High amounts of chlorinated paraffins in oil-based vitamin E dietary supplements on the German market

Sprengel, Jannik; Wieselmann, Sina; Kröpfl, Alexander; Vetter, Walter

doi:10.1016/j.envint.2019.04.065

Cited by 34 publications

(34 citation statements)

References 34 publications

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“…These data could not be included on time in the EFSA Data warehouse for the current risk assessment, but the data were published by Sprengel et al. () and the outcome is described in Sections 3.2.2 and 3.3.2 .…”

Section: Data and Methodologiesmentioning

confidence: 99%

“…In addition, data on the occurrence of CPs in oil-based dietary supplements was submitted to EFSA. These data could not be included on time in the EFSA Data warehouse for the current risk assessment, but the data were published by Sprengel et al (2019) and the outcome is described in Sections 3.2. 2 and 3.3.2. No data were submitted on LCCPs for food, and there were not data submitted on any CPs for feed materials.…”

Section: Appraisal Of Evidencementioning

confidence: 99%

“…The sum of SCCPs and MCCPs was higher than the sum of PCBs and that of HBCDDs in most of the samples. Sprengel et al (2019) reported levels of MCCPs in oil-based dietary supplements. The mean (min, max) MCCP concentrations were higher than that found for SCCPs, and were 15,200 (< LOQ,151,000) lg/kg fat.…”

Section: Mccpsmentioning

confidence: 99%

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Risk assessment of chlorinated paraffins in feed and food

Schrenk¹,

Bignami²,

Bodin³

et al. 2020

EFS2

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The European Commission asked EFSA for a scientific opinion on the risks for animal and human health related to the presence of chlorinated paraffins in feed and food. The data for experimental animals were reviewed and the CONTAM Panel identified the liver, kidney and thyroid as the target organs for the SCCP and MCCP mixtures tested in repeated dose toxicity studies. Decreased pup survival and subcutaneous haematoma/haemorrhage were also identified as critical effects for an MCCP mixture. For the LCCP mixtures tested, the liver was identified as the target organ. The Panel selected as reference points a BMDL10 of 2.3 mg/kg bw per day for increased incidence of nephritis in male rats, and of 36 mg/kg bw per day for increased relative kidney weights in male and female rats for SCCPs and MCCPs, respectively. For LCCPs, a reference point relevant for humans could not be identified. Due to the limitations in the toxicokinetic and toxicological database, the Panel concluded that derivation of a health‐based guidance value was not appropriate. Only limited data on the occurrence of SCCPs and MCCPs in some fish species were submitted to EFSA. No data were submitted for LCCPs. Thus, a robust exposure assessment and consequently a complete risk characterisation could not be performed. A preliminary risk characterisation based only on the consumption of fish was performed, and the calculated margins of exposure suggested no health concern for this limited scenario. The Panel noted that dietary exposure will be higher due to the contribution of CPs from other foods. The Panel was not able to identify reference points for farm animals, horses and companion animals. No occurrence data for feed were submitted to EFSA. Therefore, no risk characterisation could be performed for any of these animal species.

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Section: Data and Methodologiesmentioning

confidence: 99%

Section: Appraisal Of Evidencementioning

confidence: 99%

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Risk assessment of chlorinated paraffins in feed and food

Schrenk¹,

Bignami²,

Bodin³

et al. 2020

EFS2

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“…This indicated that CP are among the dominant substances in this matrix. In addition, vitamin E dietary supplements, based on palm oil, can be a source of MCCP (Sprengel et al 2019). A mean dietary uptake of up to 38 µg/ person per day (range of 12-112 µg/person) is calculated by the authors, if the dietary supplements are used according to the recommendations as printed on the package.…”

mentioning

confidence: 99%

MCCP: are medium-chain chlorinated paraffins of concern for humans?

et al. 2020

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“…The outcome of the study by Sprengel et al (2019) is reported in Section 3.2.2 and Section 3.3.2 of the Opinion. In addition, the authors submitted these data to EFSA, although these data could not be included on time in the EFSA Data warehouse for the current risk assessment and the estimates of exposure made by EFSA (see Section 2.2 of the Opinion).…”

mentioning

confidence: 99%

Outcome of a public consultation on the draft risk assessment of chlorinated paraffins in feed and food

Rose¹

2020

EFSA Supporting Publications

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The European Food Safety Authority (EFSA) carried out a public consultation to receive input from interested parties on the draft scientific opinion on the risk assessment of chlorinated paraffins in feed and food. This draft scientific opinion was prepared by the EFSA Panel on Contaminants in the Food Chain (CONTAM Panel), supported by the Working Group on Chlorinated Paraffins in food and feed.The draft opinion was endorsed by the CONTAM Panel for public consultation by written procedure on 31 July 2019. The written public consultation was open from 6 August until17 September 2019. EFSA received comments from 11 different interested parties. EFSA and its CONTAM Panel wish to thank all stakeholders for their contributions. The present report contains the comments received and explains the way they have been considered for finalisation of the opinion. The opinion was adopted at the CONTAM Plenary meeting on 17 December 2019 and published in the EFSA Journal.

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High amounts of chlorinated paraffins in oil-based vitamin E dietary supplements on the German market

Cited by 34 publications

References 34 publications

Risk assessment of chlorinated paraffins in feed and food

Risk assessment of chlorinated paraffins in feed and food

MCCP: are medium-chain chlorinated paraffins of concern for humans?

Outcome of a public consultation on the draft risk assessment of chlorinated paraffins in feed and food

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