High accumulation of tilianin in in-vitro cultures of Agastache mexicana and its potential vasorelaxant action

Carmona-Castro, Gabriela; Estrada‐Soto, Samuel; Arellano-García, Jesús; Arias-Durán, Luis; Valencia-Díaz, Susana; Perea-Arango, Irene

doi:10.1007/s11033-018-4570-4

Cited by 12 publications

(20 citation statements)

References 49 publications

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“…Plant-tissue cultures of A. mexicana ssp. mexicana further confirmed the observed in vivo antihypertensive and vasorelaxant effects in SHR [ 33 , 35 ]. Tilianin isolated from methanolic extracts obtained from in vitro plantlets and calli confirmed the conservation of its vasorelaxant effects.…”

Section: A Holistic Approach To Agastache Mexicana Usagesupporting

confidence: 63%

“…It also differs with respect to essential oils or extracts, as well as secondary metabolites present in them. Terpenes and flavonoids, such as ursolic acid, oleanolic acid, acacetin, apigenin, and tilianin, are the most active [ 33 ]. In some studies, where the biological activity of A. mexicana is determined, the studied subspecies is not specified.…”

Section: A Holistic Approach To Agastache Mexicana Usagementioning

confidence: 99%

“…Tilianin isolated from methanolic extracts obtained from in vitro plantlets and calli confirmed the conservation of its vasorelaxant effects. The in vitro methanolic extracts contained a higher concentration of tilianin and produced a stronger vasorelaxant effect on aorta rat rings than extracts from wild plants [ 33 ] ( Table 3 ).…”

Section: A Holistic Approach To Agastache Mexicana Usagementioning

confidence: 99%

“…The holistic approach to studying the A. mexicana species focuses on biology, ethnobotany, chemical composition, and biological activity. The species has potential pharmacological uses as a source of bioactive compounds, such as tilianin, acacetin, apigenin, ursolic acid, and oleanolic acid [ 33 ] in areas such as drug development, disease modeling, and other biological explorations [ 47 ].…”

Section: Potential and Perspectivesmentioning

confidence: 99%

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A Systematic Approach to Agastache mexicana Research: Biology, Agronomy, Phytochemistry, and Bioactivity

2021

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Mexico is the center of origin of the species popularly known as toronjil or lemon balm (Agastache mexicana Linton & Epling). Two subspecies have been identified and are commonly called purple or red (Agastache mexicana Linton & Epling subspecies. mexicana) and white (Agastache mexicana subspecies xolocotziana Bye, E.L. Linares & Ramamoorthy). Plants from these subspecies differ in the size and form of inflorescence and leaves. They also possess differences in their chemical compositions, including volatile compounds. Traditional Mexican medicine employs both subspecies. A. mexicana exhibits a broad range of pharmacological properties, such as anti-inflammatory, anxiolytic, and antioxidant. A systematic vision of these plant’s properties is discussed in this review, exposing its significant potential as a source of valuable bioactive compounds. Furthermore, this review provides an understanding of the elements that make up the species’ holistic system to benefit from lemon balm sustainably.

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Section: A Holistic Approach To Agastache Mexicana Usagesupporting

confidence: 63%

Section: A Holistic Approach To Agastache Mexicana Usagementioning

confidence: 99%

Section: A Holistic Approach To Agastache Mexicana Usagementioning

confidence: 99%

Section: Potential and Perspectivesmentioning

confidence: 99%

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A Systematic Approach to Agastache mexicana Research: Biology, Agronomy, Phytochemistry, and Bioactivity

2021

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“…Several effects on the central nervous system, such as sedation, reduced locomotor activity and central nervous system inhibition, were observed after administration of low doses of A. mexicana [ 64 ]. Moreover, tilianin, a bioactive compound of A. Mexicana , has vasorelaxant [ 65 ] and anxiolytic-like activity [ 66 ], without toxic effects [ 67 ]. On the other hand, ursolic acid and acacetin ( Figure 1 ) are responsible for the antinociceptive properties of this plant [ 30 , 68 , 69 ], suggesting the participation of cGMP and 5-HT 1A receptors.…”

Section: Preclinical Studies Of Mexican Medicinal Plants Used In Inflammatory and Neuropathic Pain Treatmentmentioning

confidence: 99%

Mexican Plants and Derivates Compounds as Alternative for Inflammatory and Neuropathic Pain Treatment—A Review

Quiñonez-Bastidas

Navarrete

2021

Plants

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Despite the availability of many anti-pain drugs, in the form of NSAIDs, steroids, gabapentinoids, opioids, and antidepressants, in this study we address the natural compounds belonging to the group of Mexican medicinal plants or “Mexican folk medicine”, used for pain management in Mexico. Our interest in this subject is due to the growing idea that “natural is harmless” and to the large number of side effects exhibited in pharmacotherapy. The objective of this review was to document the scientific evidence about Mexican medicinal plants and their derivatives used for inflammatory and neuropathic pain treatment, as well as the mechanisms of action implicated in their antinociceptive effects, their possible adverse effects, and the main pharmacological aspects of each plant or compound. Our data review suggested that most studies on Mexican medicinal plants have used inflammatory experimental models for testing. The anti-pain properties exerted by medicinal plants lack adverse effects, and their toxicological assays report that they are safe to consume; therefore, more studies should be performed on preclinical neuropathic pain models. Moreover, there is no convincing evidence about the possible mechanisms of action involved in the anti-pain properties exerted by Mexican plants. Therefore, the isolation and pharmacological characterization of these plant derivatives’ compounds will be important in the design of future preclinical studies.

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Functional properties of bioactive compounds contained in vegetables commonly consumed in Mexico

Lilia Alejandra,

Diego,

Diego

et al. 2023

Studies in Natural Products Chemistry

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High accumulation of tilianin in in-vitro cultures of Agastache mexicana and its potential vasorelaxant action

Cited by 12 publications

References 49 publications

A Systematic Approach to Agastache mexicana Research: Biology, Agronomy, Phytochemistry, and Bioactivity

A Systematic Approach to Agastache mexicana Research: Biology, Agronomy, Phytochemistry, and Bioactivity

Mexican Plants and Derivates Compounds as Alternative for Inflammatory and Neuropathic Pain Treatment—A Review

Functional properties of bioactive compounds contained in vegetables commonly consumed in Mexico

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