HIF has Biff – Crosstalk between HIF1a and the family of bHLH/PAS proteins

Button, Emily L.; Bersten, David C.; Whitelaw, Murray L.

doi:10.1016/j.yexcr.2017.03.055

Cited by 27 publications

(30 citation statements)

References 53 publications

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“…Such stressors can have serious consequences for aquatic organisms, and especially fish populations. The actions of these stressors may be through some common pathways, such as the aryl hydrocarbon receptor originally implicated in hydrocarbon-exposure effects (Incardona, 2017), but now also implicated in hypoxia responses (Button et al, 2017;Nie et al, 2001). Exposure to crude oil and the basic cellular and molecular responses it evokes thus represents a contemporary and important environmental challenge.…”

Section: Introductionmentioning

confidence: 99%

Parental stressor exposure simultaneously conveys both adaptive and maladaptive larval phenotypes through epigenetic inheritance in the zebrafish (Danio rerio)

Bautista

Burggren

2019

Journal of Experimental Biology

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Genomic modifications occur slowly across generations, whereas short-term epigenetic inheritance of adaptive phenotypes may be immediately beneficial to large numbers of individuals, acting as a bridge for survival when adverse environments occur. In the present study, crude oil was used as an example of an environmental stressor. Adult zebrafish (P 0) were dietarily exposed for 3 weeks to no, low, medium or high concentrations of crude oil. The F 1 offspring obtained from the P 0 groups were then assessed for transgenerational epigenetic transfer of oil-induced phenotypes. The exposure did not alter body length, body and organ mass or condition factor in the P 0 groups. However, the P 0 fecundity of both sexes decreased in proportion to the amount of oil fed. The F 1 larvae from each P 0 were then exposed from 3 hpf to 5 dpf to oil in their ambient water. Remarkably, F 1 larvae derived from oil-exposed parents, when reared in oiled water, showed a 30% enhanced survival compared with controls (P<0.001). Unexpectedly, from day 3 to 5 of exposure, F 1 larvae from oil-exposed parents showed poorer survival in clean water (up to 55% decreased survival). Additionally, parental oil exposure induced bradycardia (presumably maladaptive) in F 1 larvae in both clean and oiled water. We conclude that epigenetic transgenerational inheritance can lead to an immediate and simultaneous inheritance of both beneficial and maladaptive traits in a large proportion of the F 1 larvae. The adaptive responses may help fish populations survive when facing transient environmental stressors.

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Section: Introductionmentioning

confidence: 99%

Parental stressor exposure simultaneously conveys both adaptive and maladaptive larval phenotypes through epigenetic inheritance in the zebrafish (Danio rerio)

Bautista

Burggren

2019

Journal of Experimental Biology

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“…Both alpha and beta subunits contain Per‐ARNT‐Sim (PAS) domains, involved with heterodimerization, and bHLH domain at N‐terminus, which is DNA‐binding domain. Whereas, C‐terminus is used for the recruitment of transcriptional coregulatory proteins (Button, Bersten, & Whitelaw, ). However, under physiological oxygen level this transactivation domain is hydroxylated on Asp 803 by factor inhibiting HIF (FIH), which prevents interaction between HIF and coactivators (Koivunen, Hirsila, Gunzler, Kivirikko, & Myllyharju, ).…”

Section: Hif Pathwaymentioning

confidence: 99%

The insights into molecular pathways of hypoxia‐inducible factor in the brain

Ostrowski

Zhang

2018

J of Neuroscience Research

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The objectives of this present work were to review recent developments on the role of hypoxia‐inducible factor (HIF) in the survival of cells under normoxic versus hypoxic and inflammatory brain conditions. The dual nature of HIF effects appears well established, based on the accumulated evidence of HIF playing both the role of adaptive factor and mediator of cell demise. Cellular HIF responses depend on pathophysiological conditions, developmental phase, comorbidities, and administered medications. In addition, HIF‐1α and HIF‐2α actions may vary in the same tissues. The multiple roles of HIF in stem cells are emerging. HIF not only regulates expression of target genes and thereby influences resultant protein levels but also contributes to epigenetic changes that may reciprocally provide feedback regulations loops. These HIF‐dependent alterations in neurological diseases and its responses to treatments in vivo need to be examined alongside with a functional status of subjects involved in such studies. The knowledge of HIF pathways might be helpful in devising HIF‐mimetics and modulating drugs, acting on the molecular level to improve clinical outcomes, as exemplified here by clinical and experimental data of selected brain diseases, occasionally corroborated by the data from disorders of other organs. Because of complex role of HIF in brain injuries, prospective therapeutic interventions need to differentially target HIF responses depending on their roles in the molecular mechanisms of neurologic diseases.

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“…The Hypoxia Inducible Factors (HIFs) proteins are transcription factors that play a key role in the homeostasis of oxygen in animals, Rytkonen & Storz (2011). HIFs proteins are basic Helix-Loop-Helix–PER–ARNT–SIM (bHLH–PAS) proteins distinguish by being both ubiquitously expressed and signal-regulated or constitutively active and tissue specific, Button et al (2017). HIFs proteins form heterodimeric complexes that are composed of alpha O 2 -labile subunit, either HIF1A, EPAS1 (HIF2A α) or HIF3A and one stable β-subunit HIF1β also known as Aryl hydrocarbon receptor nuclear translocator (ARNT).…”

Section: Introductionmentioning

confidence: 99%

“…HIFs proteins form heterodimeric complexes that are composed of alpha O 2 -labile subunit, either HIF1A, EPAS1 (HIF2A α) or HIF3A and one stable β-subunit HIF1β also known as Aryl hydrocarbon receptor nuclear translocator (ARNT). In normoxia conditions in presence of O 2 , the HIFA subunits are modified by the HIF-specific prolyl-hydroxylases (PHD), causing proteasomal degradation mediated in part by the von Hippel-Lindau suppressor protein (VHL), Button et al (2017), Fribourgh & Partch (2017).…”

Section: Introductionmentioning

confidence: 99%

A Key For Hypoxia Genetic Adaptation In Alpaca Could Be A HIF1A Truncated bHLH Protein Domain

Figueroa

2018

Preprint

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2 Animals exposed to hypoxia, triggers a physiological response via Hypoxia Inducible Factors (HIF1). In this study, we have evidenced the existence of genetic events that caused the loss of most of the bHLH domain in HIF1A proteins borne by Alpaca and other members of the Cetartiodactyla superorder. In these truncate domains, some stop codons are found at identical nucleotide positions in both, Artiodactyls and Cetaceans, indicating that mutations originating the truncated domains occurs before their divergence about 55 million years ago. The relevance of this findings for adaptation of Alpacas to hypoxia of high altitude conditions are discussed.

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HIF has Biff – Crosstalk between HIF1a and the family of bHLH/PAS proteins

Cited by 27 publications

References 53 publications

Parental stressor exposure simultaneously conveys both adaptive and maladaptive larval phenotypes through epigenetic inheritance in the zebrafish (Danio rerio)

Parental stressor exposure simultaneously conveys both adaptive and maladaptive larval phenotypes through epigenetic inheritance in the zebrafish (Danio rerio)

The insights into molecular pathways of hypoxia‐inducible factor in the brain

A Key For Hypoxia Genetic Adaptation In Alpaca Could Be A HIF1A Truncated bHLH Protein Domain

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