HIF-3α-Induced miR-630 Expression Promotes Cancer Hallmarks in Cervical Cancer Cells by Forming a Positive Feedback Loop

Gao, Qiaohui; Ren, Zhenghua; Jiao, Shengyuan; Guo, Juan; Miao, Xiangshui; Wang, Jin; Liu, Junye

doi:10.1155/2022/5262963

Cited by 6 publications

(9 citation statements)

References 34 publications

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“…The increased expression of HIF-3α could promote the expression of miR-603, and the high expression of miR-630 could lead to the apoptosis of HeLa cells induced by radiotherapy, while the silencing of miR-630 could accelerate the apoptosis induced by radiotherapy. These results indicate that miR-630 has an anti-radiation function, and the high expression of miR-630 can also promote the expression of HIF-3α, and both have a positive regulatory ring effect ( 70 ).…”

Section: Possible Mechanism Of Resistance To Radiotherapy For Cervica...mentioning

confidence: 93%

Review of possible mechanisms of radiotherapy resistance in cervical cancer

Zhang,

Wang,

et al. 2023

Front. Oncol.

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Radiotherapy is one of the main treatments for cervical cancer. Early cervical cancer is usually considered postoperative radiotherapy alone. Radiotherapy combined with cisplatin is the standard treatment for locally advanced cervical cancer (LACC), but sometimes the disease will relapse within a short time after the end of treatment. Tumor recurrence is usually related to the inherent radiation resistance of the tumor, mainly involving cell proliferation, apoptosis, DNA repair, tumor microenvironment, tumor metabolism, and stem cells. In the past few decades, the mechanism of radiotherapy resistance of cervical cancer has been extensively studied, but due to its complex process, the specific mechanism of radiotherapy resistance of cervical cancer is still not fully understood. In this review, we discuss the current status of radiotherapy resistance in cervical cancer and the possible mechanisms of radiotherapy resistance, and provide favorable therapeutic targets for improving radiotherapy sensitivity. In conclusion, this article describes the importance of understanding the pathway and target of radioresistance for cervical cancer to promote the development of effective radiotherapy sensitizers.

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Section: Possible Mechanism Of Resistance To Radiotherapy For Cervica...mentioning

confidence: 93%

Review of possible mechanisms of radiotherapy resistance in cervical cancer

Zhang,

Wang,

et al. 2023

Front. Oncol.

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“…One of the factors affecting the transcription of genes responsible for cell adaptation to hypoxia is the hypoxia-inducible factor (HIF). The family of HIF factors includes HIF-1α, HIF-2α, and HIF-3α [ 115 , 116 ]. Gao et al [ 115 ] showed that the increased expression of HIF3α caused by hypoxia increases the expression of the miR-630, and at the same time the increased expression of miR-630 induces overexpression of HIF-3α.…”

Section: Role Of Mirnas In Cervical Cancermentioning

confidence: 99%

“…The family of HIF factors includes HIF-1α, HIF-2α, and HIF-3α [ 115 , 116 ]. Gao et al [ 115 ] showed that the increased expression of HIF3α caused by hypoxia increases the expression of the miR-630, and at the same time the increased expression of miR-630 induces overexpression of HIF-3α. Thus, a feedback loop between miR-630 and HIF-3α has been demonstrated.…”

Section: Role Of Mirnas In Cervical Cancermentioning

confidence: 99%

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MicroRNAs as Potential Biomarkers in Gynecological Cancers

2023

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MicroRNAs are non-coding transcripts that, thanks to the ability to regulate the mRNA of target genes, can affect the expression of genes encoding tumor suppressors and oncogenes. They can control many important cellular processes, including apoptosis, differentiation, growth, division, and metabolism. Therefore, miRNAs play an important role in the development of many cancers, including gynecological cancers. Ovarian cancer, endometrial cancer, cervical cancer, and vulvar cancer are the most common cancers in women and are a frequent cause of death. The heterogeneity of the pathogenesis of these gynecological diseases makes the diagnostic process a significant obstacle for modern medicine. To date, many studies have been carried out, in which particular attention has been paid to the molecular pathomechanism of these diseases, with particular emphasis on miRNAs. To date, the changed profile of many miRNAs, which influenced the promotion of proliferation, migration, invasion processes and the simultaneous inhibition of programmed cell death, has been proven many times. Detailed understanding of the molecular effects of miRNAs in the above-mentioned gynecological cancers will enable the development of potential predictive and prognostic biomarkers, as well as the optimization of the diagnostic process.

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“…It is overexpressed in multiple types of cancers, including osteosarcoma, ovarian, colorectal, bladder, hepatic, gastric, and renal cancers [12][13][14][15][16][17][18][19]. In these contexts, miR-630 functions as an oncomiR by promoting cell proliferation, migration, invasion, and increasing chemoresistance or radioresistance [20][21][22][23][24][25][26]. Conversely, miR-630 has also been reported as a tumor suppressor, as shown by the downregulation in tumors and inhibiting cancer aggressiveness in several types of cancer, such as esophageal, breast, glioma, and lung [27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

MiR-630 Promotes Radioresistance by Induction of Anti-Apoptotic Effect via Nrf2–GPX2 Molecular Axis in Head–Neck Cancer

You,

Cheng,

Shen

et al. 2023

Cells

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Head and neck cancer (HNC) ranks among the top ten prevalent cancers worldwide. Radiotherapy stands as a pivotal treatment component for HNC; however, radioresistance in cancerous cells often leads to local recurrence, becoming a substantial factor in treatment failure. MicroRNAs (miRNAs) are compact, non-coding RNAs that regulate gene expression by targeting mRNAs to inhibit protein translation. Although several studies have indicated that the dysregulation of miRNAs is intricately linked with malignant transformation, understanding this molecular family’s role in radioresistance remains limited. This study determined the role of miR-630 in regulating radiosensitivity in HNC. We discovered that miR-630 functions as an oncomiR, marked by its overexpression in HNC patients, correlating with a poorer prognosis. We further delineated the malignant function of miR-630 in HNC cells. While it had a minimal impact on cell growth, the miR-630 contributed to radioresistance in HNC cells. This result was supported by decreased cellular apoptosis and caspase enzyme activities. Moreover, miR-630 overexpression mitigated irradiation-induced DNA damage, evidenced by the reduced levels of the γ-H2AX histone protein, a marker for double-strand DNA breaks. Mechanistically, the overexpression of miR-630 decreased the cellular ROS levels and initiated Nrf2 transcriptional activity, resulting in the upregulation of the antioxidant enzyme GPX2. Thus, this study elucidates that miR-630 augments radioresistance by inducing an anti-apoptotic effect via the Nrf2–GPX2 molecular axis in HNC. The modulation of miR-630 may serve as a novel radiosensitizing target for HNC.

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HIF-3α-Induced miR-630 Expression Promotes Cancer Hallmarks in Cervical Cancer Cells by Forming a Positive Feedback Loop

Cited by 6 publications

References 34 publications

Review of possible mechanisms of radiotherapy resistance in cervical cancer

Review of possible mechanisms of radiotherapy resistance in cervical cancer

MicroRNAs as Potential Biomarkers in Gynecological Cancers

MiR-630 Promotes Radioresistance by Induction of Anti-Apoptotic Effect via Nrf2–GPX2 Molecular Axis in Head–Neck Cancer

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