High Accumulation of Calcium in Human Uterine Artery with Aging

Abstract

To elucidate compositional changes of the rami of the internal iliac artery with aging, the authors investigated age-related changes of the calcium content in the uterine, internal pudendal, umbilical, and obturator arteries by inductively coupled plasma-atomic emission spectrometry. After an ordinary dissection was finished, the uterine, internal pudendal, umbilical, and obturator arteries were resected from 10 female subjects, and the internal pudendal, umbilical, and obturator arteries were resected from 10 male subjects. The female subjects ranged in age from 52 to 96 yr, and the male subjects ranged in age from 63 to 88 yr. The calcium content in the uterine artery began to increase in the seventies and increased markedly in the nineties. In the internal pudendal artery, the calcium content hardly increased up to the eighties and increased significantly in the nineties. In contrast, the calcium content did not change in both the umbilical and obturator arteries with advancing age. It was found that the average content of calcium was the highest in the uterine artery and decreased in the order internal pudendal, umbilical, and obturator arteries. The average content of calcium in the uterine arteries corresponded to 46-fold the amount of the women's obturator arteries, in which it was the lowest. In the cases of men, the average content of calcium was higher in the order of the internal pudendal, umbilical, and obturator arteries. Regarding the average content of calcium, the order internal pudendal, umbilical, and obturator arteries of the men was consistent with that of the women.

Age-dependent Increases of Calcium, Phosphorus, and Sodium in the Uterine Arteries of Thai

“…The authors [6] previously found that a much higher accumulation of Ca occurred in the aged uterine arteries in comparison with the other branches of the internal iliac artery, such as the internal pudendal, umbilical, and obturator arteries.…”

“…They revealed that atherosclerosis of the uterine artery appeared to correlate with age. The authors [6,7] previously investigated age-related changes of elements in the uterine arteries of Japanese more than 58 years of age and found that a significant accumulation of Ca and P in the uterine arteries was found in the sixties and the accumulation increased markedly in the eighties. Regarding the uterine arteries in subjects more than 60 years, the extent of accumulation of Ca and P in the uterine arteries of Japanese [7] was two times higher than that in the uterine arteries of Thai with the exception of the seventies.…”

“…However, few studies had been conducted on the element contents in the uterine artery by direct chemical analysis. Therefore, the authors [6] previously investigated age-related changes of Ca in the branches of the internal iliac artery, such as the uterine, internal pudendal, umbilical, and obturator arteries, and found that a much higher accumulation of Ca occurred in the uterine artery with aging in comparison with the internal pudendal, umbilical, and obturator arteries. Furthermore, the authors [7] investigated age-related changes of six elements as well as Ca in the uterine arteries of Japanese and found that the Ca, P, and Na contents increased progressively in the uterine arteries with aging.…”

Moderate Accumulation of Calcium and Phosphorus in the Splenic Artery with Aging and Low Accumulation of Those in the Pulmonary Artery with Aging

“…To elucidate compositional changes of the arteries with aging, the authors [1][2][3][4][5][6][7][8][9] investigated age-related changes of elements in the arteries. It was found out that the accumulation of Ca and P did not occur uniformly in any arteries with aging and a high accumulation of Ca and P occurred in the thoracic and abdominal aortas, coronary, common iliac, internal iliac, external iliac, femoral, and uterine arteries, but it hardly occurred in the axillary, brachial, radial, ulnar, and obturator arteries.…”