2018
DOI: 10.1101/415810
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Hierarchical Reconstruction of High-Resolution 3D Models of Human Chromosomes

Abstract: Eukaryotic chromosomes are often composed of components organized into multiple scales, such as nucleosomes, chromatin fibers, topologically associated domains (TAD), chromosome compartments, and chromosome territories. Therefore, reconstructing detailed 3D models of chromosomes in high resolution is useful for advancing genome research. However, the task of constructing quality highresolution 3D models is still challenging with existing methods. Hence, we designed a hierarchical algorithm, called Hierarchical… Show more

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