Hidradenitis suppurativa in Down’s syndrome: A case report

Toodayan, Nadeem

doi:10.7241/ourd.20153.87

Cited by 2 publications

(3 citation statements)

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“…Thirteen studies in literature have highlighted HS in individuals with PS, SMS, and DS 2–5,8–16 . Our case report documents the fourth patient with PS to have been diagnosed with HS.…”

Section: Discussionmentioning

confidence: 62%

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Hidradenitis suppurativa and chromosomal abnormalities: a case report and systematic review of the literature

et al. 2020

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Hidradenitis suppurativa (HS) is a chronic inflammatory follicular disorder that involves painful nodules, abscesses, and tunnels of intertriginous sites. Although the etiology has not been fully elucidated, recent studies have highlighted its association with chromosomal abnormalities.We present a rare case of HS in a patient with Trisomy 1q;13 and systematically summarize the association between HS and chromosomal abnormalities. A search was conducted using MEDLINE and EMBASE in OVID database. Original studies reporting HS among human subjects with chromosomal abnormalities were included. Patient demographics, disease symptomology, clinical features, and treatment histories were extracted and summarized.Thirteen studies describing 428 cases met the inclusion criteria. Of the 13 articles, nine studies reported patients with HS and Down syndrome (DS), one article investigated HS and Smith–Magenis syndrome (SMS), and three articles analyzed HS and Patau syndrome (PS). While increased prevalence of HS was found in populations with DS, with suggested mechanisms involving amyloid precursor protein cleavage product, keratinocyte proliferation, and follicular plugging, the associations between HS and both SMS and PS remain inconclusive because of limited studies with small sample size.Although evidence suggests that the genetic regulation of chromosome 21 may be implicated in the association between HS and DS, this association may be confounded by additional factors that increase the risk of HS. Further research with larger sample sizes must be conducted to strengthen our understanding of the association between HS and chromosomal abnormalities.

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“…Thirteen studies in literature have highlighted HS in individuals with PS, SMS, and DS 2–5,8–16 . Our case report documents the fourth patient with PS to have been diagnosed with HS.…”

Section: Discussionmentioning

confidence: 62%

“…Thirteen studies met inclusion criteria (seven case reports/case series, three cross‐sectional studies, and three retrospective studies), outlining the clinical details of 428 cases presenting with HS in addition to a chromosomal abnormality (Table 1). 2–5,8–16 …”

Section: Resultsmentioning

confidence: 99%

Hidradenitis suppurativa and chromosomal abnormalities: a case report and systematic review of the literature

et al. 2020

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“…Patients were most frequently treated with tetracyclines and flucloxacillin . Surgery was also used; however, the reports are vague regarding the effects of treatments.…”

Section: Down's Syndromementioning

confidence: 99%

Recognizing syndromic hidradenitis suppurativa: a review of the literature

Gasparic

Riis

Jemec

2017

Acad Dermatol Venereol

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Hidradenitis suppurativa (HS) is an inflammatory skin disease causing painful inflammation and suppuration. It may occur in rare syndromes: follicular occlusion, Bazex-Dupré-Christol, Down's, KID, PAPASH, PASS, PASH, and SAPHO syndromes, as well as Dowling-Degos disease. An overview of syndromic HS may inform the search for aetiological factors in HS. PubMed, Ovid and Web of Science were systematically searched using '(hidradenitis OR acne invers*) AND (syndrome OR KID OR PASS OR PAPA OR PASH OR SAPHO OR bazex-dupre OR 'dowling degos' OR triad OR tetrad)' and Cochrane Library using 'hidradenitis OR acne invers*'. A total of 82 articles were included in the final review. We summarize 134 cases collected from the 82 included articles. The syndromes are discussed, focusing on etiopathogenesis, clinical presentation and treatment. This study is based on case reports; therefore, conclusions may be subject to the selection bias. These syndromes are rare; however, it is important to recognize them, as treating them may require a different approach. Three subtypes of syndromic hidradenitis are suggested: syndromes with known genetic abnormalities, syndromes characterized by follicular plugging or structural defects, and syndromes with possible autoinflammatory pathogenesis. There was no universally effective treatment for syndromic HS, and treatment was individualized.

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Hidradenitis suppurativa in Down’s syndrome: A case report

Cited by 2 publications

References 0 publications

Hidradenitis suppurativa and chromosomal abnormalities: a case report and systematic review of the literature

Hidradenitis suppurativa and chromosomal abnormalities: a case report and systematic review of the literature

Recognizing syndromic hidradenitis suppurativa: a review of the literature

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