Hidradenitis suppurativa and association with stroke: systematic review and meta-analysis

Phan, Kevin; Ng, William Hao Syuen; Lai, Belinda; Garg, Amit; Smith, Saxon D

doi:10.1080/09546634.2021.1959502

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…In another review, Gau [28] found that in five observational studies involving 402,021 participants, HS patients had a 2.63-fold increased risk of renal diseases (95% CI 2.03-3.42). Phan et al [29] reported in their review of six case-control studies that HS patients reported a significantly greater proportion of strokes than the control ((OR 1.74; 95% CI 1.45-2.09; p < 0.00001). Lastly, another review of five case-control studies found that 36,103 HS cases had a significant association with thyroid disease (OR 1.36; 95% CI 1.13-1.64, p = 0.001), compared to the 170,517 control cases.…”

Section: Pathophysiologymentioning

confidence: 98%

“…Despite the precise underlying mechanisms remaining unknown, previous studies posit that factors such as genetic susceptibility, immune dysfunction, and cytokine dysregulation may have contributed to the comorbidities between HS and inflammatory arthritis, bowel diseases, allergic diseases, stroke, thyroid disease, and renal diseases [18,[26][27][28][29]. Almuhanna et al [26] reported that compared to 385,599 controls, the 200,361 HS patients had a significantly higher risk of inflammatory arthritis (OR 3.44; 95% CI 1.92-6.17), the association between HS and spondyloarthritis (OR 2.10; 95% CI 1.40-3.15), and the association between HS and rheumatoid arthritis (OR 1.89; 95% CI 1.14-3.12).…”

Section: Pathophysiologymentioning

confidence: 99%

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Hidradenitis Suppurativa: Molecular Etiology, Pathophysiology, and Management—A Systematic Review

Diaz,

Aflatooni,

Abdi

et al. 2023

CIMB

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Hidradenitis suppurativa is a chronic inflammatory skin condition that affects the hair follicles in areas of the body with apocrine glands. The condition is characterized by recurrent, painful nodules, abscesses, and draining sinuses that can lead to scarring and disfigurement. In this present study, we provide a focused evaluation of recent developments in hidradenitis suppurativa research, including novel therapeutics and promising biomarkers that may facilitate clinical diagnosis and treatment. We conducted a systematic review of controlled trials, randomized controlled trials, meta-analyses, case reports, and Cochrane Review articles in accordance with the PRISMA guidelines. The Cochrane Library, PubMed, EMBASE, and Epistemonikos databases were queried via Title/Abstract screen. Eligibility criteria included the following: (1) has a primary focus on hidradenitis suppurativa, (2) includes measurable outcomes data with robust comparators, (3) details the sample population, (4) English language, and (5) archived as full-text journal articles. A total of 42 eligible articles were selected for review. Qualitative evaluation identified numerous developments in our understanding of the disease’s multiple potential etiologies, pathophysiology, and treatment options. It is important for individuals with hidradenitis suppurativa to work closely with a healthcare provider to develop a comprehensive treatment plan that addresses their individual needs and goals. To meet this objective, providers must keep current with developments in the genetic, immunological, microbiological, and environmental factors contributing to the disease’s development and progression.

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Section: Pathophysiologymentioning

confidence: 98%

Section: Pathophysiologymentioning

confidence: 99%

Hidradenitis Suppurativa: Molecular Etiology, Pathophysiology, and Management—A Systematic Review

Diaz,

Aflatooni,

Abdi

et al. 2023

CIMB

View full text Add to dashboard Cite

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[Artículo traducido] Factores determinantes de la severidad de la enfermedad en los pacientes con hidradenitis supurativa evaluados en un hospital español durante un periodo de 5 años

Melgosa Ramos,

García Ruíz,

Aguado Vázquez

et al. 2024

Actas Dermo-Sifiliográficas

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Laboratory and clinical haemostatic aberrations in primary dermatologic disease: A review

Sharma,

Thomas,

Moody

et al. 2024

Thrombosis J

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Inflammatory dermatologic diseases have long been viewed as a “skin limited” disease process. Current literature on inflammatory dermatologic diseases investigates their relationship and influence on thromboembolic states and thromboembolic complications and the understanding of their pathophysiology and molecular mechanisms. Studies specifically discuss known inflammatory skin diseases including alopecia areata, vitiligo, psoriasis, hidradenitis suppurativa, atopic dermatitis, chronic spontaneous urticaria, and autoimmune bullous diseases, and their effects on systemic inflammation, associated cardiovascular comorbidities, and thromboembolic or hypercoagulable states. The limited current literature shows potential for links between inflammatory skin diseases and hypercoagulable states. Biomarkers such as F1 + 2, D-dimer, eosinophilic cationic protein, and PAI-1 are currently being studied to outline the mechanisms connecting inflammatory skin disease to the coagulation system. Further study and larger amounts of data are needed to draw definitive conclusions, especially when interpreting biomarkers alone such as PAI-1. The mechanisms, rates of systemic inflammation, and clinical outcomes of traditionally “skin limited” inflammatory diseases remain chronically understudied in dermatology. Many organ systems have well established connections between inflammatory disease and hypercoagulable states, but there are significant gaps in the literature regarding skin diseases. There is a significant need for comprehensive investigation of molecular mechanisms behind inflammatory dermatologic disease and hypercoagulability, how hypercoagulability effects clinical outcomes, and proper intervention to optimize patient outcomes.

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Hidradenitis suppurativa and association with stroke: systematic review and meta-analysis

Cited by 3 publications

References 26 publications

Hidradenitis Suppurativa: Molecular Etiology, Pathophysiology, and Management—A Systematic Review

Hidradenitis Suppurativa: Molecular Etiology, Pathophysiology, and Management—A Systematic Review

[Artículo traducido] Factores determinantes de la severidad de la enfermedad en los pacientes con hidradenitis supurativa evaluados en un hospital español durante un periodo de 5 años

Laboratory and clinical haemostatic aberrations in primary dermatologic disease: A review

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