High Altitude Induced Pulmonary Hypertension and Right Heart Failure in Broiler Chickens

Cueva, S.F.; Sillau, H.; Valenzuela, Abel; Ploog, H. P.

doi:10.1016/s0034-5288(18)33737-8

Cited by 166 publications

(48 citation statements)

References 11 publications

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“…Extreme differences in diurnal and nocturnal temperatures experienced by the birds near Nairobi may be another important contributory factor in the present study, since nuclear abnormalities, including karyolysis, were frequently seen. When all these factors such as hypoxia, temperature and possibly increased erythropoeitin production are considered together, along with other corresponding increases in haematological parameters (Cueva et al, 1974), it would appear that the renal pathology of ascitic syndromes in young broilers probably progresses more rapidly at altitude than at sea level. Downloaded by [Fondren Library, Rice University ] at 07:57 25 November 2014…”

Section: Discussionmentioning

confidence: 99%

“…Although ascites have long been associated with flocks reared at high altitude (Hall and Machicao, 1968;Cueva et al, 1974;Agudelo, 1983;Huchzermeyer, 1984), more recently the incidence of ascites occurring at low altitudes has increased (Page, 1987;Julian et al, 1987). Ultrastructural changes in ascitic birds reared at low altitude (Maxwell et al, 1986) include cardiac myofibril damage, marked dilation of lung parabronchi, excessive lipid accumulation in the proximal convoluted tubules (PCT) of kidneys together with altered mitochondrial morphology and thickening of glomerular basement membranes.…”

Section: Introductionmentioning

confidence: 99%

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An ultrastructural study of an ascitic syndrome in young broilers reared at high altitude

Maxwell

Dolan

Mbugua³

1989

Avian Pathology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An ultrastructural study of an ascitic syndrome in young broilers reared at high altitude

Maxwell

Dolan

Mbugua³

1989

Avian Pathology

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“…Determination of right ventricle hypertrophy was performed as described by Cueva et al (1974). The heart was resected, and the atria were removed to the plane of the atrial-ventricular valves, then the total ventricles (TV) were weighed.…”

Section: Assessment Of Right Ventricle Hypertrophymentioning

confidence: 99%

Evaluation of endothelial and inducible nitric oxide synthase mRNA expression in the lung of broiler chickens with developmental pulmonary hypertension due to cold stress

Teshfam¹,

Brujeni

Hassanpour³

2006

British Poultry Science

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To clarify the effect of cold-induced pulmonary hypertension on endothelial and inducible nitric oxide synthase (eNOS and iNOS) mRNA expression in the lung of broiler chickens, semi quantitative reverse transcription-PCR was performed on total RNAs isolated from lungs of the broiler chickens exposed to 5 weeks of cold stress. The eNOS gene was expressed increasingly with the increasing age during the rearing period. Comparing the treatment group with its related control group eNOS was expressed significantly only at d 21. Expression of iNOS mRNA also increased in both control and treatment groups with increasing age until d 28 and then decreased at d 35 and 42. Comparing the treatment group with its control group, iNOS mRNA level was significantly higher at 21 d of age in the cold-exposed chickens. It was concluded that, although cold exposure could significantly increase eNOS and iNOS gene expression, cold-induced pulmonary hypertension is not associated with significant variations of eNOS and iNOS expression in the lungs of broiler chickens.

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“…It has long been known to be the primary cause of death in birds reared at high altitude (Cueva et al, 1974). The pathology, which can develop quickly, results from hypoxia; consequently the birds become hypoxemic.…”

Section: Introductionmentioning

confidence: 99%

UK survey of broiler ascites and sudden death syndromes in 1993

Maxwell

Robertson²

1998

British Poultry Science

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1. The mean incidence of deaths from ascites in the UK in 1993 was 1.4% (0.7% in 1991 and 0.9% in 1992) and 0.8% from sudden death syndrome (SDS). In total, the economic loss to the UK Broiler Industry in 1993 as a result of these 2 conditions was 24 Pounds M. 2. Clear geographical differences emerged in the occurrence of ascites, with, not only the lowest incidences being observed in Northern Ireland, but also the peak of the mortality from ascites occurring much later in the rearing cycle than in other regions on the mainland. 3. In all regions the incidence of SDS was lower than that of ascites but the reason for this disparity remains to be established. 4. Some of the variables associated with the road transportation of day-old chicks from the hatchery to the farm appeared to influence the incidence of ascites. These included distance or time travelled, stocking density, internal lorry temperature and the length of time the lorry was heated before transport as well as the time the shed was heated before chick arrival. Temperature was also an important factor during growth (brooding and finishing). 5. Negative pressure-powered ventilation was preferred in most organisations but more ascites was seen with positive pressure ventilation. However, the lowest incidence of ascites occurred with natural ventilation. There was more ascites relative to shed orientation when the wind direction was from the west compared to the east. 6. This survey identifies the extent of the problem of broiler ascites in the UK and also highlights the importance of good management control of day-old chicks, not only following placement, but even before their arrival on the farm.

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High Altitude Induced Pulmonary Hypertension and Right Heart Failure in Broiler Chickens

Cited by 166 publications

References 11 publications

An ultrastructural study of an ascitic syndrome in young broilers reared at high altitude

An ultrastructural study of an ascitic syndrome in young broilers reared at high altitude

Evaluation of endothelial and inducible nitric oxide synthase mRNA expression in the lung of broiler chickens with developmental pulmonary hypertension due to cold stress

UK survey of broiler ascites and sudden death syndromes in 1993

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