1987
DOI: 10.1111/j.1476-5381.1987.tb11207.x
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High and concentration‐proportional accumulation of [3H]‐nitrendipine by intact cardiac tissue

Abstract: 1 The binding of [3H]-nitrendipine to intact, electrically driven isolated left atria of guinea-pigs was investigated over the concentration range 10-10M to 3 x 10-lM. 2 A high affinity binding site saturable in the nM range as found in ventricular homogenates could not be detected. Instead the accumulation ofnitrendipine in intact atria was found to be proportional to the concentration from 10-"°M to 106m; beyond 10-6 M the binding started to become saturated.3 Nitrendipine was highly accumulated in atrial ti… Show more

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Cited by 14 publications
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