2020
DOI: 10.1177/0271678x20942609
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High-altitude rodents have abundant collaterals that protect against tissue injury after cerebral, coronary and peripheral artery occlusion

Abstract: Collateral number/density varies widely in brain and other tissues among strains of Mus musculus mice due to differences in genetic background. Recent studies have shown that prolonged exposure to reduced atmospheric oxygen induces additional collaterals to form, suggesting that natural selection may favor increased collaterals in populations native to high-altitude. High-altitude guinea pigs ( Cavia) and deer mice ( Peromyscus) were compared with lowland species of Peromyscus, Mus and Rattus (9 species/strain… Show more

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Cited by 19 publications
(19 citation statements)
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References 86 publications
(212 reference statements)
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“… Steiner et al (2010) and Ben Ahmed et al (2015) stratified patients with obstructive sleep apnea based on their apnea-hypopnea index, and reported an increased number of coronary collateral vessels in patients with 10 or more events per hour compared to patients without obstructive sleep apnea ( Ben Ahmed et al, 2015 ; Steiner et al, 2010 ). Increased myocardial coronary collateralization of the heart in response to ischemia or hypoxia has also been demonstrated in mice ( Faber et al, 2021 ) and rats ( Banai et al, 1994 ). Increased skeletal muscle capillary proliferation and up-regulation of vascular endothelial growth factor has also been reported in patients with obstructive sleep apnea ( Wahlin-Larsson et al, 2009 ).…”
Section: Repetitive Intermittent Hypoxia and Beneficial Cardiovascular Outcomes In Patient Populationsmentioning
confidence: 94%
“… Steiner et al (2010) and Ben Ahmed et al (2015) stratified patients with obstructive sleep apnea based on their apnea-hypopnea index, and reported an increased number of coronary collateral vessels in patients with 10 or more events per hour compared to patients without obstructive sleep apnea ( Ben Ahmed et al, 2015 ; Steiner et al, 2010 ). Increased myocardial coronary collateralization of the heart in response to ischemia or hypoxia has also been demonstrated in mice ( Faber et al, 2021 ) and rats ( Banai et al, 1994 ). Increased skeletal muscle capillary proliferation and up-regulation of vascular endothelial growth factor has also been reported in patients with obstructive sleep apnea ( Wahlin-Larsson et al, 2009 ).…”
Section: Repetitive Intermittent Hypoxia and Beneficial Cardiovascular Outcomes In Patient Populationsmentioning
confidence: 94%
“…Perhaps a more physiological—non invasive—way to promote VEGF-Kdrl signaling is to reduce the ambient oxygen tension by moving from sea level to high altitude. As nicely demonstrated by the group of Jim Faber, high altitude rodents such as guinea pigs and deer mice featured a much higher number of collaterals than lowlander species, and were much better protected against cerebral ischemia [ 50 ]. The question then is how can lowlanders benefit from this vascular growth potential?…”
Section: Arteriogenesis In the Developing Vasculaturementioning
confidence: 99%
“…As an illustration of the importance of collaterals and the capacity to respond to hemodynamic modifications, it has been shown that genetic selection in rodents native to high elevations has resulted in the presence of abundant leptomeningeal arterial collaterals, to optimize oxygen delivery and to meet oxygen demand in conditions of oxygen limitation. These rodents display almost complete protection against stroke, much stronger than that observed in lowland rodents [ 29 ]. No clinical reports of a correlation between stroke severity, elevation, and collateral blood supply have been published.…”
Section: Preclinical Stroke Models and Collateral Supply Efficacymentioning
confidence: 99%