Hidradenocarcinoma involving the male breast: Report of a case with emphasis on the differential diagnosis of invasive carcinoma with sweat gland differentiation

Kang, Eun Young; Fisher, Sarah B.; Middleton, Lavinia P.

doi:10.1016/j.hpr.2023.300698

Cited by 2 publications

(3 citation statements)

References 23 publications

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“…According to the literature, mainly due to its remarkably low incidence of 0.05%, less than 60 cases of hidradenocarcinoma have been reported [10]. Of those, only 11 articles concern instances of breast involvement [1,5,6,8,[11][12][13][14][15][16][17]. Given that the diagnosis of hidradenocarcinoma relies on histological and immunohistochemical characteristics, these features have become the primary focus in the reported cases thus far.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, Ki-67 proliferation index staining higher than 11% and a mitotic index over four mitoses per 10 high-power field (HPF) are features often present in the malignant variant of hidradenoma [ 19 ]. As of now, there have been no identified histologic characteristics that can serve as reliable indicators to predict hidradenocarcinoma aggressive behavior [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…Although a fraction of hidradenocarcinomas can arise from the malignant transformation of pre-existing benign clear-cell hidradenomas, the majority occur de novo [ 5 ]. Commonly asymptomatic, hidradenocarcinomas of the breast appear as well demarcated firm nodular lesions, close to the nipple-areola complex, arising mainly from the dermis or less frequently from the breast parenchyma [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Hidradenocarcinoma of the Female Breast: A Surgical Approach to a Rare Skin Tumor

Alves¹,

Araújo²,

Sousa³

et al. 2023

Cureus

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Clear-cell hidradenocarcinomas are extremely uncommon sweat gland tumors with a predilection for the head and neck. In the limited number of articles reporting breast involvement, the primary focus concerns this entity's histological and immunohistochemical characteristics.Since hidradenocarcinomas of the breast have the potential to resemble a primary breast carcinoma closely, diagnosis may be challenging. Therefore, the authors report the first case of hidradenocarcinoma of the breast, which features its macroscopic morphology. In addition, to increase physicians' awareness of this rare neoplasm, the article also aims to detail its surgical approach.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hidradenocarcinoma of the Female Breast: A Surgical Approach to a Rare Skin Tumor

Alves¹,

Araújo²,

Sousa³

et al. 2023

Cureus

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Hidradenocarcinoma of the Chest With Axillary Lymph Node Metastasis: Report of 2 Cases and Systematic Literature Review of a Breast Cancer Mimicker

Fortarezza,

Maggioni,

Colagrande

et al. 2024

The American Journal of Dermatopathology

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Hidradenocarcinoma (HAC) is a rare malignant neoplasm originating from eccrine sweat glands, often presenting diagnostic challenges because of its resemblance to other malignancies, particularly breast cancer when occurring in the chest region. This report describes 2 cases of HAC with axillary lymph node metastasis, both initially misinterpreted clinically. The first case involved a 63-year-old woman with a sternal mass, near the right breast, initially suspected to be a sebaceous cyst. Histologic examination revealed a solid-cystic epithelial tumor with features suggestive of HAC, confirmed by immunohistochemical analysis. The second case concerned an 81-year-old woman with a subcutaneous growth in the sternal area, also diagnosed as HAC after histopathologic and immunohistochemical assessment. Both cases demonstrated strong estrogen receptor positivity, leading to the recommendation of hormonal therapy. A systematic review of the literature identified 21 similar cases of HAC in the chest wall, highlighting the diagnostic complexities and the potential for these tumors to mimic breast carcinoma. This review underscores the need for careful histologic and immunohistochemical evaluation to differentiate HAC from other malignancies, particularly in the breast region. Given the rare and the potential aggressive nature of HAC, early and accurate diagnosis is crucial for guiding appropriate therapeutic strategies and improving patient outcomes.

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Hidradenocarcinoma involving the male breast: Report of a case with emphasis on the differential diagnosis of invasive carcinoma with sweat gland differentiation

Cited by 2 publications

References 23 publications

Hidradenocarcinoma of the Female Breast: A Surgical Approach to a Rare Skin Tumor

Hidradenocarcinoma of the Female Breast: A Surgical Approach to a Rare Skin Tumor

Hidradenocarcinoma of the Chest With Axillary Lymph Node Metastasis: Report of 2 Cases and Systematic Literature Review of a Breast Cancer Mimicker

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