Hierarchically porous bioceramics based on geopolymer-hydroxyapatite composite as a novel biomaterial: Structure, mechanical properties and biocompatibility evaluation

Andrade, Rafaela de; Paim, Thaís Casagrande; Bertaco, Isadora; Naasani, Liliana Sous; Buchner, Silvio; Kovařík, Tomáš; Hájek, Jiří; Wink, Márcia Rosângela

doi:10.1016/j.apmt.2023.101875

Cited by 6 publications

(4 citation statements)

References 61 publications

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“…The performed studies concluded that the geopolymer scaffold showed no negative impact on the tested cell line. Furthermore, cells formed a monolayer on its surface, which indicated the biocompatibility of the examined material and its non-cytotoxicity towards the tested cells [35].…”

Section: Bone Regenerationmentioning

confidence: 85%

“…In turn, in the work of de Andrade et al [35], the use of geopolymers in the fabrication of porous composites as scaffolds for bone tissue regeneration was discussed. Here, metakaolin-based geopolymers incorporated with hydroxyapatite were investigated in terms of their porosity, compressive strength and crystallinity.…”

Section: Bone Regenerationmentioning

confidence: 99%

“…In Table 1, the above-presented application of geopolymers for biomedical areas is briefly summarized. [25,[30][31][32][33][34][35][36][37][38][39][40].…”

Section: Dental Implantologymentioning

confidence: 99%

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Geopolymers: Advanced Materials in Medicine, Energy, Anticorrosion and Environmental Protection

Kudłacik-Kramarczyk,

Drabczyk,

Figiela

et al. 2023

Materials

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The initial predictions of the importance of geopolymers primarily assumed use mainly in the construction sector. However, as research progresses, it is becoming clear that these versatile materials demonstrate the ability to greatly exceed their original applications, as characterized in detail in this review article. To the best of our knowledge, there is no literature review concerning geopolymer materials that compiles the diverse applications of these versatile materials. This paper focuses on geopolymer applications beyond the construction industry. The surprising application potential of geopolymers in medicine has become a topic of particular interest. Therefore, considerable attention in this paper is devoted to characterizing the utility of these materials in tissue engineering, dentistry and drug delivery systems. Geopolymers not only have exceptional heat resistance and compressive strength, making them durable and resistant to manipulation (over five times less drug released from the geopolymer carrier compared to the commercial formulation), but also provide a robust solution for extended-release drug delivery systems, especially in opioid formulations. Their chemical stability, porous structure and ability to maintain structure after repeated regeneration processes speak to their potential in water treatment. Geopolymers, which excel in the energy industry as refractory materials due to their resistance to high temperatures and refractory properties, also present potential in thermal insulation and energy storage. It was demonstrated that geopolymer-based systems may even be 35% cheaper than conventional ones and show 70% lower thermal conductivity. In terms of protection against microorganisms, the possibility of modifying geopolymers with antimicrobial additives shows their adaptability, maintaining their effectiveness even under high-temperature conditions. Research into their use as anticorrosion materials is targeting corrosion-resistant coatings, with geopolymers containing graphene oxide showing particularly promising results. The multitude of potential applications for geopolymers in a variety of fields reflects their enormous potential. As research progresses, the scope of their possibilities continues to expand, offering innovative solutions to pressing global challenges.

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Section: Bone Regenerationmentioning

confidence: 85%

Section: Bone Regenerationmentioning

confidence: 99%

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Geopolymers: Advanced Materials in Medicine, Energy, Anticorrosion and Environmental Protection

Kudłacik-Kramarczyk,

Drabczyk,

Figiela

et al. 2023

Materials

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“…There is also an expanding area of potential applications of geopolymers as implant materials and for bone regeneration, as reviewed in the literature. 134 Special attention has received the design of geopolymers with properties suitable for bone tissue engineering, for example, combined with hydroxyapatite and other calcium phosphate ceramics, 135 and for dental restorative materials. 136,137 On the other hand, applications of geopolymers in contact with the human body have also raised concerns, particularly regarding potential toxicity, pH variation effects, and low osteoconductivity.…”

Section: From Construction Materials To High-end Technical Applicationsmentioning

confidence: 99%

Why geopolymers and alkali‐activated materials are key components of a sustainable world: A perspective contribution

Kriven,

Leonelli,

Provis

et al. 2024

J Am Ceram Soc.

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This perspective article delves into the transformative potential of alkali‐activated materials, acid‐activated materials, and geopolymers in mitigating climate change and market challenges. To harness the benefits of these materials, a comprehensive strategy is proposed. This strategy aims to integrate these materials into existing construction regulations, facilitate certification, and promote market access. Emphasizing research and innovation, the article advocates for, increased funding to refine the chemistry and production of these materials, prioritizing low‐cost alternatives and local waste materials. Collaboration between academia and industry is encouraged to expedite technological advances and broaden applications. This article also underscores the need to develop economic and business models emphasizing the long‐term benefits of these materials, including lower life‐cycle costs and reduced environmental impact. Incentivizing adoption through financial mechanisms like tax credits and subsidies is suggested. The strategy also includes scaling up production technology, fostering industrial collaboration for commercial viability, and developing global supply chains. Educational programs for professionals and regulators are recommended to enhance awareness and adoption. Additionally, comprehensive life‐cycle assessments are proposed to demonstrate environmental benefits. The strategy culminates in expanding the applications of these materials beyond construction, fostering international collaboration for knowledge sharing, and thus positioning these materials as essential for sustainable construction and climate change mitigation.

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Introduction

Hasirci,

Hasirci

2024

Fundamentals of Biomaterials

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Hierarchically porous bioceramics based on geopolymer-hydroxyapatite composite as a novel biomaterial: Structure, mechanical properties and biocompatibility evaluation

Cited by 6 publications

References 61 publications

Geopolymers: Advanced Materials in Medicine, Energy, Anticorrosion and Environmental Protection

Geopolymers: Advanced Materials in Medicine, Energy, Anticorrosion and Environmental Protection

Why geopolymers and alkali‐activated materials are key components of a sustainable world: A perspective contribution

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