High affinity interaction of <scp><i>Solanum tuberosum</i></scp> and <scp><i>Brassica juncea</i></scp> residue smoke water compounds with proteins involved in coronavirus infection

Dave, Gaurav S.; Rakholiya, Kalpna; Kaneria, Mital J.; Galvadiya, Bhemji P.; Vyas, S. R.; Kanbi, Vaktabhai H.; Patel, M. B.

doi:10.1002/ptr.6796

Cited by 19 publications

(11 citation statements)

References 70 publications

(79 reference statements)

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“…As shown in table 1, docking score represent the maximum selectivity and binding affinity of MB with PLpro followed by TMPRSS2 and SARS-CoVRdRp. These results of docking study are in accordance with the previous findings of same protein targets [11] and utilization of MB [12] as a promising molecule to combat the coronavirus pandemic. As shown in table 1, MB showed selectivity against receptors which are found to be pivotal in attachment and infection of coronavirus in host cells [2,5,6] .…”

Section: Introductionsupporting

confidence: 91%

“…As shown in table 1, MB showed selectivity against receptors which are found to be pivotal in attachment and infection of coronavirus in host cells [2,5,6] . Additionally, MB exhibited remarkable high affinity binding with protein targets compared to HCQ [11] . Moreover, MB has not been found with any reported side effect like hydroxycholorquine, which is responsible for cardiac arrhythmias [13] .…”

Section: Introductionmentioning

confidence: 99%

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Why not methylene blue over the HCQ and remdesvir

Patel¹

2021

Pharma Innovation

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Severity of COVID -19 pandemic discourse the novel treatment and approach against viral infection. Repurposing of various drugs are exercised to treat the corona infection. Available resources of drugs are not targeting the key ligands of the virus and host interaction. Methylene blue is widely utilized to treat the patients of COVID -19 in India. In silico approach attracted the focus to study its role in binding with different proteins involved in infection. Total ten different proteins were selected to study the efficiency binding of methylene blue. Docking study revealed favorable binding score of methylene blue against the studied proteins. Present study disclosed the methylene blue as a promising molecule to treat the infectivity of virus, after confirmation through in vitro and in vivo study.

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Section: Introductionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Why not methylene blue over the HCQ and remdesvir

Patel¹

2021

Pharma Innovation

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“…Sphingosine has been confirmed to prevent the binding of SARS‐CoV‐2 spikes to its cellular receptor ACE2 (Edwards et al., 2020 ). Its derivatives also act as a selective and potent candidate for COVID‐19 treatment (Dave et al., 2020 ). In addition, sphingosine 1‐phosphate mediated signaling was suggested to be a potential target for ameliorating neurological symptoms induced by SARS‐CoV‐2 (Meacci et al., 2020 ).…”

Section: Discussionmentioning

confidence: 99%

An epigenome‐wide DNA methylation study of patients with COVID‐19

Zhou

Zhang

et al. 2021

Annals of Human Genetics

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In the early 2000s, emerging SARS‐CoV‐2, which is highly pathogenic, posed a great threat to public health. During COVID‐19, epigenetic regulation is deemed to be an important part of the pathophysiology and illness severity. Using the Illumina Infinium Methylation EPIC BeadChip (850 K), we investigated genome‐wide differences in DNA methylation between healthy subjects and COVID‐19 patients with different disease severities. We conducted a combined analysis and selected 35 “marker” genes that could indicate a SARS‐CoV‐2 infection, including 12 ( ATHL1 , CHN2 , CHST15 , CPLX2 , CRHR2 , DCAKD , GNAI2 , HECW1 , HYAL1 , MIR510 , PDE11A , and SMG6 ) situated in the promoter region. The functions and pathways of differentially methylated genes were enriched in biological processes, signal transduction, and the immune system. In the “Severe versus Mild” group, differentially methylated genes, after eliminating duplicates, were used for PPI analyses. The four hub genes ( GNG7 , GNAS , PRKCZ , and PRKAG2 ) that had the highest degree of nodes were identified and among them, GNG7 and GNAS genes expressions were also downregulated in the severe group in sequencing results. Above all, the results suggest that GNG7 and GNAS may play a non‐ignorable role in the progression of COVID‐19. In conclusion, the identified key genes and related pathways in the current study can be used to study the molecular mechanisms of COVID‐19 and may provide possibilities for specific treatments.

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“…Antiviral activity of this plant against influenza virus was found through invitro studies (Lee et al, 2014). Curcumenol and N-Desmethylselegiline, two constituents of this plant, showed potential to be selective and strong lead compound against COVID-19 in-silico (Dave et al, 2020). Further studies are required to make conclusive decision in this regard.…”

Section: Garlicmentioning

confidence: 93%

Potential of Prospective Medicinal Plants of Bangladesh for the Complementary Management of COVID-19

et al. 2022

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The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has been a healthcare disaster because of the unique and distinct characteristics of the pathogen, the easy and rapid transmission of the virus from humans to humans, the challenges in diagnosis and confirmation of the disease and the inability to invent and distribute safe and effective drugs or vaccines worldwide that would work against all the variants of coronavirus. Bangladesh, despite being a third-world country with limited health resources, has not been one of the worst-hit countries in the world but has still suffered with the loss of nearly eleven thousand people. Traditional and herbal remedies have become popular in this sub-continent since long ago and used for the treatment and management of different diseases including infectious disease. In this review, we have summarized the reports of immunostimulating, anti-inflammatory, antiviral, and respiratory distress syndrome improving activities of prospective indigenous plants of Bangladesh that may be recommended for use as complementary and alternative medicine or may be potential sources for the discovery and development of anti-COVID-19 medicaments. Thus, the review will be beneficial for the researchers, complementary and alternative medicines or herbal medicine manufacturers, formulators to find out and manage the potential herbal/nutraceutical/medicinal agents for the preparation of complementary and alternative medicines, as well as to the scientist for further research for the discovery and development of therapeutics/new drugs for the prevention and treatment of COVID-19 as well as other viral infections. Bangladesh Pharmaceutical Journal 25(1): 89-114, 2022 (January)

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High affinity interaction of Solanum tuberosum and Brassica juncea residue smoke water compounds with proteins involved in coronavirus infection

Cited by 19 publications

References 70 publications

Why not methylene blue over the HCQ and remdesvir

Why not methylene blue over the HCQ and remdesvir

An epigenome‐wide DNA methylation study of patients with COVID‐19

Potential of Prospective Medicinal Plants of Bangladesh for the Complementary Management of COVID-19

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