High Acoustic Nonlinearity of a Liquid Containing Microbubbles

Liu, Jiehui; Zhang, Dong; Gong, Xun; Shao, Li-Zheng; Li, Xiaorong; Chen, Xi; Zhang, Qin-lan

doi:10.1088/0256-307x/16/10/013

Cited by 2 publications

(12 citation statements)

References 3 publications

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“…Alil-1,2,3,4-tetrahidro-2-(2-bromoalil) 6,8,9,12,13,13a-heptahidro-2,3-dimetoksi-izohino[2,1-b 5; 147,4; 132,7; 132,0; 129,5; 126,5; 123,1; 122,9; 111,3; 108,3; 58,9 (C-13a); 58,0 (C-8); 56,0 (OCH 3 ); 55,8 (OCH 3 ); 52,2 (2C, COOCH 3 ); 51,0 (C-6); 36,9 (C-13); 32,3 (C-12); 30,2 (C-9); 28,9 (C-5). 6,8,9,12,13,13a-heptahidro-izohino[2,1-b CDCl 3 ) δ 167,3 (C=O estar ); 137,9; 136,4; (C-11); 134,4; 128,8; 127,3; 126,0; 125,9; 125,2; 124,5; 122,9; 59,4 (C-13a); 58,7 (C-8); 51,6 (COOCH 3 ); 50,9 (C-6); 36,9 (C-13); 31,9 (C-12); 29,4 (C-5); 27,9 (C-9); m/z ( 4; 134,4; 132,1; 129,1; 128,8; 128,5; 127,9; 127,4; 126,6; 126,1; 125,9; 125,3; 59,0 (C-13a) (m,4H',ArH),7,09 (m,5H,ArH),3,43 (m,1H,3,27 (m,3H,3,12 (m,1H,, 3,08-3,05 (m, 1H, H-6). 3,03-2,99 (m, 1H, H-8) 4; 134,2; 132,0; 129,2; 128,8; 128,7; 128,4; 128,1; 126,4; 126,2; 126,1; 125,4; 59,5 (C-13a) 129,2; 129,0; 128,6; 128,3; 128,2; 128,1; 126,7; 126,4; 126,1; 126,0; 125,3; 60,5 (C- 6,8,13,13a-pentahidro-izohino[2,1-b]izohinolin-10,11-dikarboksilat (2.24) Fleš hromatografijom (silika-gel, 8: 4; 138,0; 137,1; 134,4; 130,0; 129,4; 129,3; 128,9; 126,9; 126,4; 126,2; 125,4; 59,3 (C- 138,7; 136,4; 135,7; 130,5; 130,2; 129,5; 128,1; 127,7; 127,4; 126,7; 125,4; 125,1; 101,8 (C-13); 52,9 (CH 3 ); 52,6 (CH 3 ); 39,9 (C-6); 28,3 (C-5).…”

Section: N-(2-brom-2-propenil)-3-metil-izohinolinijum Bromid (211)mentioning

confidence: 99%

“…Hz, CH 3 ); 13 C NMR (125 MHz, CDCl 3 ) δ 168,4 (C=O estar ); 166,6 (C=O estar ); 160,8 (C=O amid ); 139,6; 138,7; 136,3; 133;3; 130,5; 130,4; 129,3; 128,9; 127,6; 127,3; 126,7; 125,3 5,6,8-trihidro-8-okso-izohino[2,1-b 6 Hz,7,84 (m,1H,7,62 (d,1H,J=8,2 Hz,7,38 (m,2H,7,30 (m,1H,, 7,04 (s,1H,4,39 (t,2H,J=6,1 Hz,, 3,97…”

