Hidradenitis suppurativa (HS)

Abstract

Hidradenitis suppurativa (HS) is an autoinflammatory skin disease affecting roughly 1-4% worldwide. Symptoms of HS include abscesses, sinus tracts and scarring, which can cause immense pain and discomfort for patients. The disease impacts the pilosebaceous units in apocrine gland-bearing regions with skin-to-skin contact. Thus far, the cause of HS is unknown, however, hyperkeratosis of the follicular epithelium is most likely the first event in the development of HS lesions. Current treatment options range from topical-and systemic treatments, light therapy, and biological agents to surgical intervention. These therapies do not warrant optimal results; therefore, the aim of this report is to choose new potential drug targets.In that respect, we present specific isoforms of aquaporins (AQP3 and AQP5) and matrix metalloproteinases (MMP-2, MMP-8, and MMP-9) as possible targets that may be involved in the early and late stages of HS, respectively. Although the particular roles of AQP3 and AQP5