HIF-1, Metabolism, and Diabetes in the Embryonic and Adult Heart

Čerychová, Radka; Pavlínková, Gabriela

doi:10.3389/fendo.2018.00460

Cited by 110 publications

(75 citation statements)

References 145 publications

(163 reference statements)

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“…Some studies showed that cells cultured in high glucose concentration medium present with decreased levels of HIF-1α. This led to a consensus that hyperglycemia was responsible for decreased HIF-1α protein levels (Xiao et al, 2013;Cerychova and Pavlinkova, 2018). Investigation of the effect of certain glucose concentrations on HIF-1α expression in human dermal fibroblasts (HDF) at normoxia and hypoxia showed that HIF-1α expression depends on glucose concentration only in hypoxia.…”

Section: Gapdhmentioning

confidence: 99%

HIF-1α as a Mediator of Insulin Resistance, T2DM, and Its Complications: Potential Links With Obstructive Sleep Apnea

et al. 2020

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Obstructive sleep apnea syndrome (OSA) is described as an independent risk factor for the onset and progression of type 2 diabetes (T2DM), as well as for insulin resistance (IR). The mechanisms underlying these processes remain unclear. One of the proposed molecular mechanism is based on the oxygen-sensitive α-subunit of hypoxia-inducible factor 1 (HIF-1α)-a key regulator of oxygen metabolism. The concept that stabilization of HIF-1α may influence T2DM and IR is supported by cell and animal models. Cell culture studies revealed that both glucose uptake and glycolysis are regulated by HIF-1α. Furthermore, animal models indicated that increased fasting glucose may be caused by a single night with intermittent hypoxia. Moreover, in these models, hypoxia time was correlated with IR. Mice models revealed that inhibition of HIF-1α protein may downregulate fasting blood glucose and plasma insulin level. Administration of superoxide dismutase mimetic resulted in inhibition of HIF-1α protein, catecholamines, and chronic intermittent hypoxia-induced hypertension in a mice model. The hypothesis that hypoxia is an independent risk factor for IR is strengthened by experimentally confirmed improvement of insulin sensitivity among OSA patients treated with the continuous positive airway pressure. Furthermore, recent studies suggest that HIF-1α protein concentration is increased in individuals with OSA. In this literature review, we summarize the current knowledge about HIF-1α in OSA in relation to the possible pathways in which they contribute to metabolic disorders.

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Section: Gapdhmentioning

confidence: 99%

HIF-1α as a Mediator of Insulin Resistance, T2DM, and Its Complications: Potential Links With Obstructive Sleep Apnea

et al. 2020

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“…HIF-2α and HIF-3α are found in vertebrates and are expressed in a cell-type specific manner (Semenza, 2020). HIF-1α has been shown to be essential to embryonic development (Cerychova and Pavlinkova, 2018), and HIF-2α is noted for regulation of EPO transcription, to produce erythropoietin (EPO) protein postnatally in the kidney (Gruber et al, 2007;Haase, 2013). While these transcription factors regulate thousands of genes, the roles of HIF-3α remain to be extensively characterized (Yang S. L. et al, 2015;Duan, 2016).…”

Section: Hypoxia Signaling and The Hif Pathwaymentioning

confidence: 99%

Cross-Species Insights Into Genomic Adaptations to Hypoxia

et al. 2020

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Over millions of years, vertebrate species populated vast environments spanning the globe. Among the most challenging habitats encountered were those with limited availability of oxygen, yet many animal and human populations inhabit and perform life cycle functions and/or daily activities in varying degrees of hypoxia today. Of particular interest are species that inhabit high-altitude niches, which experience chronic hypobaric hypoxia throughout their lives. Physiological and molecular aspects of adaptation to hypoxia have long been the focus of high-altitude populations and, within the past decade, genomic information has become increasingly accessible. These data provide an opportunity to search for common genetic signatures of selection across uniquely informative populations and thereby augment our understanding of the mechanisms underlying adaptations to hypoxia. In this review, we synthesize the available genomic findings across hypoxia-tolerant species to provide a comprehensive view of putatively hypoxia-adaptive genes and pathways. In many cases, adaptive signatures across species converge on the same genetic pathways or on genes themselves [i.e., the hypoxia inducible factor (HIF) pathway). However, specific variants thought to underlie function are distinct between species and populations, and, in most cases, the precise functional role of these genomic differences remains unknown. Efforts to standardize these findings and explore relationships between genotype and phenotype will provide important clues into the evolutionary and mechanistic bases of physiological adaptations to environmental hypoxia.

