2022
DOI: 10.7150/jca.54402
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HIF1α/HIF2α induces glioma cell dedifferentiation into cancer stem cells through Sox2 under hypoxic conditions

Abstract: Objective: Our previous study showed that glioma stem-like cells could be induced to undergo dedifferentiation under hypoxic conditions, but the mechanism requires further study. HIF1α and HIF2α are the main molecules involved in the response to hypoxia, and Sox2, as a retroelement, plays an important role in the formation of induced pluripotent stem cells, especially in hypoxic microenvironments. Therefore, we performed a series of experiments to verify whether HIF1α, HIF2α and Sox2 regulated glioma cell dedi… Show more

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Cited by 22 publications
(15 citation statements)
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“…The experiment conducted in 2021 proves that differentiated glioma cells with high expression of CD15 in conditions of hypoxia undergo dedifferentiation into cancer stem cells. This study shows that CD15 can be a potential marker of malignant glioma progression [95]. TNF-α, IL-4, IL 17, IL-10,…”
Section: Experimental Medicine Involving Cd15mentioning
confidence: 67%
“…The experiment conducted in 2021 proves that differentiated glioma cells with high expression of CD15 in conditions of hypoxia undergo dedifferentiation into cancer stem cells. This study shows that CD15 can be a potential marker of malignant glioma progression [95]. TNF-α, IL-4, IL 17, IL-10,…”
Section: Experimental Medicine Involving Cd15mentioning
confidence: 67%
“…An experiment conducted in 2021 proved that differentiated glioma cells with high expression of CD15 in conditions of hypoxia undergo dedifferentiation into cancer stem cells. This study shows that CD15 can be a potential marker of malignant glioma progression [71].…”
Section: Gliomasmentioning
confidence: 67%
“…Conversely, silencing HIF1α abolishes the self‐renewal capacity of GSCs and results in reduced tumorigenic potential in vivo 150 . HIF1α/HIF2α induce the dedifferentiation of glioma cells into CSCs through SOX2 under hypoxic conditions, thereby promoting chemoresistance of glioma cells 151 . Other evidence also supports that differentiated GBM cells undergo dedifferentiation under hypoxic conditions to generate GSCs 152 .…”
Section: Effects Of the Tumor Microenvironment In Brain Tumormentioning
confidence: 96%