Hidradenitis suppurativa treated with tetracycline in combination with colchicine: a prospective series of 20 patients

Abstract

This study indicates that the combination of the anti-inflammatory actions of colchicine and minocycline is effective in disease control in HS. Colchicine emerged as a safe option for the maintenance of the obtained result.

North American clinical management guidelines for hidradenitis suppurativa: A publication from the United States and Canadian Hidradenitis Suppurativa Foundations

“…2 Minocycline has been evaluated only in combination with colchicine, making its utility unclear. 9 Similarly, doxycycline, 100 mg twice daily, was used in combination with adalimumab or placebo in a subset of…”

“…[28][29][30][31][32][33]103 The mean dose ranged from 0.5 to 1 mg/kg/d, with the mean duration ranging from 4 to 10 months. Hurley stages were mostly unreported and outcome measures varied Rifampin 1 clindamycin B II [10][11][12][13][14][15][16] Rifampin 1 moxifloxacin 1 metronidazole C II 17 Dapsone C III 18,19 Ertapenem C III 20,21 Hormonal therapies Antiandrogen contraceptives C II 22,23 Spironolactone C III 24 Metformin C III 25 Finasteride C III 26 Retinoids Isotretinoin B II [27][28][29][30][31][32] Acitretin B II [33][34][35][36] Alitretinoin B II 37 Systemic immunomodulators Methotrexate Not recommended III 38 Azathioprine Not recommended III 39 Colchicine C (in combination with minocycline only) III 9,40 Cyclosporine C III [41][42][43][44][45] Systemic steroids C* III 46,…”

Quality of life measurement in hidradenitis suppurativa: position statement of the European Academy of Dermatology and Venereology task forces on Quality of Life and Patient‐Oriented Outcomes and Acne, Rosacea and Hidradenitis Suppurativa

“…38,39 There were five publications on surgical treatment, [40][41][42][43][44] one study on combination of surgical treatment with photodynamic therapy 45 and two other studies on photodynamic therapy. 46,47 There were three studies on antibiotics, [48][49][50] single studies on metformin, 51 PUVA, 52 hyperbaric oxygen therapy, 53 alitretinoin, 54 acitretin, 55 ankinra, 56 apremilast, 57 oral zinc gluconate combined with topical triclosan 58 and verapamil. 59 Detailed information on clinical trials that included ten or more HS patients is presented in Table 1.…”

T helper 17 cell/regulatory T-cell imbalance in hidradenitis suppurativa/acne inversa: the link to hair follicle dissection, obesity, smoking and autoimmune comorbidities

“…Tetracyclines, alone or in combination, have been used for the systemic treatment of HS . In various animal models, tetracyclines decreased Th17 differentiation and reduced IL‐17 levels …”

“…140 Tetracyclines, alone or in combination, have been used for the systemic treatment of HS. 141,142 In various animal models, tetracyclines decreased Th17 differentiation and reduced IL-17 levels. [143][144][145][146] Retinoids Retinoids exert beneficial effects in the treatment of HS.…”