Hif1α-dependent mitochondrial acute O2 sensing and signaling to myocyte Ca2+ channels mediate arterial hypoxic vasodilation
Alejandro Moreno-Domínguez,
Olalla Colinas,
Ignacio Arias-Mayenco
et al.
Abstract:Vasodilation in response to low oxygen (O
2
) tension (hypoxic vasodilation) is an essential homeostatic response of systemic arteries that facilitates O
2
supply to tissues according to demand. However, how blood vessels react to O
2
deficiency is not well understood. A common belief is that arterial myocytes are O
2
-sensitive. Supporting this concept, it has been shown that the activity of myocyte L-type Ca
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