High ambulatory blood pressure values associated with non-alcoholic fatty liver in middle-aged adults

Vasunta, Riitta-Liisa; Kesäniemi, Y. Antero; Ylitalo, Antti; Ukkola, Olavi

doi:10.1097/hjh.0b013e3283576faf

Cited by 32 publications

(24 citation statements)

References 27 publications

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“…We found that adult measures of adiposity, triglycerides, insulin, systolic blood pressure, physical activity, and red meat consumption were on the pathway linking childhood SED with fatty liver. All these observed mediators have been previously associated with fatty liver . Adiposity and insulin resistance are considered key factors in the pathophysiology of fatty liver .…”

Section: Discussionmentioning

confidence: 95%

“…Adiposity and insulin resistance are considered key factors in the pathophysiology of fatty liver . Systolic blood pressure is also associated with fatty liver, but the mechanisms that explain the association that are independent of adiposity or insulin resistance remain unknown . In addition, physical inactivity and unhealthy dietary habits, especially high consumption of red meat, have been considered behavioral risk factors of fatty liver .…”

Section: Discussionmentioning

confidence: 99%

“…All these observed mediators have been previously associated with fatty liver. (3,4,6,(13)(14)(15)(16) Adiposity and insulin resistance are considered key factors in the pathophysiology of fatty liver. (6) Systolic blood pressure is also associated with fatty liver, but the mechanisms that explain the association that are independent of adiposity or insulin resistance remain unknown.…”

Section: Discussionmentioning

confidence: 99%

“…(6) Systolic blood pressure is also associated with fatty liver, but the mechanisms that explain the association that are independent of adiposity or insulin resistance remain unknown. (13)(14)(15)(16) In addition, physical inactivity and unhealthy dietary habits, especially high consumption of red meat, have been considered behavioral risk factors of fatty liver. (3,4) In this study, the highest proportions mediated of the total effect of childhood SED were observed for adulthood measures of high waist circumference (45%), BMI (40%), and systolic blood pressure (29%).…”

Section: Discussionmentioning

confidence: 99%

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Childhood Socioeconomic Disadvantage and Risk of Fatty Liver in Adulthood: The Cardiovascular Risk in Young Finns Study

et al. 2019

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Fatty liver is a preventable cause of liver failure, but early risk factors for adulthood fatty liver are poorly understood. We examined the association of childhood socioeconomic disadvantage with adulthood fatty liver and tested adulthood risk factors of fatty liver as possible mediators of this link. The study population comprised 2,042 participants aged 3‐18 years at baseline (1980) from the longitudinal Cardiovascular Risk in Young Finns Study. Follow‐up with repeated clinical examinations was 31 years. Childhood socioeconomic disadvantage was assessed using data from parents’ socioeconomic position and socioeconomic circumstances in participants’ residential neighborhoods, categorized as high versus low socioeconomic disadvantage. Fatty liver was determined by ultrasound during the last follow‐up (2011) at ages 34‐49 years. Childhood and adulthood risk factors, including metabolic biomarkers and lifestyle variables, were assessed in clinical examinations. A total of 18.9% of the participants had fatty liver in adulthood. High childhood socioeconomic disadvantage was associated with an increased risk of fatty liver (risk ratio [95% confidence interval], 1.42 [1.18‐1.70]; P = 0.0002). This association was robust to adjustment for age, sex, and childhood risk factors of fatty liver, including high body mass index, elevated insulin, and low birth weight (1.33 [1.09‐1.62]; P = 0.005). High childhood socioeconomic disadvantage was also associated with the development of risk factors of fatty liver in adulthood. Adulthood risk factors linking childhood socioeconomic disadvantage with fatty liver included waist circumference (proportion mediated of the total effect of childhood socioeconomic disadvantage, 45%), body mass index (40%), systolic blood pressure (29%), insulin (20%), physical activity (15%), triglycerides (14%), and red meat consumption (7%). Conclusion: Childhood socioeconomic disadvantage was associated with multiple risk factors of fatty liver and increased likelihood of fatty liver in adulthood.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Childhood Socioeconomic Disadvantage and Risk of Fatty Liver in Adulthood: The Cardiovascular Risk in Young Finns Study

et al. 2019

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“…Blood pressure (BP), including systolic blood pressure (SBP) and diastolic blood pressure (DBP), is an important risk factor for developing NAFLD [7][8][9][10], even in individuals without hypertension [10]. Mean arterial pressure (MAP), a steady component of BP, has wildly been used in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

