Hierarchical mesoporous NanoMUV-2 for the selective delivery of macromolecular drugs

Abstract

NanoMUV-2 stores high payloads of Paclitaxel and increases its anticancer selectivity.

Synergistic applications of cyclodextrin-based systems and metal–organic frameworks in transdermal drug delivery for skin cancer therapy

“…111 Furthermore, the development of hierarchical mesoporous iron-based MOF, nanostructured MUV-2, showcases the ability of MOFs to store high payloads of macromolecular drugs like paclitaxel, significantly increasing its selectivity towards cancer cells and demonstrating full degradation under simulated physiological conditions while maintaining biocompatibility. 112…”

“…23,92,100,101,114–119 The inclusion of recent advancements in MOF research for wound healing and specific targeting of cancer cells further underscores the potential of MOFs as versatile carriers for drug delivery, opening up new avenues for innovative therapeutic strategies. 111,112 For example, El-Bindary and co-workers have recently reported the preparation of Zr-MOF (synthesized by mixing ZrCl 4 with 2-methylimidazole at basic pH) and ZIF-8 in water and their use to encapsulate doxorubicin. 120,121 The obtained crystals showed in both cases a pH-dependent release, which was accelerated in acidic conditions.…”

“…From a practical point of view, these macromolecules can be obtained through several green synthetic methods: (i) solvent vapor diffusion, (ii) antisolvent method, (iii) mechanochemical approach, (iv) microwave irradiation, (v) hydro/solvothermal method, (vi) impregnation and (vii) ultrasonication. 111–136…”