Section: -mentioning

confidence: 99%

“…140,3; 134,1; 133,4; 131,7; 130,8; 129,4; 129,1; 128,6; 128,3; 128,2; 127,7; 127,4; 126,5; 125,4; 125,3 6; 139,1; 137,1; 135,9; 135,1; 129,9; 129,2; 127,8; 127,4; 127,2; 125,7; 124,8; 122,4 (C-1) 9; 138,5; 136,9; 135,5; 135,3; 130,0; 129,4; 128,3; 127,6; 125,3; 124,9; 123,8; 122,9; 102,4 (C-13); 60,3 (CH 2 OH); 60,1 (CH 2 OH); 40,9 (C-6); 27,9 (C-5); m/z (ESI): 308,0; 227,1; 198,9; 155.1; 6,8,13,13a-pentahidro-2,3-dimetoksi-izohino[2,1-b 138,3; 138,2; 136,9; 134,6; 129,9; 129,3; 129,2; 128,3; 127,4; 126,3; 126,2; 125,3; 60,3 (C-13a); 53,9 (C-6); 53,7 (C-8); 52,5 (COOCH 3 ); 38,5 (C-13); 37,6 (C-5); 20,2 (CH 3 ). 1; 134,7; 128,8; 128,3; 126,3; 125,6; 118 , 6; 147,1; 139,6; 127,8; 126,8; 126,2; 118,0; 111,5; 111,3 (ArH); 111,1 (ArH); 65,8 (C-1); 65,5 (CH 2 CI=CH 2 ); 55,9 (OCH 3 ); 55,8 (OCH 3 ); Hz, H-1), 6,01 (d,1H,J=10,0 Hz,, 4,90 (s, 1H, C=CH 2 ), 4,88 (s, 1H, C=CH 2 ), 4,46 (s, 1H, H-11b), 3,64 (dt, 1H, J 1 =14,5 Hz, J 2 =2,0 Hz, H-4), 3,52 (d,1H,J=14,5 Hz, (d, 1H, J=8,0 Hz, ArH), 7,40 (d,1H,J=8,0 Hz,ArH),7,12 (m,2H,ArH),3,95 (t,2H,J=8,4 Hz, 8; 125,4; 124,7; 120,5; 120,0; 116,3; 112,0; 48,5 (C- 2; 135,7; 134,8; 127,0; 126,6; 121,6; 119,4; 118,1; 117,5; 111,8; 110,7; 108,1; 64,8; 56.7; 44,7; 39,4; (d,1H,J=8,0 Hz,, 7.31…”

Section: -unclassified

“…1; 134,7; 128,8; 128,3; 126,3; 125,6; 118 , 6; 147,1; 139,6; 127,8; 126,8; 126,2; 118,0; 111,5; 111,3 (ArH); 111,1 (ArH); 65,8 (C-1); 65,5 (CH 2 CI=CH 2 ); 55,9 (OCH 3 ); 55,8 (OCH 3 ); Hz, H-1), 6,01 (d,1H,J=10,0 Hz,, 4,90 (s, 1H, C=CH 2 ), 4,88 (s, 1H, C=CH 2 ), 4,46 (s, 1H, H-11b), 3,64 (dt, 1H, J 1 =14,5 Hz, J 2 =2,0 Hz, H-4), 3,52 (d,1H,J=14,5 Hz, (d, 1H, J=8,0 Hz, ArH), 7,40 (d,1H,J=8,0 Hz,ArH),7,12 (m,2H,ArH),3,95 (t,2H,J=8,4 Hz, 8; 125,4; 124,7; 120,5; 120,0; 116,3; 112,0; 48,5 (C- 2; 135,7; 134,8; 127,0; 126,6; 121,6; 119,4; 118,1; 117,5; 111,8; 110,7; 108,1; 64,8; 56.7; 44,7; 39,4; (d,1H,J=8,0 Hz,, 7.31 (d,1H,J=8,0 Hz,7,12 (m,2H,5,18 (m, 4; 143,9; 136,1; 134,1; 127,2; 121,6; 119,5; 118,2; 110,8 (C-11); 110,3 (C 2 =CH 2 ); 110,1 (C 3 136,3; 134,1; 132,7; 131,9; 127,2; 123,7; 122,1; 121,6; 119,5; 118,3; 110,8; 108,7; 57,3 (C-21); 55,8 (C-3); 52,…”

Section: -mentioning

confidence: 99%

“…86 (s, 1H, N-H), 7,81 (s,1H,7,44 (m,4H,),7,33 (m,4H),7,25 (m,2H),7,19 (m,4H),7,09 (m,4H),3,55 (brd,1H,J=10,0 Hz),3,45 (brs,1H),3,38 (d,1H,J=17,5 Hz),3,30 (m,1H),3,26 (m,4H),3,13 (m,3H) (C=O imid ); 136,2 (2C), 134,3; 133,9; 132,0; 129,2; 129,1; 129,0; 128,7; 128,6; 128,6; 128,1; 127,5; 127,1; 127,0; 126,7; 126,6; 126,3; 121,6; 121,5; 119,5; 118,2; 118,1; 110,8 (2C); 108,5; 60,4; 57,8; 57,7; 56,0; 55,5; 51,8; 51,7; 40,2; 39,4 (2C); 39,3; 36,2; 35,4; 28,9; 28,4; 27,0; 26,9; 21,5; 21,3; 21, 3283,2922,1699,1621,1606,1439,1299,1284,1148,1231, 737 cm −1 1 H NMR (500 MHz, CDCl 3 ) δ 8,…”

