Hidradenitis Suppurativa in Down Syndrome: A Case Series

Hamadah, Issam; Haider, Mansoor A.; Chisti, Muzamil; Binamer, Yousef

doi:10.1111/pde.13188

Cited by 11 publications

(27 citation statements)

References 14 publications

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“…This finding is comparable with that of other authors [12] who detected a younger age in patients with HS and DS compared to those without DS (17.9 vs. 33.9 years; p < 0.001). In line with previous studies [10, 12], our 9 patients with HS and DS had a mild severity of the disease (Hurley stage I in 7 cases and Hurley stage II in 2 cases) and therefore they had been treated with topical corticosteroids and antibiotics, achieving a good control of the disease. No significant differences concerning sex, BMI, and comorbidities were found between patients with HS and DS compared to patients with HS only (Table 2).…”

Section: Discussionsupporting

confidence: 60%

“…HS-related syndromes could be classified into three groups based on (1) the specific genetic background (presence of a pathognomonic test), (2) the presence of follicular plugging or structural disorders, and (3) a possible autoinﬂammatory pathogenesis. A syndromic condition including both HS and DS, and belonging to group 1, has been previously described, but only in a few studies [10-16]. In a retrospective study, Denny and Anadkat [12] found that 16 of 667 (2.4%) patients with HS were concomitantly affected by DS, showing that the prevalence of DS was about 29 times higher in HS patients compared to the general population.…”

Section: Discussionmentioning

confidence: 99%

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Hidradenitis Suppurativa Associated with Down Syndrome Is Characterized by Early Age at Diagnosis

Giovanardi¹,

Chiricozzi

Bianchi

et al. 2018

Dermatology

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Background/Aims: The association between hidradenitis suppurativa (HS) and multiple comorbidities has been widely investigated but data about the coexistence of Down syndrome (DS) are scarce. We sought to evaluate the prevalence of DS among a population of HS patients and assess their clinical features. Methods: We collected demographic and clinical data of patients affected with HS referred to three Italian outpatient dermatology clinics. Results: A total of 257 HS patients were enrolled, 62% females and 38% males (mean age [±SD]: 23.3 ± 10.7 years); 9 of the 257 patients (3.5%), 7 females and 2 males, had concomitant HS and DS. The patients with DS and HS had a significantly earlier age of onset (mean age: 14.3 ± 3.6 vs. 23.4 ± 12.31 years; p = 0.029), a significantly younger age at diagnosis (mean age: 21.1 ± 11.1 vs. 31.8 ± 13.5 years; p = 0.015), and were significantly younger (mean age: 23.3 ± 10.7 vs. 34.6 ± 13.07 years; p = 0.005). No significant differences about other clinical data were found between the two groups. Conclusion: The prevalence of DS in HS patients corresponds to a not negligible 3.5% of cases, who experienced an onset of HS at a younger age compared to patients with HS only.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Hidradenitis Suppurativa Associated with Down Syndrome Is Characterized by Early Age at Diagnosis

Giovanardi¹,

Chiricozzi

Bianchi

et al. 2018

Dermatology

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“…However, evidences are as follows: (i) family history is often negative; (ii) HS is more frequent in females; (iii) the age of HS onset is early; (iv) BMI values are often high; (v) the location of the lesions is more frequently below the diaphragm and (vi) the severity of HS is often mild . No conclusive data are available about the prevalence of HS in patients with DS; it ranged from 2.1% in a population‐based cross‐sectional analysis carried out in United States, to 3.5% in an Italian study, to 14.6% in a French cross‐sectional study and to 38% in a Saudi Arabian study . As regards the ethnicity, according to a study carried out in United States, HS was more frequent in non‐Caucasian DS subjects .…”

Section: Case Seriesmentioning

confidence: 99%

“…3,4,7 No conclusive data are available about the prevalence of HS in patients with DS; it ranged from 2.1% in a populationbased cross-sectional analysis carried out in United States, 6 to 3.5% in an Italian study, 7 to 14.6% in a French cross-sectional study 8 and to 38% in a Saudi Arabian study. 4 As regards the ethnicity, according to a study carried out in United States, HS was more frequent in non-Caucasian DS subjects. 3 However, in another American study, HS was more common in Caucasians with DS.…”

Section: Case Seriesmentioning

confidence: 99%

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Hidradenitis suppurativa in patients with Down syndrome

Veraldi

Guanziroli

Benzecry

et al. 2019

Acad Dermatol Venereol

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Literature data about hidradenitis suppurativa (HS) in patients with Down syndrome (DS) are limited. In this retrospective study, 6 (4M/2F; mean age: 18.7 years) out of 313 patients affected by HS (1.9%) had DS. The age of appearance of HS was from 9 to 14 years. No family history of HS was present. BMI ranged from 20.1 to 29.9. In all patients, HS was located below the diaphragm. Five out of six patients were staged as Hurley II severity.

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Hidradenitis suppurativa and chromosomal abnormalities: a case report and systematic review of the literature

et al. 2020

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Hidradenitis suppurativa (HS) is a chronic inflammatory follicular disorder that involves painful nodules, abscesses, and tunnels of intertriginous sites. Although the etiology has not been fully elucidated, recent studies have highlighted its association with chromosomal abnormalities.We present a rare case of HS in a patient with Trisomy 1q;13 and systematically summarize the association between HS and chromosomal abnormalities. A search was conducted using MEDLINE and EMBASE in OVID database. Original studies reporting HS among human subjects with chromosomal abnormalities were included. Patient demographics, disease symptomology, clinical features, and treatment histories were extracted and summarized.Thirteen studies describing 428 cases met the inclusion criteria. Of the 13 articles, nine studies reported patients with HS and Down syndrome (DS), one article investigated HS and Smith–Magenis syndrome (SMS), and three articles analyzed HS and Patau syndrome (PS). While increased prevalence of HS was found in populations with DS, with suggested mechanisms involving amyloid precursor protein cleavage product, keratinocyte proliferation, and follicular plugging, the associations between HS and both SMS and PS remain inconclusive because of limited studies with small sample size.Although evidence suggests that the genetic regulation of chromosome 21 may be implicated in the association between HS and DS, this association may be confounded by additional factors that increase the risk of HS. Further research with larger sample sizes must be conducted to strengthen our understanding of the association between HS and chromosomal abnormalities.

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Hidradenitis Suppurativa in Down Syndrome: A Case Series

Abstract: The presence of hidradenitis suppurativa in 38% of patients with Down syndrome is far higher than would be expected by chance alone.

Cited by 11 publications

References 14 publications

Hidradenitis Suppurativa Associated with Down Syndrome Is Characterized by Early Age at Diagnosis

Hidradenitis Suppurativa Associated with Down Syndrome Is Characterized by Early Age at Diagnosis

Hidradenitis suppurativa in patients with Down syndrome

Hidradenitis suppurativa and chromosomal abnormalities: a case report and systematic review of the literature

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