including polyphenols, polysaccharides, organic acids, or pectins, it is reported to exhibit hypoglycemic, antioxidant, hypotensive, and anti-lipidemic activities and numerous indirect effects that are related to them. The aim of this review was to update the knowledge about the therapeutic effects of roselle in diabetes and its comorbidities based on in vitro, animal, and human studies. After a careful analysis of the scientific literature, it can be stated that roselle is a promising product that can be used either on its own or as an addition to the conventional treatment regimens to prevent or treat diabetes and its accompanying diseases.

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Section: Hibiscus Sabdariffa —Characteristicmentioning

confidence: 99%

Section: Hibiscus Sabdariffa —Characteristicmentioning

confidence: 99%

Section: Hibiscus Sabdariffa —Characteristicmentioning

confidence: 99%

Section: Hibiscus Sabdariffa —Characteristicmentioning

confidence: 99%

See 2 more Smart Citations

Hibiscus sabdariffa in Diabetes Prevention and Treatment—Does It Work? An Evidence-Based Review

Jamrozik

Borymska

Kaczmarczyk-Sedlak

2022

Foods

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“…Hibiscus Sabdariffa has been used as food raw materials or medicinal healthcare ingredients in my countries (Riaz & Chopra, 2018). It is of great significance to develop Hibiscus Sabdariffa related products through multi-channel, and speed up the way of industrialization development to promote the usage of the active component of Hibiscus Sabdariffa and increase its economic values through deep processing (Salem et al, 2021). The calyx of Hibiscus Sabdariffa is purplish red, which contains a lot of organic acids such as citric acid, hibiscic acid, reducing sugar, vitamin C, protein, natural pigment and minerals (Zhen et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Research on complex enzyme system to extract Hibiscus Sabdariffa L reducing sugar

Liu¹,

Chen

2022

Food Sci. Technol

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Hibiscus Sabdariffa L. has important nutritional and medicinal value. Currently, a safe process extraction of reducing sugar from Hibiscus Sabdariffa L. calyx by biological complex enzyme system is seldom investigated. In this experiment, the pectinase and cellulase complex enzyme system was used to optimize the enzymatic hydrolysis of Hibiscus Sabdariffa L. and Box behnken was used to design the experiment. The results showed that there was significant difference in enzymolysis effect of Hibiscus Sabdariffa L under different conditions (p < 0.05). When the enzymolysis temperature was 45 °C, pH 4.5, and the mass volume ratio of material to liquid was 5g:100ml, the optimum conditions were obtained by response surface methodology: the addition amount of pectinase and cellulase complex enzyme was 0.011 g/kg, the ratio of mixed enzyme was 1.36:1, the enzymolysis time was 2.09 h, and the reducing sugar content of Hibiscus Sabdariffa L extract was 3.56 mg/ml. The experimental results of reducing sugar content of Hibiscus Sabdariffa L (3.54 ± 0.1mg / ml) were in good agreement with the predicted value of the equation fitted by response surface. The mixed enzyme system of pectinase and cellulase has the advantages of environmental protection and energy saving, which can provide guidance for industrial production.

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Hibiscus schizopetalus boosts wound healing via restoring redox balance and hindering inflammatory responses in rats: Insights on metabolome profiling and molecular docking

Gamal El‐Din,

Mantawy,

Said

et al. 2024

Archiv der Pharmazie

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Hibiscus species (Malvaceae) possess a plethora of appealing pharmacological activities with an extended history of customary use in diverse medical conditions. The present study aimed at comparing the metabolomic analyses of three Hibiscus species native to Egypt, namely H. tiliaceus, H. schizopetalus extract (HSE), and H. rosa‐sinensis, alongside identifying a promising natural wound healing candidate. Chemical profiling of the leaf extracts was achieved via UPLC‐ESI/MS/MS‐guided analysis that resulted in the tentative identification of a total of 48 secondary metabolites pertaining to phenolic acids, flavonoids, anthocyanins, fatty acids, and fatty amides. Remarkably, in vitro studies revealed that HSE exhibited the topmost wound healing activity. Subsequently, HSE was formulated into hydro‐ and nanogel (1% w/v) formulations for further assessing its efficacy in the wound excision model. HSE‐nanogel demonstrated a significant in vivo wound contraction activity alongside improving histopathological abnormalities. Mechanistically, HSE‐nanogel upregulated the wound antioxidant status through increasing the levels of reduced glutathione (GSH) and catalase activity. Moreover, HSE‐nanogel suppressed the wound inflammatory responses by diminishing the expressions of NF‐ĸB, TNF‐α, and IL‐6. Molecular docking studies were performed on HSE's major constituents using CDOCKER, which further supported the in vivo findings. Collectively, HSE nanogel exhibits notable aptitude as a wound‐healing agent, warranting further clinical appraisal.

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Hibiscus sabdariffa L.: phytoconstituents, nutritive, and pharmacological applications

Cited by 19 publications

References 99 publications

Hibiscus sabdariffa in Diabetes Prevention and Treatment—Does It Work? An Evidence-Based Review

Hibiscus sabdariffa in Diabetes Prevention and Treatment—Does It Work? An Evidence-Based Review

Research on complex enzyme system to extract Hibiscus Sabdariffa L reducing sugar

Hibiscus schizopetalus boosts wound healing via restoring redox balance and hindering inflammatory responses in rats: Insights on metabolome profiling and molecular docking

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