Hierarchy of Sca-1positive and Sca-1negative hematopoietic stem and progenitor cells and their contribution to blood cell production

CLASP2 safeguards hematopoietic stem cell properties during mouse and fish development

“…To determine how CLASP2 might influence the fate of HSCs, we examined important hematopoietic markers, such as SCA-1 and c-Kit, that are known to play a role in differentiation, proliferation, and survival of hematopoietic (stem) cells (Ogawa et al, 1991;Okada et al, 1991;Paral et al, 2018). Flow cytometry analyses of IAHC cells revealed a slight decrease in c-Kit mean fluorescence intensity (MFI) in Clasp2 À/À embryos at E11 (Figure 5A).…”