Hibiscus syriacus L. Extract by ultrasonic assistance displays anti-inflammatory and pro-apoptotic activity in LPS-stimulated Raw 264.7 cells

Lee, Chang Min; Kang, Mi Young; Lee, Jongbok; Park, Kyungmoon; Kim, Hee Taek; Yang, Yung‐Hun; Lee, Jongsung; Park, See‐Hyoung

doi:10.1016/j.arabjc.2023.105168

Cited by 2 publications

(2 citation statements)

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“…One such example of these medicinal plant foods includes vegetables such as Hibiscus syriacus . This plant has been the subject of research and is recognized for its anti-inflammatory properties [ 29 ] as well as its pro-apoptotic, antibacterial, and antioxidant characteristics, which notably enhance blood circulation [ 30 ]. Nevertheless, the potential of Hibiscus syriacus L. as an antidiabetic agent has not been extensively investigated.…”

Section: Discussionmentioning

confidence: 99%

“…This reduction may be attributed to the polyphenolic compounds found in H. syriacus , which are known to influence the activity of enzymes pivotal to lipoprotein metabolism. H. syriacus L. is rich in various components, such as fatty acids, naphthalene pentacyclic triterpene esters and 9,9-O-Ferulolyl-(--)-sequisolaricinresinol, gamma-tocopherol, sitosterol, and squalene, all of which are known to be powerful antioxidants and antifungal properties [ 29 ]. Considering these findings, we conclude that absolute HSE could possibly inhibit the overproduction of ROS in all tissues.…”

Section: Discussionmentioning

confidence: 99%

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A Holistic In Silico and In Vivo Approach to Exploring the Antidiabetic, Antioxidant, and Hepatoprotective Properties of Rose of Sharon

Ziyanok-Demirtas

2024

Life

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Diabetes mellitus (DM) is a significant global health burden that necessitates the exploration of effective and accessible therapeutic options. Phytotherapy has played a vital role in healthcare, with plant extracts being integral to traditional medicinal practices. The therapeutic potential of Hibiscus syriacus (Rose of Sharon), a plant with a rich ethnobotanical history, in the management of DM and its associated complications was investigated. In this study, the therapeutic potential of Hibiscus syriacus L. extract (HSE) against DM in streptozotocin (STZ)-induced diabetic rats was assessed, focusing on its effects on glucose regulation, antioxidative defense, and liver protection. The administration of the HSE extract substantially reduced hyperglycemia and increased insulin production, with concurrent improvements in body weight and hydration. The enhanced activity of antioxidant enzymes, such as superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), suggests reduced oxidative stress, which is further supported by molecular docking results with the 3GTV superoxide dismutase enzyme, showing a binding energy of −6.3 kcal/mol. A decrease in MDA levels also indicates a reduction in oxidative stress. Notably, HSE treatment led to decreased aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels and improved lipid profiles, indicating its hepatoprotective and lipid-modifying benefits. These findings support the inclusion of HSE as an adjunctive therapy in DM management strategies. This study promotes the consideration of Hibiscus syriacus L. therapeutic properties in global health contexts.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Holistic In Silico and In Vivo Approach to Exploring the Antidiabetic, Antioxidant, and Hepatoprotective Properties of Rose of Sharon

Ziyanok-Demirtas

2024

Life

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Flavonoid profiling of Plumula nelumbinis and evaluation of their anti‐inflammatory effects on lipopolysaccharide‐induced RAW 264.7 macrophages

Li,

Wu,

Liu

et al. 2024

eFood

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The lotus seed embryo, known as “Plumula nelumbinis,” holds significance in Chinese culture as a traditional medicinal and edible herb rich in beneficial bioactive compounds like flavonoids, alkaloids, and polyphenols. Using ultrahigh‐performance liquid chromatography‐quadrupole‐exactive Orbitrap mass spectrometry, we meticulously analyzed the total flavonoids in Plumula nelumbinis (PNF) sourced from Hangzhou's West Lake. Our investigation preliminarily identified 29 flavonoid compounds, including 21 flavonoid O‐glycosides, five flavonoid C‐glycosides, and three aglycones, through comparisons with standards and literature references. Subsequent cellular anti‐inflammatory experiments using lipopolysaccharide (LPS)‐induced RAW264.7 cells demonstrated that treatment with 300 μg/mL of lotus seed flavonoids significantly reduced inflammatory factors' production, such as nitric oxide, prostaglandin E2, tumor necrosis factor, interleukin‐6, and interleukin‐1β. Additionally, PNF effectively lowered intracellular reactive oxygen species levels, mitigated LPS‐induced cell apoptosis, and nuclear translocation of nuclear factor‐κB (NF‐κB) p65 protein, collectively suppressing the NF‐κB p65 inflammatory pathway and demonstrating potent anti‐inflammatory properties. Crucially, the observed gene expression patterns of inflammatory factors aligned with their respective protein secretion levels. This study provides a comprehensive exploration of lotus seed flavonoids' anti‐inflammatory potential, highlighting their significance in potential therapeutic applications and laying the groundwork for future advancements in related functional foods.

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Hibiscus syriacus L. Extract by ultrasonic assistance displays anti-inflammatory and pro-apoptotic activity in LPS-stimulated Raw 264.7 cells

Cited by 2 publications

References 42 publications

A Holistic In Silico and In Vivo Approach to Exploring the Antidiabetic, Antioxidant, and Hepatoprotective Properties of Rose of Sharon

A Holistic In Silico and In Vivo Approach to Exploring the Antidiabetic, Antioxidant, and Hepatoprotective Properties of Rose of Sharon

Flavonoid profiling of Plumula nelumbinis and evaluation of their anti‐inflammatory effects on lipopolysaccharide‐induced RAW 264.7 macrophages

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