Hidradenitis suppurativa. Glucose tolerance, clinical, microbiologic, and immunologic features and HLA frequencies in 27 patients

O'Loughlin, S

doi:10.1001/archderm.124.7.1043

Cited by 33 publications

(40 citation statements)

References 9 publications

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“…One study has suggested that inherited factors may be important in hidradenitis following HLA-typing in 27 patients, although the results did not reach statistical significance due to the small number of patients used. 35 A later and larger study of HLA in Swedish patients compared with a population sample did not find any HLA-A, HLA-B, HLA-DR association. 36 One study describing an autosomal dominant pattern of inheritance has also been reported, but the penetrance appeared variable, indicating that other nongenetic factors are involved.…”

Section: Etiology and Pathogenic Factorsmentioning

confidence: 83%

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Hidradenitis Suppurativa

Jemec

2002

JCMS

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Section: Etiology and Pathogenic Factorsmentioning

confidence: 83%

“…milleri, Bilophila wadsworthia, and anaerobes. 35,[77][78][79][80][81][82] The species have been isolated from a wide range of lesions at many different stages and definitions of hidradenitis. Frequently, the different species of bacteria have also been found in only a few cases as a G.B.E.…”

Section: Infectionmentioning

confidence: 99%

Hidradenitis Suppurativa

Jemec

2002

JCMS

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“…Apart from a few published studies (GiamarellosBourboulis et al 2007, Lapins et al 2001, O'Loughlin et al 1988, Wortsman et al 2009), there are still missing data regarding the immune processes that occur in HS. We do not know, unlike in other dermatoses (e.g.…”

Section: Introductionmentioning

confidence: 99%

Soluble interleukin-2 receptor serum level is a useful marker of hidradenitis suppurativa clinical staging

2009

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Hidradenitis suppurativa (HS) is a recurrent, debilitating suppurative skin disease. The major challenge is the choice of optimal treatment. Assessment of treatment effectiveness is currently associated with clinical observations of disease activity based on Hurley's or Sartorius' grading system. Detailed examination of patients with HS and evaluation of disease severity is frequently time-consuming and undoubtedly subjective. With regard to these factors, there is a need for laboratory findings that will help resolve the problem. The aim of this study was to determine the usefulness of soluble interleukin-2 receptor (sIL-2R) serum concentration as a marker of HS clinical staging and comparative analysis with the commonly conducted laboratory measurements, including white blood cell count, C-reactive protein and erythrocyte sedimentation rate. The statistical analysis of all these laboratory parameters conducted within a group of 54 individuals with HS revealed that sIL-2R serum level seems to be the most sensitive measurement for evaluation of disease stage. Moreover, the existence of strong dependences between sIL-2R serum concentration and Hurley's HS grading system were demonstrated. In conclusion, we believe that sIL-2R serum level could be used as a valuable marker for disease staging in patients with HS.

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“…O' Loughlin et al (10) found that 7 of 27 patients with moderate or severe clinical disease had a marked reduction in peripheral T lymphocytes (i.e. 43%) and an increased frequency of the HLA antigens A1 and B8; however, the differences were not signi® cant.…”

Section: Discussionmentioning

confidence: 99%

“…In a previous study using serological tissue-typing techniques, no signi® cant increases in the HLA-A and -B speci® cities were found in 27 Irish patients with HS (10).…”

mentioning

confidence: 80%

No Human Leukocyte Antigen-A, -B or -DR Association in Swedish Patients with Hidradenitis Suppurativa

Lapins¹,

Olerup²,

Emtestam³

2001

Acta Dermato-Venereologica

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Hidradenitis suppurativa (HS) is a cicatrizing, inflammatory and recurrent disease restricted to inverse skin, such as that of the axilla and groin of younger adults. In a previous study, using serological tissue-typing techniques, no significant increases in the human leukocyte antigen (HLA)-A and -B specificities were found in patients with HS. The aim of this study was to determine the frequencies of HLA-A, -B and, for the first time, HLA-DR alleles, using genomic tissue-typing methods in patients with HS. Forty-two unrelated Swedish patients with HS were included and compared with 250 controls. According to clinical staging adopted from Hurley all of the patients had stage II HS, i.e. recurrent abscesses with tract formation and cicatrization and single or multiple widely separated lesions. No association with HLA-A, -B or -DRB1 alleles was found in patients with HS. Genetic factors associated with the HLA class I or II regions do not appear to contribute significantly to the possible genetic susceptibility of HS.

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Hidradenitis suppurativa. Glucose tolerance, clinical, microbiologic, and immunologic features and HLA frequencies in 27 patients

Cited by 33 publications

References 9 publications

Hidradenitis Suppurativa

Hidradenitis Suppurativa

Soluble interleukin-2 receptor serum level is a useful marker of hidradenitis suppurativa clinical staging

No Human Leukocyte Antigen-A, -B or -DR Association in Swedish Patients with Hidradenitis Suppurativa

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