High-Altitude Headache

Marmura, Michael J.; Hernandez, Pablo Bandres

doi:10.1007/s11916-015-0483-2

Cited by 28 publications

(19 citation statements)

References 71 publications

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“…We detected a HAH incidence of 72.6% after high-altitude exposure in the current study, slightly lower than the incidence in previous studies [3,4]. One possible reason is that subjects are general young soldiers, and they take exercise and military training regularly, resulting in better physical fitness and hypoxia tolerance.…”

Section: Discussioncontrasting

confidence: 75%

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Association of EPAS1 and PPARA Gene Polymorphisms with High-Altitude Headache in Chinese Han Population

Shen

Zhang

Yang

et al. 2020

BioMed Research International

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Background. High-altitude headache (HAH) is the most common complication after high-altitude exposure. Hypoxia-inducible factor- (HIF-) related genes have been confirmed to contribute to high-altitude acclimatization. We aim to investigate a possible association between HIF-related genes and HAH in the Chinese Han population. Methods. In total, 580 healthy Chinese Han volunteers were recruited in Chengdu (500 m) and carried to Lhasa (3700 m) by plane in 2 hours. HAH scores and basic physiological parameters were collected within 18–24 hours after the arrival. Thirty-five single nucleotide polymorphisms (SNPs) in HIF-related genes were genotyped, and linkage disequilibrium (LD) was evaluated by Haploview software. The functions of SNPs/haplotypes for HAH were developed by using logistic regression analysis. Results. In comparison with wild types, the rs4953354 “G” allele (P=0.013), rs6756667 “A” allele (P=0.036) in EPAS1, and rs6520015 “C” allele in PPARA (P=0.009) were significantly associated with decreased risk of HAH. The rs7292407-rs6520015 haplotype “C-C” in PPARA was identified as a protective factor (P=0.030). Importantly, EPAS1 and PPARA genes have synergistic effects in decreasing HAH risk (P=0.003). Conclusions. EPAS1 and PPARA polymorphisms were associated with HAH in the Chinese Han population. Our findings pointed out potentially predictive gene markers, provided new insights into understanding pathogenesis, and may further provide prophylaxis and treatment strategies for HAH.

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Section: Discussioncontrasting

confidence: 75%

“…High-altitude headache (HAH) is the most frequent complaint in lowlanders who ascend from plain area to high altitude and occurs either as an isolated symptom or as a part of acute mountain sickness (AMS) [1][2][3][4]. According to Lake Louise AMS scoring system revised in 2018, headache is an indispensable symptom [5].…”

Section: Introductionmentioning

confidence: 99%

Association of EPAS1 and PPARA Gene Polymorphisms with High-Altitude Headache in Chinese Han Population

Shen

Zhang

Yang

et al. 2020

BioMed Research International

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“…Multiple studies have considered the relationship between migraine or headache and environmental factors such as weather. High altitude is a proven trigger of headache especially during rapid ascents (67). Living at high altitudes may cause chronic headache, especially in those lacking genetic adaptations to adapt to hypoxia (68).…”

Section: Weather Triggers In Migrainementioning

confidence: 99%

Triggers, Protectors, and Predictors in Episodic Migraine

Marmura

2018

Curr Pain Headache Rep

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137

103

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“…Gamboa et al [12] also reported that there was an association between depression and migraine in HA population. Migraine as altitude increases may be result from cellular hypoxia due to decreased barometric pressure [43]. The relationship between migraine and depression may be bidirectional, and genes from serotonergic and dopaminergic may be associated with the aetiology of both migraine and depression [42].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of depression and associated factors among Chinese military plateau drivers in Golmud, Qinghai Province, China: a cross-sectional study

et al. 2020

Preprint

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Background: Depression is associated with declining duty performance, suicide and other serious problems in the army. Prolonged deployment at high altitude may result in depression among military personnel. The present study aimed to investigate the prevalence of depression among Chinese military plateau drivers and determine the associated factors.Methods: The participants were military drivers selected from Golmud motor transport base (high altitude group) and Fuzhou motor transport base (low altitude group). All participants were asked to complete a self-administrated questionnaire. The questionnaire included demographic and working characteristics, the Self Rating Depression Scale (SDS), the 14-item Fatigue Scale (FS-14), the Global Assessment of Migraine Severity (GAMS), the numeric rating scale (NRS) for dyspnea, and item three of the Patient Health Questionnaire-9-item (PHQ-9) for screening sleep disturbance.Results: A total of 400 questionnaires were distributed (200 for each group); 400 questionnaires were collected (the response rate was 100%). After eliminating 16 invalid questionnaires, 194 plateau drivers and 190 lowland drivers provided valid response (96.0%). In comparison to lowland drivers, the plateau drivers had severer fatigue (t = 4.298, p < 0.001), severer migraine (t = 11.440, p < 0.001), severer breathlessness (t = 12.094, p < 0.001), severer sleep disturbance (t = 3.353, p = 0.001), and higher prevalence of depression symptoms (χ2 = 15.123, p < 0.001). The possibility of having depression symptoms was significantly higher among military plateau drivers who were suffering severer fatigue (OR = 1.14, 95% CI: 1.01-1.29), migraine (OR = 1.83, 95% CI: 1.13-2.95), breathlessness (OR = 1.69, 95% CI: 1.04-1.73), and sleep disturbance (OR = 1.78, 95% CI: 1.03-3.07).Conclusion: Prevalence of depression was high among Chinese military plateau drivers. The risk factors were fatigue, severity of migraine, severity of breathlessness, and poor sleep quality. It is essential to become aware of these risk factors and their causes to intervene and help prevention of depression among Chinese military plateau drivers.

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High-Altitude Headache

Cited by 28 publications

References 71 publications

Association of EPAS1 and PPARA Gene Polymorphisms with High-Altitude Headache in Chinese Han Population

Association of EPAS1 and PPARA Gene Polymorphisms with High-Altitude Headache in Chinese Han Population

Triggers, Protectors, and Predictors in Episodic Migraine

Prevalence of depression and associated factors among Chinese military plateau drivers in Golmud, Qinghai Province, China: a cross-sectional study

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