This paper presents a DFT/IDFT-free receiving scheme for spread-OFDM signals. Leveraging sub-Nyquist sampling and proper sampling delay, the proposed scheme enables each user to receive the requested data without the need for DFT and IDFT; thus, the complexity at receiver can be greatly reduced. Nonetheless, DC component is altered in an AC coupling system, such that severe waveform distortion is caused when the process of DFT/IDFT is omitted. Thus, a DC-zeroing algorithm is proposed to guarantee constant DC after sub-Nyquist sampling, thereby eliminating such distortion. To experimentally verify the concept of proposed scheme, a 27.15-Gbit/s optical spread-OFDM signal was transmitted over fiber and received by the DFT/IDFT-free scheme with sub-Nyquist sampling. More users will reduce the required sampling rate at receiver; for the case of 16 users, the required sampling rate for the 27.15-Gbit/s signal is as low as 1 GSample/s. The experimental results show that error-free transmission was achievable, and the penalty due to lowering sampling rate (i.e., increasing the number of users) is insignificant.