Mean Arterial Pressure Is Related to Incident Nonalcoholic Fatty Liver Disease among the Nonobese Female with Normal Low-Density Lipoprotein Cholesterol Levels: A Large Cohort Study in China

Chen

Hong

et al. 2020

Gastroenterology Research and Practice

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Aim. We aimed to demonstrate the independent effect of mean arterial pressure (MAP) on incident nonalcoholic fatty liver disease (NAFLD) among the nonobese Chinese with normal low-density lipoprotein cholesterol (LDL-C) levels. Methods. 16,153 nonobese participants without NAFLD at baseline were enrolled and then assigned to four groups by quartiles of MAP (Q1-Q4). A subgroup analysis by gender was also conducted. Participants were diagnosed with NAFLD by ultrasonography. Results. During a mean follow-up of 2.80 years, the cumulative incidence of NAFLD was 14.37 and the incidence rate was 513.17 per 10,000 person-years. The cumulative incidence of NAFLD for the whole population or gender groups gradually increased with the quartiles of MAP (all P<0.001). In the Q4 of MAP, the cumulative incidence of NAFLD for the whole population, male, and female reached up to 6.22 (5.75-6.70), 6.70 (6.21-7.19), and 5.69 (5.24-6.14), respectively. After adjustment for potential confounders, as compared with Q1, the hazard ratio for NAFLD was 1.328 (1.072-1.647), 1.625 (1.276-2.069), and 1.697 (1.231-2.340) for Q2, Q3, and Q4, respectively. In subgroup analysis, the respective hazard ratio for NAFLD in Q2, Q3, and Q4 of MAP was 1.760 (1.276-2.429), 2.080 (1.433-3.019), and 2.377 (1.452-3.890), compared with female in the Q1 of MAP. But MAP was not associated with incident NAFLD in male. Besides, MAP had a larger area under the receiver-operating characteristic curves than SBP or DBP, with optimal cutoff point of 88 mmHg in male and 89 mmHg in female. Conclusions. MAP is an independent predictor for incident NAFLD among nonobese female with normal LDL levels.

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Decrease in major secondary bile acid, hyodeoxycholic acid, was the main alteration in hepatic bile acid compositions in a hypertensive nonalcoholic fatty liver disease model

Kodama

Kanno

Kishikawa

et al. 2019

J Hepato Biliary Pancreat

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Background Previous findings on hepatic bile acid compositions in nonalcoholic fatty liver disease (NAFLD) have been inconsistent and complicated. The aim of this study was to investigate the effects of steatosis on hepatic bile acid composition in a hypertensive NAFLD model without obesity and diabetes mellitus and compare hepatic bile acid composition between hypertensive rats with and without steatosis. Methods Two groups of hypertensive rats were studied: spontaneously hypertensive rats (SHR) fed with a normal diet (SHR‐N) or a choline‐deficient diet (SHR‐CD). Two groups of normotensive rats were studied: Wistar Kyoto rats (WKY) fed a normal diet (WKY‐N) or a choline‐deficient diet (WKY‐CD). Hepatic bile acid analysis was performed using liquid chromatography–electrospray ionization–tandem mass spectrometry. Results Regarding bile acid composition, the hyodeoxycholic acid (HDCA) species in the SHR‐CD group showed the largest change in bile acid composition, significantly decreasing to 21.9% of that found in the SHR‐N group. In the WKY‐CD group, no reduction of HDCA species was observed. Conclusions We demonstrated that the decrease in HDCA species was the main alteration in a hypertensive NAFLD model. It was suggested that the decrease in HDCA species in the SHR‐CD group was caused by dysbiosis.

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High ambulatory blood pressure values associated with non-alcoholic fatty liver in middle-aged adults

Abstract: Significantly higher ambulatory daytime and night-time SBP levels were seen in individuals with fatty liver. Nondipping does not seem to associate with liver fat. The coexistence of liver fat accumulation and high BP are likely to potentiate the risk for cardiovascular disease.

Cited by 32 publications

References 27 publications

Childhood Socioeconomic Disadvantage and Risk of Fatty Liver in Adulthood: The Cardiovascular Risk in Young Finns Study

Childhood Socioeconomic Disadvantage and Risk of Fatty Liver in Adulthood: The Cardiovascular Risk in Young Finns Study

Mean Arterial Pressure Is Related to Incident Nonalcoholic Fatty Liver Disease among the Nonobese Female with Normal Low-Density Lipoprotein Cholesterol Levels: A Large Cohort Study in China

Decrease in major secondary bile acid, hyodeoxycholic acid, was the main alteration in hepatic bile acid compositions in a hypertensive nonalcoholic fatty liver disease model

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