Hierarchical Nanofeatures Promote Microbial Adhesion in Tropical Grasses: Nanotechnology Behind Traditional Disinfection

Raj, Deena Santhana; Sushmetha, A. M.; Shanker, Jayashree; Saritha, B.; Brindha, P.; Parthasarathy, Meera

doi:10.1007/s12668-015-0164-y

Cited by 1 publication

(1 citation statement)

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“…Table 1 consists of conventional antibiotics currently used for the inhibition of biofilms, although in some cases they are effective, bacteria soon become resistant and in an attempt to reduce harsh harmful chemicals, green alternative therapeutic agents have been studied extensively [14][15][16][17][18][19]. It is of common knowledge since age untold that, medicinal and aromatic plants (MAPs) have antimicrobial properties, thus inclining towards them only seems like the natural course [20][21][22][23][24].…”

Section: Complex Mechanism Of Biofilm Formationmentioning

confidence: 99%

Nanoemulsion as an Effective Inhibitor of Biofilm-forming Bacterial Associated Drug Resistance: An Insight into COVID Based Nosocomial Infections

Raj

Dhamodharan

Thanigaivel

et al. 2022

Biotechnol Bioproc E

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Antibiotic overuse has resulted in the microevolution of drug-tolerant bacteria. Understandably it has become one of the most significant obstacles of the current century for scientists and researchers to overcome. Bacteria have a tendency to form biofilm as a survival mechanism. Biofilm producing microorganism become far more resistant to antimicrobial agents and their tolerance to drugs also increases. Prevention of biofilm development and curbing the virulency factors of these multi drug resistant or tolerant bacterial pathogens is a newly recognised tactic for overcoming the challenges associated with such bacterial infections and has become a niche to be addressed. In order to inhibit virulence and biofilm from planktonic bacteria such as, Pseudomonas aeruginosa , Acinetobacter baumannii , and others, stable nanoemulsions (NEs) of essential oils (EOs) and their bioactive compounds prove to be an interesting solution. These NEs demonstrated significantly greater anti-biofilm and anti-virulence activity than commercial antibiotics. The EO reduces disease-causing gene expression, which is required for pathogenicity, biofilm formation and attachment to the surfaces. Essential NE and NE-loaded hydrogel surface coatings demonstrates superior antibiofilm activity which can be employed in healthcare-related equipments like glass, plastic, and metal chairs, hospital beds, ventilators, catheters, and tools used in intensive care units. Thus, anti-virulence and anti-biofilm forming strategies based on NEs-loaded hydrogel may be used as coatings to combat biofilm-mediated infection on solid surfaces.

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