Hierarchical assembly of dual-responsive biomineralized polydopamine–calcium phosphate nanocomposites for enhancing chemo-photothermal therapy by autophagy inhibition

Wang, Xuan; Li, Yunhao; Cui, Yankun; Deng, Xiongwei; Lu, Jianqing; Fan, Jia; Pan, Zian; Cui, Xinyue; Hu, Fanqi; Hu, Wenhao; Wu, Yan

doi:10.1039/d0bm00142b

Cited by 17 publications

(19 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Yang et al [ 11 ] echoed this notion by suggestive of a synergetic therapy which incorporated an antiglycolytic agent in conjunction with the autophagy inhibitor black phosphorus nanosheet for augmenting tumor-starvation therapy. Such views also have demonstrated in our previous study [ 12 – 14 ].…”

Section: Introductionsupporting

confidence: 88%

Boosting nutrient starvation-dominated cancer therapy through curcumin-augmented mitochondrial Ca2+ overload and obatoclax-mediated autophagy inhibition as supported by a novel nano-modulator GO-Alg@CaP/CO

Wang

Fan

et al. 2022

J Nanobiotechnol

Self Cite

View full text Add to dashboard Cite

Background By hindering energy supply pathway for cancer cells, an alternative therapeutic strategy modality is put forward: tumor starvation therapy. And yet only in this blockade of glucose supply which is far from enough to result in sheer apoptosis of cancer cells. Results In an effort to boost nutrient starvation-dominated cancer therapy, here a novel mitochondrial Ca2+ modulator Alg@CaP were tailor-made for the immobilization of Glucose oxidase for depriving the intra-tumoral glucose, followed by the loading of Curcumin to augment mitochondrial Ca2+ overload to maximize the therapeutic efficiency of cancer starvation therapy via mitochondrial dysfunctions. Also, autophagy inhibitors Obatoclax were synchronously incorporated in this nano-modulator to highlight autophagy inhibition. Conclusion Here, a promising complementary modality for the trebling additive efficacy of starvation therapy was described for cutting off the existing energy sources in starvation therapy through Curcumin-augmented mitochondrial Ca2+ overload and Obatoclax-mediated autophagy inhibition. Graphical Abstract

show abstract

Section: Introductionsupporting

confidence: 88%

Boosting nutrient starvation-dominated cancer therapy through curcumin-augmented mitochondrial Ca2+ overload and obatoclax-mediated autophagy inhibition as supported by a novel nano-modulator GO-Alg@CaP/CO

Wang

Fan

et al. 2022

J Nanobiotechnol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Moreover, based on this strategy, we previously fabricated porous PDA nanoparticles to encapsulate autophagy inhibitor chloroquine (CQ) inside, which resulted in much stronger tumor inhibition combined with PDA nanoparticle-mediated PTT ( Huang et al, 2021 ). Similar results were also obtained by using autophagy inhibitor CQ to inhibit PTT-induced protective autophagy in cancer cells, which led to enhanced tumor inhibition/killing efficiency ( Wang X. et al, 2020 ; Shao et al, 2020 ).…”

Section: Functions Of Pda Nanosystem Mediated Pttsupporting

confidence: 72%

Advances and Potentials of Polydopamine Nanosystem in Photothermal-Based Antibacterial Infection Therapies

et al. 2022

View full text Add to dashboard Cite

Bacterial infection remains one of the most dangerous threats to human health due to the increasing cases of bacterial resistance, which is caused by the extensive use of current antibiotics. Photothermal therapy (PTT) is similar to photodynamic therapy (PDT), but PTT can generate heat energy under the excitation of light of specific wavelength, resulting in overheating and damage to target cells or sites. Polydopamine (PDA) has been proved to show plenty of advantages, such as simple preparation, good photothermal conversion effects, high biocompatibility, and easy functionalization and adhesion. Taking these advantages, dopamine is widely used to synthesize the PDA nanosystem with excellent photothermal effects, good biocompatibility, and high drug loading ability, which therefore play more and more important roles for anticancer and antibacterial treatment. PDA nanosystem-mediated PTT has been reported to induce significant tumor inhibition, as well as bacterial killings due to PTT-induced hyperthermia. Moreover, combined with other cancer or bacterial inhibition strategies, PDA nanosystem-mediated PTT can achieve more effective tumor and bacterial inhibitions. In this review, we summarized the progress of preparation methods for the PDA nanosystem, followed by advances of their biological functions and mechanisms for PTT uses, especially in the field of antibacterial treatments. We also provided advances on how to combine PDA nanosystem-mediated PTT with other antibacterial methods for synergistic bacterial killings. Moreover, we further provide some prospects of PDA nanosystem-mediated PTT against intracellular bacteria, which might be helpful to facilitate their future research progress for antibacterial therapy.

show abstract

“…CP/I were acquired from our previous work. 31 2.3. Characterization of Organic/Inorganic Multifunctional Hybrid Nanocomposites (DPGC/OI).…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, there remains an obstacle underlying that cancer could develop protective mechanisms to skip cell apoptosis in PDT. − It is demonstrated that autophagy would capture and degrade dysfunctional organelles to sustain metabolism and homeostasis. ,, Nevertheless, there is a complex relationship between autophagy and tumor treatment. Collective studies have documented that autophagy has currently exhibited an essential role for cancer cell survival, hindering the success of the current treatment paradigms. − Autophagy inhibition has been accepted as an adjuvant therapy in the context of other therapies, , which has paved the way for the potential combined approach for tumor treatment.…”

