Hidradenitis suppurativa treated with finasteride

Joseph, Mary; Jayaseelan, Elizabeth; Ganapathi, B.; Stephen, John

doi:10.1080/09546630510031403

Cited by 98 publications

(88 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To date, the use of finasteride has been reported in 12 HS patients-eight adults and four children. Seven adult patients showed a good response on 5 mg finasteride daily after a treatment period of 2-12 weeks [127,128]. Two patients showed recurrence 1 month after discontinuation.…”

Section: Finasteridementioning

confidence: 97%

See 1 more Smart Citation

An Update on Medical Treatment Options for Hidradenitis Suppurativa

Deckers

Prens

2015

Drugs

View full text Add to dashboard Cite

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent inflammatory nodules mostly located in the armpits and groin. Over the years multiple treatments for HS have been proposed; however, to date a cure is still lacking. In this update we provide an overview of most drug treatments reported on for HS, where possible with their mode of action and side effects. In mild cases, clindamycin lotion or resorcinol cream have proven effective. Tetracyclines are a first-line systemic option in more widespread or severe cases, followed by the combination of clindamycin and rifampicin. However, the recurrence rate is high after discontinuation of clindamycin plus rifampicin combination therapy. Long-term treatment with retinoids, especially acitretin is feasible, although teratogenicity has to be taken into account in females of reproductive age. Multiple antiinflammatory drugs have been suggested for HS, such as dapsone, fumarates or cyclosporine. However, their effectiveness in HS is based on small case series with varying results. If most common treatments have failed, biologics (e.g., infliximab or adalimumab) are the next step. Although not addressed in this review, surgical interventions are often needed to achieve remission. Key PointsHidradenitis suppurativa (HS) is a chronic inflammatory skin disease without a cure.Antibiotics (topical or oral) are often the first treatment option for HS.In cases of more extensive or therapy-resistant HS, biologicals (e.g., infliximab or adalimumab) are a good therapeutic option.

show abstract

Section: Finasteridementioning

confidence: 97%

“…The four female children were treated with finasteride 1.25-10 mg daily with good effect. However, all received additional treatment with oral contraceptives, antibiotics, or surgery [128,129].…”

Section: Finasteridementioning

confidence: 99%

An Update on Medical Treatment Options for Hidradenitis Suppurativa

Deckers

Prens

2015

Drugs

View full text Add to dashboard Cite

show abstract

“…10 Other case series have also shown therapeutic benefit for antiandrogens in some patients with HS. [11][12][13] Finasteride is a competitive inhibitor of the type II 5␣-reductase enzyme, which converts testosterone to dihydrotestosterone, resulting in decreased serum dihydrotestosterone levels. Type II 5␣-reductase is found in hair follicles, whereas type I 5␣-reductase is present in both hair follicles and apocrine glands.…”

Section: Commentmentioning

confidence: 99%

“…12 To our knowledge, no long-term safety studies for finasteride have been performed in the pediatric population. Studies in adults examining the effects of finasteride on sperm count and motility showed no significant effect after 1 year of treatment, 23 but there have been a few case reports of reversible negative effects on spermatogenesis and 2 reports of an association with infertility.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Finasteride for the Treatment of Hidradenitis Suppurativa in Children and Adolescents

Randhawa

Hamilton²,

Pope³

2013

JAMA Dermatol

View full text Add to dashboard Cite

Importance: Hidradenitis suppurativa (HS) is a chronic debilitating cutaneous disease for which there is no universally effective treatment. Patients typically present at puberty with tender subcutaneous nodules that can progress to dermal abscess formation. Antiandrogens have been used in the treatment of HS, and studies have primarily focused on adult patients.Observations: We present a case series of 3 pediatric patients with HS who were successfully treated with oral finasteride, resulting in decreased frequency and severity of disease flares with no significant adverse effects. Conclusions and Relevance:Finasteride is a therapeutic option that provides benefit for pediatric patients with HS. Further prospective data and randomized controlled studies will provide helpful information in the management of this disease.

show abstract