Hierridin B and 2,4-dimethoxy-6-heptadecyl-phenol, secondary metabolites from the cyanobacterium Phormidium ectocarpi with antiplasmodial activity

Papendorf, Olaf; König, Gabriele M.; Wright, Anthony D.

doi:10.1016/s0031-9422(98)00440-3

Cited by 60 publications

(40 citation statements)

References 11 publications

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“…Tanikolide 1, is an antifungal compound isolated from the lipid extract of Lyngbya majuscula (Singh et al 1999). Whereas, hierridin B, is an antiplasmodial compound obtained from lipophilic extract of Phormidium ectocarpi (Papendorf et al 1998). …”

Section: Lipopolysaccharides (Lps)mentioning

confidence: 99%

Sustainability and cyanobacteria (blue-green algae): facts and challenges

Sharma¹,

et al. 2010

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Cyanobacteria (blue-green algae) are widely distributed Gram-negative oxygenic photosynthetic prokaryotes with a long evolutionary history. They have potential applications such as nutrition (food supplements and fine chemicals), in agriculture (as biofertilizer and in reclamation of saline USAR soils) and in wastewater treatment (production of exopolysaccharides and flocculants). In addition, they also produce wide variety of chemicals not needed for their normal growth (secondary metabolites) which show powerful biological activities such as strong antiviral, antibacterial, antifungal, antimalarial, antitumoral and anti-inflammatory activities useful for therapeutic purposes. In recent years, cyanobacteria have gained interest for producing biofuels (both biomass and H 2 production). Because of their simple growth needs, it is potentially cost-effective to exploit cyanobacteria for the production of recombinant compounds of medicinal and commercial value. Recent advances in culture, screening and genetic engineering techniques have opened new ways to exploit the potential of cyanobacteria. This review analyses the sustainability of cyanobacteria to solve global problems such as food, energy and environmental degradation. It emphasizes the need to adopt multidisciplinary approaches and a multi-product production (biorefinery) strategy to harness the maximum benefit of cyanobacteria.

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Section: Lipopolysaccharides (Lps)mentioning

confidence: 99%

Sustainability and cyanobacteria (blue-green algae): facts and challenges

Sharma¹,

et al. 2010

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“…Some metabolites such as cyanotoxins are reported to have toxic effects, but they can be exploited for their allelochemical nature and can be introduced in agricultural fields as pesticides i.e., algicides, fungicides, weedicides, and herbicides. Apart from the toxic metabolite production, they are also enriched with several pharmacologically active compounds that have antibacterial (Volka and Furkert, 2006; Malathi et al, 2014), anticancerous (Gerwick et al, 1994; Mukund and Sivasubramanian, 2014; Semary and Fouda, 2015), antifungal (Rath and Priyadarshani, 2013; Shaieb et al, 2014), antiplasmodial (Papendorf et al, 1998), antiviral (Patterson et al, 1994; Abdo et al, 2012), and immunosuppressive (Koehn et al, 1992; Vijayakumar and Menakha, 2015) activities, which have aggravated interest in cyanobacterial and algal secondary metabolites. Thus, due to high pharmaceutical values, a new perspective of utilizing cyanobacteria and algae in the field of medicine has risen.…”

Section: Introductionmentioning

confidence: 99%

Uncovering Potential Applications of Cyanobacteria and Algal Metabolites in Biology, Agriculture and Medicine: Current Status and Future Prospects

et al. 2017

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Cyanobacteria and algae having complex photosynthetic systems can channelize absorbed solar energy into other forms of energy for production of food and metabolites. In addition, they are promising biocatalysts and can be used in the field of “white biotechnology” for enhancing the sustainable production of food, metabolites, and green energy sources such as biodiesel. In this review, an endeavor has been made to uncover the significance of various metabolites like phenolics, phytoene/terpenoids, phytols, sterols, free fatty acids, photoprotective compounds (MAAs, scytonemin, carotenoids, polysaccharides, halogenated compounds, etc.), phytohormones, cyanotoxins, biocides (algaecides, herbicides, and insecticides) etc. Apart from this, the importance of these metabolites as antibiotics, immunosuppressant, anticancer, antiviral, anti-inflammatory agent has also been discussed. Metabolites obtained from cyanobacteria and algae have several biotechnological, industrial, pharmaceutical, and cosmetic uses which have also been discussed in this review along with the emerging technology of their harvesting for enhancing the production of compounds like bioethanol, biofuel etc. at commercial level. In later sections, we have discussed genetically modified organisms and metabolite production from them. We have also briefly discussed the concept of bioprocessing highlighting the functioning of companies engaged in metabolites production as well as their cost effectiveness and challenges that are being addressed by these companies.

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“…Os primeiros estudos foram realizados com cianobactérias marinhas na década de 1970, por Richard E. Moore, na Universidade do Havaí, mostrando que as cianobactérias são fontes ricas de metabólitos secundários (CARDELLINA & MOORE, 2010), representando um inexplorado recurso biológico para uma gama de diversidade desses metabólitos (ISHIBASHI et al, 1986). Estes metabólitos incluem substâncias antibacteriana, antifúngica, antiviral, anticâncer, antiplasmódica, algicida, agentes imunossupressores e anti-inflamatório (KOEHN et al, 1992;GERWICK et al, 1994;PATTERSON et al, 1994;PAPKE et al, 1997;KAJIYAMA et al, 1998;PAPENDORF, 1998;JAKI et al, 2000;VILLA & GERWICK, 2010) Fonte: ABED et. al.…”

Section: Compostos Bioativos Com Propriedades Farmacológicasunclassified

Cianobactérias: uma revisão sobre potencial nutricional e alguns aspectos biotecnológicos

Oliveira

Campos-Galvão

et al. 2013

BBR

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SUMMARYCyanobacteria are used in human nutrition since ancient times, with very high biotechnological, therapeutical and nutrition potential. The aim of this article was to review the main nutritional aspects related to the cyanobacteria that justify its introduction in food. The studies analyzed dealt especially with the cyanobacterium Spirulina and highlighted the high content of assential amino acids and lipids, vitamins and minerals, and antioxidants. It is concluded that the cyanobacterial represent an excellent nutritional supplement and a potential source for use in the prevention and treatment of various diseases. It is suggested that more microalgae should be surveyed in order to expand the knowledge and application possibilities. Keywords

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Hierridin B and 2,4-dimethoxy-6-heptadecyl-phenol, secondary metabolites from the cyanobacterium Phormidium ectocarpi with antiplasmodial activity

Cited by 60 publications

References 11 publications

Sustainability and cyanobacteria (blue-green algae): facts and challenges

Sustainability and cyanobacteria (blue-green algae): facts and challenges

Uncovering Potential Applications of Cyanobacteria and Algal Metabolites in Biology, Agriculture and Medicine: Current Status and Future Prospects

Cianobactérias: uma revisão sobre potencial nutricional e alguns aspectos biotecnológicos

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