Section: -mentioning

confidence: 99%

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Annulations of heterocyclic compounds and their application in synthesis of natural compounds

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The aim of this thesis was the development of a synthetic route for protoberberine derivatives, polycyclic compounds containing the isoquinoline skeleton. The protoberberines are widespread, important group of isoquinoline alkaloids. Due to the potent pharmacological properties they have attracted an attention from medicinal chemist and drug researchers. Our proposed synthetic route enabling access to different classes of protoberberines is based on a common intermediate, an isoquinolinic 1,3-diene. The incorporation of ring C in various oxidative states, as well as the incorporation of additional substituents necessary for the functionalisation of ring D of protoberberines was achieved through Diels-Alder reactions with different dienophiles and the subsequent oxidation of the resulting cycloadducts. Two types of natural products' skeletons, tetrahydroprotoberberines and oxoprotoberberines were efficiently synthesised using this approach. This synthetic methodology proved to be applicable in the preparation of dihydro-β-carbolines and pyridines. Alkaloids derived of β-carboline are important compounds with a broad spectrum of biological activities. Starting with dihydro-β-carboline, through the corresponding intermediary 1,3diene, ketoyobirines and dihydrogambirtanines were obtained. Pyridine had also shown amenable to these types of annulations, giving benzoquinolizine structures. In vitro cytotoxic activity of some synthetised isoquinolines and β-carbolines was investigated (FemX, HeLa, K562). Cycloadduct 2.17 shows the greatest cytotoxic activity of the compounds tested, with IC 50 value of 24,7 µM towards K562 cells. In addition to this, the possibility of functionalization of 1,3-diene system in Pdcatalysed reaction was also explored, enabling access to different allylic acetates with isoquinoline and β-carboline structure. A synthetic route to benzazepine derivatives of isoquinoline, β-carboline and pyridine was also developed and some of the compounds obtained have shown a substantial protective effect on the DNA of human lymphocites, surpassing that of a commercial radioprotective agent amifostine. In vitro cytotoxic activity against cancer cell lines some synthetised benzazepine was tested (FemX, HeLa, K562). IC 50 Values of benzazepine derivatives range of 17,49-74,70 µM.

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Section: N-(2-brom-2-propenil)-3-metil-izohinolinijum Bromid (211)mentioning

confidence: 99%

Section: -mentioning

confidence: 99%

Section: -unclassified

Section: -mentioning

confidence: 99%

Section: -mentioning

confidence: 99%

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Nonlinear inversion of ultrasonic guided waves for in vivo evaluation of cortical bone properties

Song¹,

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et al. 2022

Chinese Phys. B

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Ultrasonic guided waves (UGW), which propagate throughout the whole thickness of cortical bone, are attractive in the early diagnosis of osteoporosis. However, it is challenging due to the impact of soft tissue and the inherent difficulties related to the multiparametric inversion of cortical bone quality factors, such as cortical thickness and bulk wave velocities. Therefore, an UGW based multiple-parameter inversion algorithm is developed to predict strength-related factors in this research. In simulation, a free plate (cortical bone) and a bilayer plate (soft tissue and cortical bone) are used to validate the proposed method. The inverted cortical thickness (CTh), longitudinal velocity (V L ) and transverse velocity (V T ) are in accordance with the true value. Then four bovine cortical bone plates are used in the in vitro experiments. Compared with the reference values, the relative errors for cortical thicknesses are 3.96%, 0.83%, 2.87% and 4.25% respectively. In the in vivo measurements, ultrasonic guided waves are collected from ten volunteers’ tibia. The theoretical dispersion curves depicted by the estimated parameters (V T , V L , CTh) match well with the extracted experimental ones. In comparison to the dual-energy x-ray absorptiometry (DXA), the results show that the estimated transverse velocity and cortical thickness are highly sensitive to the osteoporosis. Therefore, these two parameters (CTh and V T ) of long bones have potential to diagnose bone status in clinical applications.

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High Acoustic Nonlinearity of a Liquid Containing Microbubbles

Abstract: LI Xiao-rong(% ?&)2, CHEN Xi(K#)l, ZHANG Qin-lan(%Fg)2

Cited by 2 publications

References 3 publications

Annulations of heterocyclic compounds and their application in synthesis of natural compounds

Annulations of heterocyclic compounds and their application in synthesis of natural compounds

Nonlinear inversion of ultrasonic guided waves for in vivo evaluation of cortical bone properties

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