High 15-F_2t-Isoprostane Levels in Patients with a Previous History of Nonmelanoma Skin Cancer: The Effects of Supplementary Antioxidant Therapy

Abstract

Background. Phase I of this study was aimed at comparing the profiles of oxidative stress biomarkers in patients with history of nonmelanoma skin cancer (NMSC), previously treated with surgery, to the healthy subjects. Phase II aimed to evaluate the effects of supplementary antioxidant therapy on the levels of biomarkers in the case group. Materials and Methods. In Phase I, oxidative stress biomarkers were measured in blood samples obtained from 24 healthy subjects and 60 patients with history of NMSC previously treated with surgery. In Phase II, the 60 patients with history of NMSC were randomized into two subgroups, one receiving placebo (n = 34) and the other (n = 26) receiving vitamin C, vitamin E, and zinc supplementation for 8 weeks, followed by reevaluation of biomarkers. Results. In Phase I, patients with history of NMSC showed increased plasma concentrations of all biomarkers, but only 15-F2t-isoprostane was significantly higher than in the healthy subjects. Risk of NMSC increased by 4% for each additional 1 pg/mL increase in 15-F2t-isoprostane. In Phase II, supplementation did not significantly reduce levels of oxidative stress biomarkers. Conclusion. Patients with history of NMSC had significantly high 15-F2t-isoprostane plasma levels; supplementation did not result in significant reduction of oxidative stress biomarkers. This trial was registered with ClinicalTrials.gov (ID NCT02248584).

Two Faces of Vitamin C—Antioxidative and Pro-Oxidative Agent

“…Other clinical studies have not shown significant influence on various cancers: breast [62], colorectal, pancreatic, biliary tract, gastric [63]. However, other results of clinical studies show that the administration of antioxidants during cancer therapy caused a decrease in the level of markers of oxidative stress in blood serum [64]. The general disease state of cancer patients, dietary deficiencies, the body's greater antioxidants requirements due to increased oxidative stress cause depletion of antioxidants such as vitamin C. Intravenous infusions of vitamin C are proposed to supplement deficiencies and a factor supporting the eradication of, e.g., CSC cancer stem cells [65].…”

The Role of Vitamin C in Cancer Prevention and Therapy: A Literature Review

“…The study continued with a phase II clinical trial (NCT2905578) still in development. In a related phase I clinical trial (NCT02248584), changes in plasmatic 15-F2t isoprostanes were not found in 60 patients with skin cancer supplemented with vitamin C, E, and Zn [ 60 ]. The phase I clinical trial study NCT01364805 included 14 patients with advanced or metastatic pancreatic cancer and showed a decrease in metastasis and cancer cell proliferation ( Table 1 ).…”

A phase II randomized, double-blind, placebo-controlled study of Nuvastatic (C50SEW505OESA), a standardized rosmarinic acid-rich polymolecular botanical extract formulation to reduce cancer-related fatigue in patients with solid tumors

“…Several dietary antioxidants are used as natural chemopreventive agents to reduce the excess concentrations of oxidative molecules and shift their concentrations closer to the normal physiological concentrations [7,12]. Several herbal products (turmeric, ginger, and ginseng), have been investigated to treat CRF [13].…”