HIF-1ɑ-regulated miR-1275 maintains stem cell-like phenotypes and promotes the progression of LUAD by simultaneously activating Wnt/β-catenin and Notch signaling

Jiang, Neng; Zou, Chang; Zhu, Ying; Luo, Yi; Chen, Lili; Lei, Yiyan; Tang, Kejing; Sun, Yu; Zhang, Wenhui; Li, Shuhua; He, Qi; Zhou, Jianwen; Chen, Yangshan; Luo, Jiping; Jiang, Wenting; Ke, Zunfu

doi:10.7150/thno.41120

Cited by 106 publications

(82 citation statements)

References 69 publications

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“…The Wnt/β-catenin signaling pathway is speculated to serve a key role in the self-renewal capacity of CSCs and is activated in several types of human malignancies including LUAD ( 37 ). Therefore, the present study hypothesized that upregulated miR-140-3p expression may repress the Wnt/β-catenin signaling, thereby attenuating the stem cell-like properties and cisplatin resistance in LUAD.…”

Section: Resultsmentioning

confidence: 99%

miR‑140‑3p enhances cisplatin sensitivity and attenuates stem cell‑like properties through repressing Wnt/β‑catenin signaling in lung adenocarcinoma cells

Wang

Pan

et al. 2020

Exp Ther Med

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Lung adenocarcinoma (LUAD) is the most predominant subtype of non-small cell lung cancer (NSCLC) that is experiencing the fastest growth rate in incidence. Chemoresistance and the presence of cancer stem cells are considered to be the main obstacles preventing the successful treatment of patients with NSCLC, the molecular mechanism of which remains poorly understood. The present study aimed to investigate the effects of microRNA (miR)-140-3p on cisplatin sensitivity and stem cell-like properties of LUAD cells. Analysis of publicly available data demonstrated that miR-140-3p expression was downregulated in LUAD, and positively associated with the overall survival rate of patients. In addition, transfection with the miR-140-3p mimic reduced LUAD cell viability and induced apoptosis following treatment with cisplatin whilst decreasing stem cell-like properties. miR-140-3p overexpression was also found to attenuate cisplatin resistance and reduce stem cell-like properties in LUAD cells by suppressing Wnt/β-catenin signaling, all of which were reversed by the overexpression of β-catenin. Taken together, results of the present study suggest miR-140-3p to be an effective therapeutic strategy for patients with LUAD.

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Section: Resultsmentioning

confidence: 99%

miR‑140‑3p enhances cisplatin sensitivity and attenuates stem cell‑like properties through repressing Wnt/β‑catenin signaling in lung adenocarcinoma cells

Wang

Pan

et al. 2020

Exp Ther Med

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“…We used a webserver “gene expression profiling interactive analysis (GEPIA) 2” [ 22 ] ( http://gepia2.cancer-pku.cn/#index ) which contains expression profiling of TCGA-LUAD data with matched TCGA and GTEx [ 23 ] normal tissues. The lung adenocarcinoma gene expression profiling datasets were downloaded by searching the NCBI gene expression omnibus (GEO) database ( https://www.ncbi.nlm.nih.gov/geo/ ) using the keywords “lung adenocarcinoma”, and “lung cancer”, and identified six gene expression datasets: GSE40791 [ 24 ], GSE43458 [ 25 ], GSE19804 [ 26 , 27 ], GSE136043 [ 28 ], GSE118370 [ 29 ], and GSE13213 [ 30 ]. Besides, the lung adenocarcinoma TCGA-LUAD cohort was downloaded from the TCGA data portal ( https://portal.gdc.cancer.gov/ ).…”

Section: Methodsmentioning

confidence: 99%

Expression of SARS-COV-2 cell receptor gene ACE2 is associated with immunosuppression and metabolic reprogramming in lung adenocarcinoma based on bioinformatics analyses of gene expression profiles

Uddin

Akter²,

et al. 2021

Chemico-Biological Interactions

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“…In addition, miR-600, miR-128-3p, miR-302c, and miR-320 also weaken stemness by targeting the mediators of Wnt/β-catenin signaling SCD1, NEK2, CARF, and CTNNB1 , respectively [ [39] , [40] , [41] , [42] ]. Hypoxia is also a key promoter of CSCs, and miR-1275 is regulated by HIF-1α and maintains stemness by targeting multiple genes in the Wnt signaling pathway, such as DKK3 , SFRP1 , GSK3β , and RUNX3 [ 43 ]. Therefore, various miRNAs and competing endogenous RNAs (ceRNAs) are involved in the regulation of Wnt/β-catenin signaling.…”

Section: Involvement Of Mirnas In Maintaining Cscsmentioning

confidence: 99%

miRNA signaling networks in cancer stem cells

Yoshida

Yamamoto²,

Ochiya

2021

Regenerative Therapy

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Cancer stem cells (CSCs) are a small cell subpopulation in many cancer types and are involved in various processes of tumor progression, such as initiation, metastasis and recurrence. The distinguished features of CSCs include a variety of biological properties, including self-renewal, multidifferentiation, stemness marker expression, and resistance to chemotherapy and radiotherapy. Despite their great potential of clinical importance, the CSC signaling pathways are not well understood at the molecular level. MicroRNAs (miRNAs) are a class of endogenous noncoding RNAs that play an important role in the regulation of several cellular, physiological, and developmental processes. Aberrant miRNA expression is associated with many human diseases, including cancer. miRNAs have been implicated in the regulation of CSC properties; therefore, a better understanding of miRNA-induced modulation of CSC gene expression could aid in the identification of promising biomarkers and therapeutic targets. In the present review, we summarize the major findings of the impacts of miRNAs on CSC signaling networks; we then discuss the recent advances that have improved our understanding of CSC regulation by miRNA-mediated signaling networks and that may lead to the development of miRNA therapeutics specifically targeting CSCs.

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HIF-1ɑ-regulated miR-1275 maintains stem cell-like phenotypes and promotes the progression of LUAD by simultaneously activating Wnt/β-catenin and Notch signaling

Cited by 106 publications

References 69 publications

miR‑140‑3p enhances cisplatin sensitivity and attenuates stem cell‑like properties through repressing Wnt/β‑catenin signaling in lung adenocarcinoma cells

miR‑140‑3p enhances cisplatin sensitivity and attenuates stem cell‑like properties through repressing Wnt/β‑catenin signaling in lung adenocarcinoma cells

Expression of SARS-COV-2 cell receptor gene ACE2 is associated with immunosuppression and metabolic reprogramming in lung adenocarcinoma based on bioinformatics analyses of gene expression profiles

miRNA signaling networks in cancer stem cells

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