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“…Growing interconversion of lactate and pyruvate is greatly increased and upregulates CNDP1 which is necessary for carnosine uptake [55,56]. The inhibited fatty acid oxidation concatenated by the hypoxia condition inducing hypoxia-inducible factor-1 (HIF-1) which triggers glycolysis in T2DM and GDM patients [57]. In turn, oxidative damage caused by lactate interconversion evokes the rising up-regulation of CRP as a protective response to defense against oxidative stress and subsequent chronic inflammation condition.…”

Section: Discussionmentioning

confidence: 99%

Association of Proteins Modulating Immune Response and Insulin Clearance during Gestation with Antenatal Complications in Patients with Gestational or Type 2 Diabetes Mellitus

Kopylov

Kaysheva

Папышева

et al. 2020

Cells

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Background: The purpose of the study is to establish and quantitatively assess protein markers and their combination in association with insulin uptake that may be have value for early prospective recognition of diabetic fetopathy (DF) as a complication in patients with diabetes mellitus during gestation. Methods: Proteomic surveying and accurate quantitative measurement of selected proteins from plasma samples collected from the patients with gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) who gave birth of either healthy or affected by maternal diabetes newborns was performed using mass spectrometry. Results: We determined and quantitatively measured several proteins, including CRP, CEACAM1, CNDP1 and Ig-family that were significantly differed in patients that gave birth of newborns with signs of DF. We found that patients with newborns associated with DF are characterized by significantly decreased CEACAM1 (113.18 ± 16.23 ng/mL and 81.09 ± 10.54 ng/mL in GDM and T2DM, p < 0.005) in contrast to control group (515.6 ± 72.14 ng/mL, p < 0.005). On the contrary, the concentration of CNDP1 was increased in DF-associated groups and attained 49.3 ± 5.18 ng/mL and 37.7 ± 3.34 ng/mL (p < 0.005) in GDM and T2DM groups, respectively. Among other proteins, dramatically decreased concentration of IgG4 and IgA2 subclasses of immunoglobulins were noticed. Conclusion: The combination of the measured markers may assist (AUC = 0.893 (CI 95%, 0.785-0.980) in establishing the clinical finding of the developing DF especially in patients with GDM who are at the highest risk of chronic insulin resistance.Cells 2020, 9, 1032 2 of 22 mellitus, type 2 diabetes mellitus (T2DM) or gestational diabetes mellitus (GDM) suffered by pregnant women. Diabetic fetopathy is the cause of premature birth, chronic hypoxia, respiratory depression, asphyxia of the fetus at birth, accompanied by various metabolic disorders, and can also be the cause of newborns death [1][2][3]. This is one of the most common forms of obstetric complications and perinatal losses evoked from hyperglycemia manifested in a disturbance of glucose tolerance and occurred or was first recognized during pregnancy [4]. It is also possible that the disturbance of carbohydrate metabolism could precede pregnancy but has not been previously detected [5,6]. During pregnancy, hyperglycemia is induced by a gradually increased insulin resistance due to both placental hormones and the mother's hormones (prolactin, estrogen and cortisol). The growing concentration of these hormones is compensated by a decrease in the clearance of endogenously produced insulin [2,5].According to the WHO data for 2016, up to 25% of pregnant women are at risk of hyperglycemia during pregnancy [7]. An overwhelming majority (from 75% to 90%) of elevated blood glucose levels during pregnancy emerges from the already progressing GDM [8,9]. Statistics of the IDF for 2017 demonstrate up to 204 million women aged between 20 to 79 years live with different types of diabetes, while up to 21.3 m...

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HIF-1, Metabolism, and Diabetes in the Embryonic and Adult Heart

Cited by 110 publications

References 145 publications

HIF-1α as a Mediator of Insulin Resistance, T2DM, and Its Complications: Potential Links With Obstructive Sleep Apnea

HIF-1α as a Mediator of Insulin Resistance, T2DM, and Its Complications: Potential Links With Obstructive Sleep Apnea

Cross-Species Insights Into Genomic Adaptations to Hypoxia

Association of Proteins Modulating Immune Response and Insulin Clearance during Gestation with Antenatal Complications in Patients with Gestational or Type 2 Diabetes Mellitus

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