2022
DOI: 10.1016/j.envres.2022.114206
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High-altitude exposure decreases bone mineral density and its relationship with gut microbiota: Results from the China multi-ethnic cohort (CMEC) study

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Cited by 19 publications
(11 citation statements)
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“…Second, we isolated 14 strains, while the previous study isolated four strains (Du et al, 2018). Because environmental conditions can affect bacteria community and induce mutations in Salmonella (Baert et al, 2021; Zuo et al, 2022), which potentially causes rapid changes to antimicrobial resistance patterns (Peruzy et al, 2020), variation in AST results might stem from distinct antibiotic pressures or host environmental diversity (Yin et al, 2021).…”
Section: Discussionmentioning
confidence: 99%
“…Second, we isolated 14 strains, while the previous study isolated four strains (Du et al, 2018). Because environmental conditions can affect bacteria community and induce mutations in Salmonella (Baert et al, 2021; Zuo et al, 2022), which potentially causes rapid changes to antimicrobial resistance patterns (Peruzy et al, 2020), variation in AST results might stem from distinct antibiotic pressures or host environmental diversity (Yin et al, 2021).…”
Section: Discussionmentioning
confidence: 99%
“…High-altitude environments may also affect bone density. A multicenter study conducted in China found a negative correlation between altitude and quantitative ultrasound index (QUI) of bones, with Streptococcus playing a significant mediating role, suggesting that high-altitude exposure may reduce adult bone density, thereby increasing the risk of osteoporosis, with potential involvement of the intestinal microbiota ( Zuo et al, 2022 ).…”
Section: Impact Of Intestinal Microbiota Alterations On Organismal He...mentioning
confidence: 99%
“…Factors such as hypobaric hypoxia, low temperatures, and high radiation not only impact organismal reproduction and survival but also accelerate population-level evolution and physiological adaptations ( Hu et al, 2022 ). These conditions may also precipitate high-altitude reactions or illnesses in susceptible individuals, potentially leading to dysbiosis in the intestinal microbiota ( Lan et al, 2017 ; Zuo et al, 2022 ).…”
Section: Introductionmentioning
confidence: 99%
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“…Future studies should focus on the comparison of different samples, e.g., saliva vs. tissue. In addition, geographic, race and diet differences may be the other factors for the conflicting findings [18,36,37]. For instance, patients in Aykut' s study were enrolled from the NYU Langone Medical Center, New York, United States, where Caucasians are the main race [3].…”
Section: Logistic Regression For Mycobiota Profilementioning
confidence: 99%