2015
DOI: 10.1016/j.alit.2015.05.004
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Hierarchy and molecular properties of house dust mite allergens

Abstract: The allergenic load of house dust mite allergy is largely constituted by a few proteins with a hierarchical pattern of allergenicity. The serodominant specificities are the group 1&2 and the group 23 faecal allergens. The collective IgE binding to the group 1&2 allergens can measure unequivocal HDM sensitisation better than HDM extracts although discrepancies have been found in regions with complex acarofauna suggesting a need to investigate the specificity with allergen components. The group 4, 5, 7&21 allerg… Show more

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Cited by 152 publications
(153 citation statements)
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References 105 publications
(126 reference statements)
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“…Scabies mites are closely related phylogenetically to other astigmatid mites including the Dermatophagoides spp. house dust mites that are known to be the sources of at least 33 allergen molecules (Thomas 2015). A search of our scabies genome revealed the presence of genes coding for homologs of 27 of these 33 proteins (Rider et al 2015).…”
Section: Other Proteins Of Interestmentioning
confidence: 99%
“…Scabies mites are closely related phylogenetically to other astigmatid mites including the Dermatophagoides spp. house dust mites that are known to be the sources of at least 33 allergen molecules (Thomas 2015). A search of our scabies genome revealed the presence of genes coding for homologs of 27 of these 33 proteins (Rider et al 2015).…”
Section: Other Proteins Of Interestmentioning
confidence: 99%
“…The protease activity of HDM allergens has been shown to cause barrier dysfunction, to induce the production of proinflammatory cytokines in epithelial cells and keratinocytes, to cleave various molecules, to modulate functions of various cell types, and to induce Th2 responses and IgE production (3)(4)(5)(6)(7)(8)(9)(10). HDM group 1 allergens, Der f 1 and Der p 1, and papain, a papaya fruit-derived occupational allergen, belong to the same family of cysteine proteases, family C1 of clan CA (5,11,12). Protease activity of papain (10,13) and recombinant Der f 1 (rDer f 1) (10) is essential to airway eosinophilia and serum IgE/IgG1 responses induced by inhalation of the protease allergens.…”
mentioning
confidence: 99%
“…Mites are now recognized as a major source of allergens in house dust [5]. Most patients with AD have high levels of specific immunoglobulin E (IgE) to house dust mite (HDM) allergens, and circulating mite-specific T cells are observed in the majority (70%) of mite-sensitive patients with AD [6,7].…”
Section: Introductionmentioning
confidence: 99%