2023
DOI: 10.3390/cryst13091307
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Hierarchical Structure of Glucosamine Hydrochloride Crystals in Antisolvent Crystallization

Shichao Du,
Chuanping Yu,
Ping Zhang
et al.

Abstract: The crystal morphology of glucosamine hydrochloride (GAH) during antisolvent crystallization was investigated in this work. Particles of different shapes, such as plate-like crystals, leaflike clusters, fan-like dendrites, flower-like aggregates, and spherulites, were produced by tuning the type of antisolvents and crystallization operating conditions. The hierarchical structures of GAH crystals tended to be formed in a water + isopropanol mixture. The effects of operation parameters on the polycrystalline mor… Show more

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Cited by 2 publications
(2 citation statements)
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“…In order to characterize the intermolecular interactions within GABA crystal, we performed Hirshfeld surface analysis and generated two-dimensional fingerprints with the CrystalExplorer 17.5 program, which accepted the structure input file in CIF format . The crystal habit of GABA was predicted by the BFDH model in Materials Studio software . The interaction between the GABA crystal surface and solvent was studied by molecular dynamics (MD) simulation.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…In order to characterize the intermolecular interactions within GABA crystal, we performed Hirshfeld surface analysis and generated two-dimensional fingerprints with the CrystalExplorer 17.5 program, which accepted the structure input file in CIF format . The crystal habit of GABA was predicted by the BFDH model in Materials Studio software . The interaction between the GABA crystal surface and solvent was studied by molecular dynamics (MD) simulation.…”
Section: Methodsmentioning
confidence: 99%
“… 31 The crystal habit of GABA was predicted by the BFDH model in Materials Studio software. 32 The interaction between the GABA crystal surface and solvent was studied by molecular dynamics (MD) simulation. The effect of the additive was also explored via MD simulation.…”
Section: Methodsmentioning
confidence: 99%