High Altitude Pulmonary Edema in a Mining Worker With an Abnormal Rise in Pulmonary Artery Pressure in Response to Acute Hypoxia Without Prior History of High Altitude Pulmonary Edema

Akunov, Almaz; Sartmyrzaeva, Meerim; Maripov, Abdirashit; Uulu, Kubatbek Muratali; Mamazhakypov, Argen; Sydykov, Akylbek; Sarybaev, Akpay

doi:10.1016/j.wem.2017.04.003

Cited by 3 publications

(2 citation statements)

References 24 publications

(35 reference statements)

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“…In line with this notion, patients with idiopathic pulmonary arterial hypertension do not develop pulmonary edema. However, development of HAPE in persons with an exaggerated HPV can be provoked by the concurrent presence of several other HAPE risk factors, such as rapid ascent, the absolute altitude difference gained, pre-acclimatization, preceding viral upper respiratory tract infection, exposure to cold, and engagement in strenuous physical activity during the first days of acclimatization to high altitude [48,62,[89][90][91]. Earlier observations reported more frequent occurrence of HAPE in men than in women [62,92].…”

Section: Pulmonary Hypertension In High Altitude Pulmonary Edemamentioning

confidence: 99%

Pulmonary Hypertension in Acute and Chronic High Altitude Maladaptation Disorders

Sydykov

Mamazhakypov

Maripov

et al. 2021

IJERPH

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Alveolar hypoxia is the most prominent feature of high altitude environment with well-known consequences for the cardio-pulmonary system, including development of pulmonary hypertension. Pulmonary hypertension due to an exaggerated hypoxic pulmonary vasoconstriction contributes to high altitude pulmonary edema (HAPE), a life-threatening disorder, occurring at high altitudes in non-acclimatized healthy individuals. Despite a strong physiologic rationale for using vasodilators for prevention and treatment of HAPE, no systematic studies of their efficacy have been conducted to date. Calcium-channel blockers are currently recommended for drug prophylaxis in high-risk individuals with a clear history of recurrent HAPE based on the extensive clinical experience with nifedipine in HAPE prevention in susceptible individuals. Chronic exposure to hypoxia induces pulmonary vascular remodeling and development of pulmonary hypertension, which places an increased pressure load on the right ventricle leading to right heart failure. Further, pulmonary hypertension along with excessive erythrocytosis may complicate chronic mountain sickness, another high altitude maladaptation disorder. Importantly, other causes than hypoxia may potentially underlie and/or contribute to pulmonary hypertension at high altitude, such as chronic heart and lung diseases, thrombotic or embolic diseases. Extensive clinical experience with drugs in patients with pulmonary arterial hypertension suggests their potential for treatment of high altitude pulmonary hypertension. Small studies have demonstrated their efficacy in reducing pulmonary artery pressure in high altitude residents. However, no drugs have been approved to date for the therapy of chronic high altitude pulmonary hypertension. This work provides a literature review on the role of pulmonary hypertension in the pathogenesis of acute and chronic high altitude maladaptation disorders and summarizes current knowledge regarding potential treatment options.

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Section: Pulmonary Hypertension In High Altitude Pulmonary Edemamentioning

confidence: 99%

Pulmonary Hypertension in Acute and Chronic High Altitude Maladaptation Disorders

Sydykov

Mamazhakypov

Maripov

et al. 2021

IJERPH

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“…Among these factors, oxygen deficiency plays a vital role in the development of AMS (Gonggalanzi et al., 2017). AMS can progress to life‐threatening high‐altitude pulmonary edema (HAPE) (Akunov et al., 2017; Du, Zhao, Su, Liu, & Yang, 2018) or to high‐altitude cerebral edema (HACE) (Li, Zhang, & Zhang, 2018; West, 2015), which have a detrimental impact on an individual's health, thereby reducing the physical capability. As the modern community is increasingly undertaking activities in high plateau environments, AMS has become a public health problem.…”

Section: Introductionmentioning

confidence: 99%

HSPA1A gene polymorphism rs1008438 is associated with susceptibility to acute mountain sickness in Han Chinese individuals

Liu

Chen

et al. 2020

Molec Gen & Gen Med

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Background Acute mountain sickness (AMS) usually occurs among non‐acclimated individuals after rapid ascending to high‐altitude environments (generally ≥2,500 m). However, the precise molecular mechanism of AMS remains unclear. Our study aimed to investigate the relationship between several single nucleotide polymorphisms (SNPs) and AMS susceptibility. Methods In this work, sequencing data were obtained from 69 AMS patients and 95 matched acclimated Han Chinese individuals from southwest China. Five SNPs (rs1008438, rs150877473, rs1799983, rs2153364, and rs3025039) were systematically investigated in all the participants. Results In our study, we found that allele frequencies of “A” (AMS 69.57% vs. non‐AMS 54.74%) and “C” (AMS 30.43% vs. non‐AMS 45.26%) in the HSPA1A gene rs1008438 were significantly different between the AMS and non‐AMS groups ( p = .01). Genotypes “CC” and “CA” of the HSPA1A gene (rs1008438) were associated with lower risk of developing AMS than the genotype “AA.” Comparing the genotypes “CC + CA” and “AA,” we also observed that the “CC + CA” genotype of rs1008438 was associated with lower AMS risk. Conclusions In our case‐control study, there was a significant association between the rs1008348 polymorphism and AMS susceptibility, suggesting that this particular SNP might be a Han‐specific risk factor for AMS. We believe that this study establishes a foundation for further elucidation of the genetic mechanisms underlying AMS.

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Simulation Study on the Dynamic Ventilation Control of Single Head Roadway in High‐Altitude Mine Based on Thermal Comfort

Nie

Feng

Shudu

et al. 2019

Advances in Civil Engineering

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Dynamic ventilation control based on the concept of thermal comfort is proposed and applied to single head roadway in high-altitude gold mine in Qinghai. Hourly thermal comfort values are determined for typical working conditions, and a thermal comfort curve is generated. The values are adjusted based on the external environment and the changes in the miners’ thermal comfort. The Fluent software is used to simulate the temperature field and wind speed field of the tunnel roadway at three heights, and the results are used to fit the thermal comfort curve in the roadway. The results show that the thermal comfort is lowest at a roadway height of 1 m and a longitudinal length of 16 m because the wind speed is the highest and the temperature is lowest at these locations. When the dynamic ventilation control is used, the optimal thermal comfort levels can be determined for the locations in the single head roadway.

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High Altitude Pulmonary Edema in a Mining Worker With an Abnormal Rise in Pulmonary Artery Pressure in Response to Acute Hypoxia Without Prior History of High Altitude Pulmonary Edema

Cited by 3 publications

References 24 publications

Pulmonary Hypertension in Acute and Chronic High Altitude Maladaptation Disorders

Pulmonary Hypertension in Acute and Chronic High Altitude Maladaptation Disorders

HSPA1A gene polymorphism rs1008438 is associated with susceptibility to acute mountain sickness in Han Chinese individuals

Simulation Study on the Dynamic Ventilation Control of Single Head Roadway in High‐Altitude Mine Based on Thermal Comfort

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