Hidradenitis suppurativa: a disease of the absent sebaceous gland? Sebaceous gland number and volume are significantly reduced in uninvolved hair follicles from patients with hidradenitis suppurativa

Kamp, Søren; Fiehn, Anne-Marie Kanstrup; Stenderup, Karin; Rosada, Cecilia; Pakkenberg, Bente; Kemp, K.; Dam, Tomas Norman; Jemec, Gregor B. E.

doi:10.1111/j.1365-2133.2011.10224.x

Cited by 123 publications

(101 citation statements)

References 37 publications

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“…Similar changes in SGs were also found in patients with hidradenitis suppurativa/acne inversa, in whom cigarette smoking is a high risk factor [140]. In addition, ex vivo studies also reported that dioxins and benzo(a)pyrene (BaP), representative toxicants found in environmental pollutants and cigarette smoke, strongly inhibited lipogenesis in human SZ95 sebocytes and reduced the size of SGs via activation of the aryl hydrocarbon receptor (AhR) signaling pathway [141,142].…”

Section: Sebaceous Glands and Skin Skin Detoxificationsupporting

confidence: 51%

Beyond acne: Current aspects of sebaceous gland biology and function

Zouboulis¹,

Picardo

Qiang

et al. 2016

Rev Endocr Metab Disord

118

112

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The sebaceous gland is mostly found in association with a hair follicle. Its traditional function is the holocrine production of sebum, a complex mixture of lipids, cell debris, and other rather poorly characterized substances. Due to the gland central role in acne pathogenesis, early research had focused on its lipogenic activity. Less-studied aspects of the sebaceous gland, such as stem cell biology, the regulation of cellular differentiation by transcription factors, the significance of specific lipid fractions, the endocrine and specially the neuroendocrine role of the sebaceous gland, and its contribution to the innate immunity, the detoxification of the skin and skin aging have recently attracted the attention of researchers from different disciplines. Here, we summarize recent, multidisciplinary progress in sebaceous gland research and discuss how sebaceous gland research may stimulate the development of novel therapeutic strategies targeting specific molecular pathways of the pathogenesis of skin diseases.

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Section: Sebaceous Glands and Skin Skin Detoxificationsupporting

confidence: 51%

Beyond acne: Current aspects of sebaceous gland biology and function

Zouboulis¹,

Picardo

Qiang

et al. 2016

Rev Endocr Metab Disord

118

112

View full text Add to dashboard Cite

show abstract

“…(2). Histopathology studies imply that keratin plugging of follicles is an early feature of HS, together with a lymphocytic infiltrate and an atrophy of sebaceous glands (3,4).…”

Section: Accepted For Publication 22 December 2015mentioning

confidence: 99%

Mechanical stress and the development of pseudo‐comedones and tunnels in Hidradenitis suppurativa/Acne inversa

Boer

Jemec

2016

Experimental Dermatology

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“…Furthermore, studies have shown that similar to acne toll-like receptor 2 expression is increased in macrophages and dendritic cells of patients with HS [9]. However, there are several differences which exist between acne and HS including microbiology, clinical presentation, and response to treatment [7]. Overall, there is still no absolute consensus as to the etiology of HS, but the hair follicle likely plays an integral role.…”

Section: Resultsmentioning

confidence: 90%

“…recent evidence actually suggests that involvement of the follicle and thus the pilosebaceous unit is the primary event and apocrine gland involvement is a secondary phenomenon. Studies based on histopathology describe a series of events similar to the pathogenesis of acne with hyperkeratinization of the follicle leading to dilation and rupture causing dermal inflammation and bacterial colonization, sinus tract formation, and eventually scarring [7]. These similarities between the two disorders have led to the suggestion of acne inversa as a more appropriate description than HS [8].…”

Section: Resultsmentioning

confidence: 99%

Efficacy of Nd:YAG Laser for the Treatment of Hidradenitis Suppurativa

Nosrati¹,

Hunter²,

Kelly³

2012

JCDSA

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Hidradenitis suppurativa (HS) is an inflammatory skin disease that involves sebaceous glands and hair follicles of intertriginous areas, including axillary and inguinal regions. It is often chronic, painful, disabling, and can worsen over time. Besides surgically excising affected areas, effective treatments are currently lacking. The long-pulsed neodymium:yttrium-aluminium-garnet (Nd:YAG) laser is a device that has traditionally been used for hair removal, but has recently shown promise in clearing old lesions of HS and preventing new eruptions. In accordance with studies in the current literature, we hypothesize that the Nd:YAG laser will significantly improve subjects with hidradenitis suppurativa compared to standard, uninvasive treatment with topical antibiotics [1,2]. Study aims include: to treat subjects with hidradenitis suppurativa with Nd:YAG laser therapy once monthly for 3 consecutive months, with a one month followup; to compare the effectiveness of Nd:YAG treatment on one side of the subject (e.g., right) to treatment with topical antibiotics on the subject's other side (e.g., left); to assess treatment response using a visual analogue scale; to assess subject satisfaction with treatment using a questionnaire; and to photodocument treatment response at each visit.

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Hidradenitis suppurativa: a disease of the absent sebaceous gland? Sebaceous gland number and volume are significantly reduced in uninvolved hair follicles from patients with hidradenitis suppurativa

Abstract: Our results suggest that the absence or reduced volume of the sebaceous gland may play a role in the pathogenesis of HS. The presence of fibrosis suggests that sebaceous glands are obliterated early in the pathogenesis of HS.

Cited by 123 publications

References 37 publications

Beyond acne: Current aspects of sebaceous gland biology and function

Beyond acne: Current aspects of sebaceous gland biology and function

Mechanical stress and the development of pseudo‐comedones and tunnels in Hidradenitis suppurativa/Acne inversa

Efficacy of Nd:YAG Laser for the Treatment of Hidradenitis Suppurativa

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