2024
DOI: 10.1101/2024.01.03.574110
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Hidden route of protein damage through confined oxygen gas

Seoyoon Kim,
Eojin Kim,
Mingyu Park
et al.

Abstract: Oxidative modifications can severely impair protein structure, fold, and function, closely linked to human aging and diseases. Conventional oxidation pathways typically involve the free diffusion of reactive oxygen species (ROS), followed by chemical attacks on the protein surface. Here, we report a hidden route of protein oxidative damage, which we refer to as O2-confinement oxidation pathway. This pathway starts with the initial trapping of dissolved molecular oxygen (O2) within protein cavity spaces, follow… Show more

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