High (130 Hz)- and mid (60 Hz)-frequency deep brain stimulation in the subthalamic nucleus differentially modulate response inhibition: A preliminary combined EEG and eye tracking study

Waldthaler, Josefine; Sperlich, Alexander; König, Aylin; Stüssel, Charlotte; Bremmer, Frank; Timmermann, Lars; Pedrosa, David J.

doi:10.1016/j.nicl.2023.103314

Cited by 3 publications

(2 citation statements)

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“…Patients had higher inference costs for cognitive and affective reasoning than the physical condition. Inference appears to be slower in patients with DBS ON compared to DBS OFF in the cognitive Yoni task because of high‐frequency stimulation promoting voluntary actions at the expense of reflexive responses 63,64 . No significant group‐level difference between DBS ON and OFF sessions is expected, considering the large individual variability in stimulation locations and parameters among patients.…”

Section: Discussionmentioning

confidence: 99%

“…Inference appears to be slower in patients with DBS ON compared to DBS OFF in the cognitive Yoni task because of high-frequency stimulation promoting voluntary actions at the expense of reflexive responses. 63,64 No significant group-level difference between DBS ON and OFF sessions is expected, considering the large individual variability in stimulation locations and parameters among patients. Further individual analyses revealed that patients with greater associative STN activation exhibited higher cognitive RT inference costs under DBS.…”

Section: Discussionmentioning

confidence: 99%

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Subthalamic Nucleus Stimulation Modulates Cognitive Theory of Mind in Parkinson's Disease

Xiao,

Lang,

et al. 2024

Movement Disorders

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BackgroundTheory of mind (ToM), the ability to infer others' mental state, is essential for social interaction among human beings. It has been widely reported that both cognitive (inference of knowledge) and affective (inference of emotion) components of ToM are disrupted in Parkinson's disease (PD). Previous studies usually focused on the involvement of the prefrontal cortex.ObjectiveThis study investigated the causal role of the subthalamic nucleus (STN), a key hub of the fronto‐basal ganglia loops, in ToM.MethodsThirty‐four patients with idiopathic PD (15 women, aged 62.2 ± 8.3 years) completed a Yoni task with deep brain stimulation (DBS) ON and OFF. The Yoni task was designed to separate the cognitive and affective components of ToM. Volumes of tissue activated (VTA) were computed for three subregions of the STN.ResultsDBS showed insignificant effects on ToM inference costs at the group level, which may be due to the large interindividual variability. The associative VTA correlated with the cognitive inference cost change but not the affective inference cost change. Patients with greater associative STN stimulation infer more slowly on cognitive ToM. Stimulating associative STN can adversely affect cognitive ToM in PD patients, especially in patients with a wide range of stimulation (≥0.157) or cognitive decline (Montreal Cognitive Assessment < 26).ConclusionsThe associative STN plays a causal role in cognitive ToM in patients with PD. However, stimulating the associative STN likely impairs cognitive ToM and potentially leads to social interaction deficits in PD. © 2024 International Parkinson and Movement Disorder Society.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Subthalamic Nucleus Stimulation Modulates Cognitive Theory of Mind in Parkinson's Disease

Xiao,

Lang,

et al. 2024

Movement Disorders

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Clinical challenges and opportunities related to the biological responses experienced by indwelling and implantable bioelectronic medical devices

Robinson,

Voelcker,

Thissen

2024

Acta Biomaterialia

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Non-Motor Effects of Low-Frequency Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson’s Disease: A Systematic Review

Ong,

Schmidt,

Tosefsky

et al. 2024

Stereotact Funct Neurosurg

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Introduction: Deep brain stimulation of the subthalamic nucleus is an effective therapy for the motor symptoms of Parkinson’s disease (PD). Typically, stimulation is applied at a high frequency (≥100 Hz) to alleviate motor symptoms. However, the effects on non-motor symptoms can be variable. Low-frequency oscillations are increasingly recognized as playing an important role in the non-motor functions of the subthalamic nucleus. Therefore, it has been hypothesized that low-frequency stimulation of the subthalamic nucleus (<100 Hz) may have a direct effect on these non-motor functions, thereby preferentially impacting non-motor symptoms of PD. Despite important therapeutic implications, the literature on this topic has not been summarized. Method: To understand the current state of the field, we performed a comprehensive systematic review of the literature assessing the non-motor effects of low-frequency stimulation of the subthalamic nucleus in PD. We performed a supplementary meta-analysis to assess the effects of low- versus high-frequency stimulation on verbal fluency outcomes. Results: Our search returned 7,009 results, of which we screened 4,199 results. A total of 145 studies were further assessed for eligibility, and a total of 21 studies met our inclusion criteria, representing 297 patients. These studies were a mix of case reports and control trials. The four clinical outcomes measured were sleep, sensory perception, cognition, and mood. A supplementary meta-analysis of six studies investigating the impact of low-frequency stimulation on verbal fluency did not find any significant results when pooling across subgroups. Conclusion: LFS of the STN may have benefits on a range of cognitive and affective symptoms in PD. However, current studies in this space are heterogeneous, and the effect sizes are small. Factors that impact outcomes can be divided into stimulation and patient factors. Future work should consider the interactions between stimulation location and stimulation frequency as well as how these interact depending on the specific non-motor phenotype.

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High (130 Hz)- and mid (60 Hz)-frequency deep brain stimulation in the subthalamic nucleus differentially modulate response inhibition: A preliminary combined EEG and eye tracking study

Cited by 3 publications

References 96 publications

Subthalamic Nucleus Stimulation Modulates Cognitive Theory of Mind in Parkinson's Disease

Subthalamic Nucleus Stimulation Modulates Cognitive Theory of Mind in Parkinson's Disease

Clinical challenges and opportunities related to the biological responses experienced by indwelling and implantable bioelectronic medical devices

Non-Motor Effects of Low-Frequency Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson’s Disease: A Systematic Review

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