Section: Introductionmentioning

confidence: 99%

Colloidally Stabilized DSPE-PEG-Glucose/Calcium Phosphate Hybrid Nanocomposites for Enhanced Photodynamic Cancer Therapy via Complementary Mitochondrial Ca²⁺ Overload and Autophagy Inhibition

Wang

Deng

et al. 2021

ACS Appl. Mater. Interfaces

Self Cite

View full text Add to dashboard Cite

Autophagy inhibition could hinder the underlying protective mechanisms in the course of tumor treatment. The advances in autophagy inhibition have driven focus on the functionalized nanoplatforms by combining the current treatment paradigms with complementary autophagy inhibition for enhanced efficacy. Furthermore, Ca 2+ overload is also a promising adjuvant target for the tumor treatment by augmenting mitochondrial damage. In this view, complementary mitochondrial Ca 2+ overload and autophagy inhibition were first demonstrated as a novel strategy suitable for homing in on the shortage of photodynamic therapy (PDT). We constructed biodegradable tumor-targeted inorganic/organic hybrid nanocomposites (DPGC/OI) synchronously encapsulating IR780 and Obatoclax by biomineralization of the nanofilm method, which consists of pH-triggered calcium phosphate (CP), long circulation phospholipid block copolymers 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE)poly(ethylene glycol) (PEG)2000-glucose (DPG). In the presence of the hydrophilic PEG chain and glucose transporter 1 (Glut-1) ligands, DPGC would become an effectively tumor-oriented nanoplatform. Subsequently, IR780 as an outstanding photosensitizer could produce increased amounts of toxic reactive oxygen species (ROS) after laser irradiation. Calcium phosphate (CP) as the Ca 2+ nanogenerator could generate Ca 2+ at low pH to induce mitochondrial Ca 2+ overload. The dysfunction of mitochondria could enhance increased amounts of ROS. Based on the premise that autophagy would degrade dysfunctional organelles to sustain metabolism and homeostasis, which might participate in resistance to PDT, Obatoclax as an autophagy inhibitor would hinder the protective mechanism from cancer cells with negligible toxicity. Such an enhanced PDT via mitochondrial Ca 2+ overload and autophagy inhibition could be realized by DPGC/OI.

show abstract

Hierarchical assembly of dual-responsive biomineralized polydopamine–calcium phosphate nanocomposites for enhancing chemo-photothermal therapy by autophagy inhibition

Abstract: The induction of autophagy in cancer cells would occur in response to several therapy strategies, including chemotherapy and photothermal therapy (PTT). Hence, combined autophagy inhibition has been regarded as a...

Cited by 17 publications

References 62 publications

Boosting nutrient starvation-dominated cancer therapy through curcumin-augmented mitochondrial Ca2+ overload and obatoclax-mediated autophagy inhibition as supported by a novel nano-modulator GO-Alg@CaP/CO

Boosting nutrient starvation-dominated cancer therapy through curcumin-augmented mitochondrial Ca2+ overload and obatoclax-mediated autophagy inhibition as supported by a novel nano-modulator GO-Alg@CaP/CO

Advances and Potentials of Polydopamine Nanosystem in Photothermal-Based Antibacterial Infection Therapies

Colloidally Stabilized DSPE-PEG-Glucose/Calcium Phosphate Hybrid Nanocomposites for Enhanced Photodynamic Cancer Therapy via Complementary Mitochondrial Ca²⁺ Overload and Autophagy Inhibition

Contact Info

Product

Resources

About

Hierarchical assembly of dual-responsive biomineralized polydopamine–calcium phosphate nanocomposites for enhancing chemo-photothermal therapy by autophagy inhibition

Abstract: The induction of autophagy in cancer cells would occur in response to several therapy strategies, including chemotherapy and photothermal therapy (PTT). Hence, combined autophagy inhibition has been regarded as a...

Cited by 17 publications

References 62 publications

Boosting nutrient starvation-dominated cancer therapy through curcumin-augmented mitochondrial Ca2+ overload and obatoclax-mediated autophagy inhibition as supported by a novel nano-modulator GO-Alg@CaP/CO

Boosting nutrient starvation-dominated cancer therapy through curcumin-augmented mitochondrial Ca2+ overload and obatoclax-mediated autophagy inhibition as supported by a novel nano-modulator GO-Alg@CaP/CO

Advances and Potentials of Polydopamine Nanosystem in Photothermal-Based Antibacterial Infection Therapies

Colloidally Stabilized DSPE-PEG-Glucose/Calcium Phosphate Hybrid Nanocomposites for Enhanced Photodynamic Cancer Therapy via Complementary Mitochondrial Ca2+ Overload and Autophagy Inhibition

Contact Info

Product

Resources

About

Colloidally Stabilized DSPE-PEG-Glucose/Calcium Phosphate Hybrid Nanocomposites for Enhanced Photodynamic Cancer Therapy via Complementary Mitochondrial Ca²⁺ Overload and Autophagy Inhibition