Pressure vessels are frequently fabricated using composite materials which stand out with their high strength-to-weight ratio, and provide considerable advantages compared to conventional steel ones. In our previous study, the impacts of Polar Opening Radius (POR) on the mechanical characteristics of Composite Overwrapped Pressure Vessels COPVs were numerically examined, and it was determined that effective volume and structural weight responses improved with higher POR, but significant deterioration took place in first-ply interlaminar shear stress (ILSS) responses after 20 mm POR. Therefore, to achieve the best possible mechanical and structural behaviors, the present study aimed to discover an optimum POR that provides maximum internal volume as well as minimum weight and ILSS responses. In this regard, the optimum geodesic dome trajectory based on the 10–30 mm POR range was determined using the Bees Algorithm (BA) and the Particle Swarm Optimization (PSO). According to the findings, the optimum POR was found as 17.9643 and 17.9671 mm due to the BA and PSO algorithms, respectively. Moreover, first-ply ILSS, structural weight and effective internal volume for the optimal COPVs design were achieved as 52.444 MPa, 1070.81 g, and 2721.94 cm3 from the BA, and thus COPVs with maximum strength and minimum structural weight has been designed. In this way, thanks to the optimization studies, an approximately 18.31% improvement in ILSS responses was achieved despite the negligible deterioration in weight and volume compared to the COPVs with a 30 mm POR.